Patents by Inventor Bipulendu JENA

Bipulendu JENA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T-cell receptor (TCR)-binding antibodies and uses thereof
    Patent number: 11548945
    Abstract: Antibodies and antigen binding fragments thereof are provided that bind to T-cell receptors (e.g., TCR?), essentially independent of T-cell epitope specificity. Methods for manipulation of T-cells and methods of treatment using such antibodies are likewise provided.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: January 10, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Laurence J. N. Cooper, Bipulendu Jena
  • GENE MODIFIED IMMUNE EFFECTOR CELLS AND ENGINEERED CELLS FOR EXPANSION OF IMMUNE EFFECTOR CELLS
    Publication number: 20220072041
    Abstract: Chimeric antigen receptor (CAR) polypeptides (and immune effector cells expressing the CARs) are provided comprising modified hinge domain sequences. Also provided are engineered antigen presenting cells (APCs) that express transgenes encoding target antigen and human leukocyte antigen (HLA). In further aspect, immune effector cells are provided that have been selected for elevated mitochondrial spare respiratory capacity.
    Type: Application
    Filed: July 9, 2021
    Publication date: March 10, 2022
    Inventors: Laurence J.N. COOPER, Harjeet SINGH, Helen HULS, Simon OLIVARES, Bipulendu JENA, Krina PATEL
  • T-CELL RECEPTOR (TCR)-BINDING ANTIBODIES AND USES THEREOF
    Publication number: 20200299386
    Abstract: Antibodies and antigen binding fragments thereof are provided that bind to T-cell receptors (e.g., TCR?), essentially independent of T-cell epitope specificity. Methods for manipulation of T-cells and methods of treatment using such antibodies are likewise provided.
    Type: Application
    Filed: March 30, 2020
    Publication date: September 24, 2020
    Inventors: Laurence J.N. COOPER, Bipulendu JENA
  • CHIMERIC ANTIGEN RECEPTORS (CAR) TO SELECTIVELY TARGET PROTEIN COMPLEXES
    Publication number: 20200247867
    Abstract: Chimeric antigen receptor (CAR) constructs are provided that are able to selectively bind to specific protein complexes, such as HER1/HER3 heterodimer receptors. CAR T-cells comprising these constructs can be used to safely and efficiently target cancer cells expressing specific protein complexes.
    Type: Application
    Filed: January 16, 2020
    Publication date: August 6, 2020
    Inventors: Laurence J.N. COOPER, Bipulendu JENA
  • T-cell receptor (TCR)-binding antibodies and uses thereof
    Patent number: 10633445
    Abstract: Antibodies and antigen binding fragments thereof are provided that bind to T-cell receptors (e.g., TCR?), essentially independent of T-cell epitope specificity. Methods for manipulation of T-cells and methods of treatment using such antibodies are likewise provided.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: April 28, 2020
    Assignee: BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Laurence J. N. Cooper, Bipulendu Jena
  • Chimeric antigen receptors (CAR) to selectively target protein complexes
    Patent number: 10570186
    Abstract: Chimeric antigen receptor (CAR) constructs are provided that are able to selectively bind to specific protein complexes, such as HER 1/HER3 heterodimer receptors. CAR T-cells comprising these constructs can be used to safely and efficiently target cancer cells expressing specific protein complexes.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: February 25, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Laurence J. N. Cooper, Bipulendu Jena
  • T-CELL RECEPTOR (TCR)-BINDING ANTIBODIES AND USES THEREOF
    Publication number: 20180362648
    Abstract: Antibodies and antigen binding fragments thereof are provided that bind to T-cell receptors (e.g., TCR?), essentially independent of T-cell epitope specificity. Methods for manipulation of T-cells and methods of treatment using such antibodies are likewise provided.
    Type: Application
    Filed: September 15, 2016
    Publication date: December 20, 2018
    Inventors: Laurence J.N. COOPER, Bipulendu JENA
  • ANTI-CD19 scFv (FMC63) POLYPEPTIDE AND USES THEREOF
    Publication number: 20180265595
    Abstract: Provided are monoclonal antibodies that detect CD19 CAR-modified immune cells and CAR-modified immune cells irrespective of the tumor associated antigen they target. Methods of using these functional monoclonal antibodies include, but are not limited to, detection, quantification, activation, and selective propagation of CAR-modified immune cells.
    Type: Application
    Filed: March 5, 2018
    Publication date: September 20, 2018
    Inventors: Laurence JN COOPER, Bipulendu JENA, Sourindra MAITI, Harjeet SINGH, David RUSHWORTH
  • ANTI-CD19 scFv (FMC63) POLYPEPTIDE
    Publication number: 20170342164
    Abstract: Provided are monoclonal antibodies that detect CD19 CAR-modified immune cells and CAR-modified immune cells irrespective of the tumor associated antigen they target. Methods of using these functional monoclonal antibodies include, but are not limited to, detection, quantification, activation, and selective propagation of CAR-modified immune cells.
    Type: Application
    Filed: June 8, 2017
    Publication date: November 30, 2017
    Inventors: Laurence JN COOPER, Bipulendu JENA, Sourindra MAITI
  • GENE MODIFIED IMMUNE EFFECTOR CELLS AND ENGINEERED CELLS FOR EXPANSION OF IMMUNE EFFECTOR CELLS
    Publication number: 20170333480
    Abstract: Chimeric antigen receptor (CAR) polypeptides (and immune effector cells expressing the CARs) are provided comprising modified hinge domain sequences. Also provided are engineered antigen presenting cells (APCs) that express transgenes encoding target antigen and human leukocyte antigen (HLA). In further aspect, immune effector cells are provided that have been selected for elevated mitochondrial spare respiratory capacity.
    Type: Application
    Filed: November 5, 2015
    Publication date: November 23, 2017
    Inventors: Laurence J.N. COOPER, Harjeet SINGH, Helen HULS, Simon OLIVARES, Bipulendu JENA, Krina PATEL
  • CHIMERIC ANTIGEN RECEPTORS (CAR) TO SELECTIVELY TARGET PROTEIN COMPLEXES
    Publication number: 20170334968
    Abstract: Chimeric antigen receptor (CAR) constructs are provided that are able to selectively bind to specific protein complexes, such as HER 1/HER3 heterodimer receptors. CAR T-cells comprising these constructs can be used to safely and efficiently target cancer cells expressing specific protein complexes.
    Type: Application
    Filed: November 4, 2015
    Publication date: November 23, 2017
    Inventors: Laurence J.N. COOPER, Bipulendu JENA
  • Anti-CD19 scFv (FMC63) polypeptide
    Patent number: 9701758
    Abstract: Provided are monoclonal antibodies that detect CD 19 CAR-modified immune cells and CAR-modified immune cells irrespective of the tumor associated antigen they target. Methods of using these functional monoclonal antibodies include, but are not limited to, detection, quantification, activation, and selective propagation of CAR-modified immune cells.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: July 11, 2017
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Laurence J N Cooper, Bipulendu Jena, Sourindra Maiti
  • CHIMERIC ANTIGEN RECEPTOR-TARGETING MONOCLONAL ANTIBODIES
    Publication number: 20160096902
    Abstract: Provided are monoclonal antibodies that detect CD 19 CAR-modified immune cells and CAR-modified immune cells irrespective of the tumor associated antigen they target. Methods of using these functional monoclonal antibodies include, but are not limited to, detection, quantification, activation, and selective propagation of CAR-modified immune cells.
    Type: Application
    Filed: May 23, 2014
    Publication date: April 7, 2016
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Laurence JN COOPER, Bipulendu JENA, Harjeet SINGH, David RUSHWORTH