Patents by Inventor Biqi Wu

Biqi Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7781591
    Abstract: The present teachings provide compounds of formula I and their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: August 24, 2010
    Assignee: Wyeth LLC
    Inventors: Derek Cecil Cole, Diane Harris Boschelli, Yanong Daniel Wang, Magda Asselin, Diane Marie Joseph-McCarthy, Amarnauth Shastrie Prashad, Allan Wissner, Russell Dushin, Biqi Wu, Lawrence Nathan Tumey, Chuan S. Niu, Joan Chen
  • Patent number: 7767671
    Abstract: This invention provides a compound of Formula 1 where Ar, X, R1, R2, R3, and R4 are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition of diseases associated with the Ras/Raf/MEK signaling cascade in a mammal, such as neoplasms, strokes, osteoporosis, cancer, rheumatoid arthritis, inflammatory disease, polycystic kidney disease, and colonic polyps, and methods of making the compounds of formula 1 and intermediates.
    Type: Grant
    Filed: September 23, 2008
    Date of Patent: August 3, 2010
    Assignee: Wyeth
    Inventors: Dan Maarten Berger, Dennis William Powell, Biqi Wu
  • Publication number: 20090062281
    Abstract: This invention provides a compound of Formula 1 where Ar, X, R1, R2, R3, and R4 are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition of diseases associated with the Ras/Raf/MEK signaling cascade in a mammal, such as neoplasms, strokes, osteoporosis, cancer, rheumatoid arthritis, inflammatory disease, polycystic kidney disease, and colonic polyps, and methods of making the compounds of formula 1 and intermediates.
    Type: Application
    Filed: September 23, 2008
    Publication date: March 5, 2009
    Applicant: Wyeth
    Inventors: Dan Maarten Berger, Dennis William Powell, Biqi Wu
  • Patent number: 7479561
    Abstract: This invention relates to compounds having the structure of Formula I wherein R1, R2, R3, and R4 are described herein.
    Type: Grant
    Filed: August 11, 2005
    Date of Patent: January 20, 2009
    Assignee: Wyeth
    Inventors: Diane Harris Boschelli, Jay Thomas Afragola, Asaf Alimardanov, Biqi Wu
  • Patent number: 7449460
    Abstract: This invention provides a compound of Formula 1 where Ar, X, R1, R2, R3, and R4 are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition of diseases associated with the Ras/Raf/MEK signaling cascade in a mammal, such as neoplasms, strokes, osteoporosis, cancer, rheumatoid arthritis, inflammatory disease, polycystic kidney disease, and colonic polyps, and methods of making the compounds of formula 1 and intermediates.
    Type: Grant
    Filed: February 16, 2005
    Date of Patent: November 11, 2008
    Assignee: Wyeth
    Inventors: Dan Maarten Berger, Dennis William Powell, Biqi Wu
  • Publication number: 20080076926
    Abstract: A process for the preparation of 4-hydroxythieno[2,3-b]pyridine-5-carbonitriles, which can be useful for the preparation of protein kinase inhibitors, is provided.
    Type: Application
    Filed: September 25, 2007
    Publication date: March 27, 2008
    Inventors: Diane Boschelli, Lawrence Tumey, Biqi Wu
  • Publication number: 20080070913
    Abstract: This invention provides compounds of Formula (1a)-(1f), II wherein: X, m, n, q, R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Q, Z, Z?, Z??, Z? and J are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, myocardial infarction, neuropathic pain, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.
    Type: Application
    Filed: September 24, 2007
    Publication date: March 20, 2008
    Inventors: Diane Boschelli, Nan Zhang, Ana Barrios Sosa, Haris Durutlic, Biqi Wu
  • Publication number: 20070287708
    Abstract: The present teachings provide compounds of formula I and their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.
    Type: Application
    Filed: June 13, 2007
    Publication date: December 13, 2007
    Inventors: Derek Cole, Diane Boschelli, Yanong Wang, Magda Asselin, Diane Joseph-McCarthy, Amarnauth Prashad, Allan Wissner, Russell Dushin, Biqi Wu, Lawrence Tumey, Chuan Niu, Joan Chen
  • Patent number: 7276519
    Abstract: This invention provides compounds of Formula (1a)–(1f), II wherein: X, m, n, q, R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Q, Z, Z?, Z??, Z? and J are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, myocardial infarction, neuropathic pain, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: October 2, 2007
    Assignee: Wyeth
    Inventors: Diane Harris Boschelli, Nan Zhang, Ana Carolina Barrios Sosa, Haris Durutlic, Biqi Wu
  • Publication number: 20070082880
    Abstract: Disclosed are compounds of Formula I: wherein R1, R2, R3, R4, and X, are defined hereinbefore in the specification, which can be useful in the treatment of autoimmune and inflammatory diseases, and processes for producing said compounds.
    Type: Application
    Filed: September 27, 2006
    Publication date: April 12, 2007
    Inventors: Diane Boschelli, Derek Cole, Magda Asselin, Ana Barrios Sosa, Biqi Wu, Lawrence Tumey
  • Publication number: 20060247217
    Abstract: This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.
    Type: Application
    Filed: June 29, 2006
    Publication date: November 2, 2006
    Inventors: Dan Berger, Minu Dutia, Frenel DeMorin, Diane Boschelli, Dennis Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Patent number: 7105531
    Abstract: This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: September 12, 2006
    Assignee: WYETH
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Publication number: 20060063784
    Abstract: This invention relates to novel methods of use of certain pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. This invention also relates to novel methods of using these compounds as anti-proliferative agents in mammals, including humans.
    Type: Application
    Filed: September 9, 2005
    Publication date: March 23, 2006
    Inventors: Yanong Wang, Ariamala Gopalsamy, Erick Honores, Lee Jennings, Steven Johnson, Dennis Powell, Fuk-Wah Sum, Hwei-Ru Tsou, Biqi Wu, Nan Zhang
  • Publication number: 20060035930
    Abstract: This invention relates to compounds having the structure of Formula I wherein R1, R2, R3, and R4 are described herein.
    Type: Application
    Filed: August 11, 2005
    Publication date: February 16, 2006
    Applicant: Wyeth
    Inventors: Diane Boschelli, Jay Afragola, Asaf Alimardanov, Biqi Wu
  • Patent number: 6987116
    Abstract: This invention provides compounds of Formula (1a)-(1f) wherein: X, R1, and R2 are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: January 17, 2006
    Assignee: Wyeth
    Inventors: Diane Harris Boschelli, Nan Zhang, Ana Carolina Barrios Sosa, Haris Durutlic, Biqi Wu
  • Publication number: 20050187247
    Abstract: This invention provides a compound of Formula 1 where Ar, X, R1, R2, R3, and R4 are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition of diseases associated with the Ras/Raf/MEK signaling cascade in a mammal, such as neoplasms, strokes, osteoporosis, cancer, rheumatoid arthritis, inflammatory disease, polycystic kidney disease, and colonic polyps, and methods of making the compounds of formula 1 and intermediates.
    Type: Application
    Filed: February 16, 2005
    Publication date: August 25, 2005
    Applicant: Wyeth
    Inventors: Dan Berger, Dennis Powell, Biqi Wu
  • Publication number: 20040242883
    Abstract: This invention provides compounds of Formula (1a)-(1f), II 1
    Type: Application
    Filed: May 14, 2004
    Publication date: December 2, 2004
    Applicant: Wyeth
    Inventors: Diane Harris Boschelli, Nan Zhang, Ana Carolina Barrios Sosa, Haris Durutlic, Biqi Wu
  • Publication number: 20040176602
    Abstract: This invention provides compounds of Formula (I), having the structure 1
    Type: Application
    Filed: January 9, 2004
    Publication date: September 9, 2004
    Applicant: Wyeth
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils DeMorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Publication number: 20040138251
    Abstract: This invention provides compounds of Formula (Ia)-(If) 1
    Type: Application
    Filed: November 21, 2003
    Publication date: July 15, 2004
    Applicant: Wyeth
    Inventors: Diane Harris Boschelli, Nan Zhang, Ana Carolina Barrios Sosa, Haris Durutlic, Biqi Wu
  • Publication number: 20040110762
    Abstract: This invention provides compounds of formula 1, having the structure 1
    Type: Application
    Filed: July 10, 2003
    Publication date: June 10, 2004
    Applicant: WYETH
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu