Patents by Inventor Birgit GRAF

Birgit GRAF has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Click-modified mRNA
    Patent number: 12257267
    Abstract: The present invention relates to alkyne- and/or azide-modified mRNA, processes for producing such modified mRNA, cells which are transfected to include the modified mRNA, pharmaceutical compositions containing the modified mRNA or cells including the modified mRNA, and to uses of such mRNA, cells or pharmaceutical compositions in mRNA based therapeutic and/or prophylactic applications.
    Type: Grant
    Filed: October 12, 2022
    Date of Patent: March 25, 2025
    Assignee: BASECLICK GMBH
    Inventors: Thomas Frischmuth, Sascha Serdjukow, Birgit Graf, Stefano Croce
  • CLICK-MODIFIED MRNA
    Publication number: 20230226094
    Abstract: The present invention relates to alkyne- and/or azide-modified mRNA, processes for producing such modified mRNA, cells which are transfected to include the modified mRNA, pharmaceutical compositions containing the modified mRNA or cells including the modified mRNA, and to uses of such mRNA, cells or pharmaceutical compositions in mRNA based therapeutic and/or prophylactic applications.
    Type: Application
    Filed: October 12, 2022
    Publication date: July 20, 2023
    Inventors: Thomas FRISCHMUTH, Sascha SERDJUKOW, Birgit GRAF, Stefano CROCE
  • METHOD OF AMPLIFYING MRNAS AND FOR PREPARING FULL LENGTH MRNA LIBRARIES
    Publication number: 20220333184
    Abstract: An inventive method for amplifying at least one RNA which is contained in a sample includes reverse transcribing the at least one RNA using a first primer, adding a dideoxy nucleotide which is modified in the 3?-position with a first partner of a pair of azide and alkyne molecules by action of a template independent polymerase to attach a single 3?-azide- or 3?-alkyne-modified dideoxy nucleotide at the 3?-end of the obtained cDNA, adding an adapter molecule which comprises a polynucleotide sequence and at its 5?-end a second partner of such pair of azide and alkyne molecules and ligating the adapter to the 3?-modified cDNA under formation of a triazole linkage, adding a second primer which is complementary to at least a part of the adapter molecule and which contains at its 3?-end a nucleotide which is complementary to the dideoxy nucleotide at the 3?-end of the cDNA to effect hybridization and binding of the second primer overlapping the triazole linkage, adding a third primer and amplifying the full length
    Type: Application
    Filed: December 21, 2020
    Publication date: October 20, 2022
    Inventors: Thomas FRISCHMUTH, Sascha SERDJUKOW, Jessica SOBOTTA, Birgit GRAF
  • CLICK-MODIFIED MRNA
    Publication number: 20210069232
    Abstract: The present invention relates to alkyne- and/or azide-modified mRNA, processes for producing such modified mRNA, cells which are transfected to include the modified mRNA, pharmaceutical compositions containing the modified mRNA or cells including the modified mRNA, and to uses of such mRNA, cells or pharmaceutical compositions in mRNA based therapeutic and/or prophylactic applications.
    Type: Application
    Filed: December 18, 2018
    Publication date: March 11, 2021
    Inventors: Thomas FRISCHMUTH, Sascha SERDJUKOW, Birgit GRAF, Stefano CROCE