Patents by Inventor Birgit Keil

Birgit Keil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salts
    Patent number: 9926305
    Abstract: Salts of 1-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1R)-4-(trifluoromethyl) -2,3-dihydro-1H-inden-1-yl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid of the formula (I), in particular amino acid salts such as the lysine salt and alkali metal salts such as the sodium salt and the potassium salt, processes for their preparation, medicaments comprising them and their use for controlling diseases.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: March 27, 2018
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Britta Olenik, Birgit Keil, Martin-Holger Hinz, Chantal Fürstner, Mario Jeske, Jens Ackerstaff
  • METHOD FOR PRODUCING (4S)-4-[4-CYANO-2-(METHYLSULFONYL)PHENYL]-3,6-DIMETHYL-2-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,3,4-TETRAHYDRO PYRIMIDINE-5-CARBONITRILE
    Publication number: 20180072685
    Abstract: The present invention concerns a new and improved method for preparation of (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluormethyl)phenyl]-1,2,3,4-tetrahydro pyrimidine-5-carbonitrile of formula (I), as well as the preparation and use of the crystal form (A) of (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluormethyl)phenyl]-1,2,3,4-tetrahydro pyrimidine-5-carbonitrile of formula (I).
    Type: Application
    Filed: March 15, 2016
    Publication date: March 15, 2018
    Applicant: pH Pharma, Ltd.
    Inventors: Heiko Schirmer, Philipp Rubenbauer, Birgit Keil, Britta Olenik
  • FORMS OF METHYL {4,6-DIAMINO-2-[1 (2-FLUOROBENZYL)-1H-PYRAZOLO[3-4-B]PYRIDINO-3-YL]PYRIMIDINO-5-YL}METHYL CARBAMATE
    Publication number: 20170334910
    Abstract: This present invention relates to forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methylcarbamate comprising its Modification I, Modification II, mono-DMSO solvate, sesqui-DMSO solvate and ¼-ethyl acetate solvate.
    Type: Application
    Filed: August 9, 2017
    Publication date: November 23, 2017
    Applicant: Adverio Pharma GmbH
    Inventors: Birgit KEIL, Franz-Josef MAIS, Winfried JOENTGEN, Alfons GRUNENBERG
  • Sodium and calcium salts of dihydroquinazoline derivative and use thereof as antiviral agents
    Patent number: 9637459
    Abstract: The invention relates to sodium and calcium salts of {8-fluoro-2-[4-(3-methoxyphenyl)piperazine-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazoline-4-yl}acetic acid and solvates thereof, to the use thereof in a method of treatment and/or prophylaxis of virus infections and to the use thereof for producing drugs for use in methods of treatment and/or prophylaxis of diseases, more particularly the use thereof as antiviral agents, more particularly against cytomegaloviruses.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: May 2, 2017
    Assignee: AICURIS GMBH & CO KG.
    Inventors: Alfons Grunenberg, Mathias Berwe, Birgit Keil, Edwin Aret, Kerstin Paulus, Wilfried Schwab
  • NOVEL SALTS
    Publication number: 20160289220
    Abstract: Salts of 1-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid of the formula (I), in particular amino acid salts such as the lysine salt and alkali metal salts such as the sodium salt and the potassium salt, processes for their preparation, medicaments comprising them and their use for controlling diseases.
    Type: Application
    Filed: November 5, 2014
    Publication date: October 6, 2016
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Britta OLENIK, Birgit KEIL, Martin-Holger HINZ, Chantal FURSTNER, Mario JESKE, Jens ACKERSTAFF
  • N-[5-(Aminosulfony1)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
    Patent number: 9340535
    Abstract: The present invention relates to an improved and shortened synthesis of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide and the mesylate monohydrate salt thereof by using boronic acid derivatives or borolane reagents while avoiding toxic organic tin compounds and to the mesylate monohydrate salt of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: May 17, 2016
    Assignee: AICURIS GMBH & CO. KG
    Inventors: Wilfried Schwab, Alexander Birkmann, Kurt Vogtli, Dieter Haag, Andreas Lender, Alfons Grunenberg, Birgit Keil, Joachim Rehse
  • FORMS OF METHYL METHYL CARBAMATE
    Publication number: 20150376184
    Abstract: This present invention relates to forms of methyl {4.6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3.4-b]pyridino-3-yl]pyrimidino-5-yl}methylcarbamate comprising its Modification I. Modification II. mono-DMSO solvate. sesqui-DMSO solvate and ¼-ethyl acetate solvate.
    Type: Application
    Filed: February 18, 2014
    Publication date: December 31, 2015
    Applicant: Adverio Pharma GmbH
    Inventors: Birgit KEIL, Franz-Josef MAIS, Winfried JOENTGEN, Alfons GRUNENBERG
  • SODIUM AND CALCIUM SALTS OF DIHYDROQUINAZOLINE DERIVATIVE AND USE THEREOF AS ANTIVIRAL AGENTS
    Publication number: 20150038514
    Abstract: The invention relates to sodium and calcium salts of {8-fluoro-2-[4-(3-methoxyphenyl)piperazine-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazoline-4-yl}acetic acid and solvates thereof, to the use thereof in a method of treatment and/or prophylaxis of virus infections and to the use thereof for producing drugs for use in methods of treatment and/or prophylaxis of diseases, more particularly the use thereof as antiviral agents, more particularly against cytomegaloviruses.
    Type: Application
    Filed: February 28, 2013
    Publication date: February 5, 2015
    Inventors: Alfons Grunenberg, Mathias Berwe, Birgit Keil, Edwin Aret, Kerstin Paulus, Wilfried Schwab
  • 4-[4-(AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE MONOHYDRATE
    Publication number: 20140315958
    Abstract: The present invention relates to 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate, to processes for its preparation, to pharmaceutical compositions comprising it and to its use in the control of disorders.
    Type: Application
    Filed: May 14, 2014
    Publication date: October 23, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Alfons GRUENBERG, Juregen STIEHL, Katharina TENBIEF, Birgit KEIL
  • N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
    Publication number: 20140221433
    Abstract: The present invention relates to an improved and shortened synthesis of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide and the mesylate monohydrate salt thereof by using boronic acid derivatives or borolane reagents while avoiding toxic organic tin compounds and to the mesylate monohydrate salt of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions.
    Type: Application
    Filed: September 26, 2012
    Publication date: August 7, 2014
    Applicant: AICURIS GMBH & CO. KG
    Inventors: Wilfried Schwab, Alexander Birkmann, Kurt Vogtli, Dieter Haag, Andreas Lender, Alfons Grunenberg, Birgit Keil, Joachim Reshe
  • Co-crystal compound of rivaroxaban and malonic acid
    Patent number: 8466280
    Abstract: The present invention relates to a novel cocrystal compound of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide (rivaroxaban) and malonic acid, to processes for its preparation, to medicaments comprising this compound and to their use for controlling diseases.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: June 18, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Alfons Grunenberg, Karsten Fähnrich, Olaf Queckenberg, Christiane Reute, Birgit Keil, Karen Sue Gushurst, Ezra John Still
  • NOVEL SOLVATES OF METHYLCARBAMATE
    Publication number: 20120316183
    Abstract: The invention relates to novel solvates of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate, in particular the semi-ethanol solvate of the formula (Ia), to processes for their preparation, to medicaments comprising them and to their use for controlling diseases
    Type: Application
    Filed: December 13, 2010
    Publication date: December 13, 2012
    Applicant: Bayer Intellecutal Property GmbH
    Inventors: Alfons Grunenberg, Franz-Josef Mais, Winfried Joentgen, Birgit Keil
  • Polymorphous form of 5-chloro-N-({(5S)-2-oxo-3[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide
    Patent number: 8188270
    Abstract: The present invention relates to a novel polymorphic form and the amorphous form of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophene-carboxamide, processes for their preparation, medicaments comprising these forms, and their use in the control of diseases.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: May 29, 2012
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Alfons Grunenberg, Jana Lenz, Gerhard Arnold Braun, Birgit Keil, Christian R. Thomas
  • MODIFICATION I OF 4-(PHENYL)ETHYL]-AMINO}METHYL)BENZOIC ACID
    Publication number: 20120010292
    Abstract: The invention relates to novel forms of 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenyl-ethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, in particular to the modification I, to processes for their preparation, to medicaments comprising them and to their use for fighting diseases.
    Type: Application
    Filed: December 4, 2009
    Publication date: January 12, 2012
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Alfons Grunenberg, Franz-Josef Mais, Katharina Tenbieg, Birgit Keil
  • Monohydrate of 4-(phenyl)ethyl]-amino}methyl)benzoic acid
    Publication number: 20110288174
    Abstract: The invention relates to novel forms of 4-({(4-carboxybutyl) [2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, in particular to the monohydrate in form A, to processes for their preparation, to medicaments comprising them and to their use for fighting diseases.
    Type: Application
    Filed: December 8, 2009
    Publication date: November 24, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Alfons Grunenberg, Franz-Josef Mais, Katharina Tenbieg, Birgit Keil
  • NOVEL POLYMORPHIC FORMS OF METHYL CARBAMATE
    Publication number: 20110183999
    Abstract: The invention relates to novel forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate of the formula (I), in particular to the modification I, to processes for their preparation, to medicaments comprising them and to their use for fighting diseases.
    Type: Application
    Filed: November 29, 2010
    Publication date: July 28, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Alfons GRUNENBERG, Franz-Josef MAIS, Winfried JOENTGEN, Birgit KEIL
  • CO-CRYSTAL COMPOUND OF RIVAROXABAN AND MALONIC ACID
    Publication number: 20110152266
    Abstract: The present invention relates to a novel cocrystal compound of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide (rivaroxaban) and malonic acid, to processes for its preparation, to medicaments comprising this compound and to their use for controlling diseases.
    Type: Application
    Filed: June 3, 2009
    Publication date: June 23, 2011
    Applicant: Bayer Schering Pharma AG
    Inventors: Alfons Grunenberg, Karsten Fähnrich, Olaf Queckenberg, Christiane Reute, Birgit Keil, Karen Sue Gushurst, Ezra John Still
  • ENROFLOXACIN HEXAHYDRATE
    Publication number: 20110003829
    Abstract: The present invention relates to a novel hexahydrate of enrofloxacin, to processes for its preparation, to pharmaceuticals containing it, and to its use in combating diseases.
    Type: Application
    Filed: January 18, 2008
    Publication date: January 6, 2011
    Applicant: BAYER ANIMAL HEALTH GMBH
    Inventors: Alfons Grunenberg, Clemens Bothe, Birgit Keil
  • 4-[4-(amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate
    Publication number: 20100173953
    Abstract: The present invention relates to 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate, to processes for its preparation, to pharmaceutical compositions comprising it and to its use in the control of disorders.
    Type: Application
    Filed: September 29, 2007
    Publication date: July 8, 2010
    Inventors: Alfons Grunenberg, Juergen Stiehl, Katharina Tenbieg, Birgit Keil
  • NOVEL POLYMORPHOUS FORM AND THE AMORPHOUS FORM OF 5-CHLORO-N-({ (5S)-2-OXO-3[4-(3-OXO-4-MORPHOLINYL(-PHENYL]-1,3-OXAZOLIDINE-5-YL}-METHYL)-2-THIOPHENE CARBOXAMIDE
    Publication number: 20100152189
    Abstract: The present invention relates to a novel polymorphic form and the amorphous form of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophene-carboxamide, processes for their preparation, medicaments comprising these forms, and their use in the control of diseases.
    Type: Application
    Filed: September 22, 2006
    Publication date: June 17, 2010
    Applicant: BAYER HEALTHCARE AG
    Inventors: Alfons Grunenberg, Jana Lenz, Gerhard Arnold Braun, Birgit Keil, Christian R. Thomas