Patents by Inventor Birgit Knoechel

Birgit Knoechel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETING GALECTIN-9 AS A THERAPEUTIC STRATEGY FOR T-CELL EXHAUSTION IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
    Publication number: 20220242955
    Abstract: The present invention relates to compositions and methods for treating early T-cell precursor acute lymphoblastic leukemia (ETP T-ALL).
    Type: Application
    Filed: July 10, 2020
    Publication date: August 4, 2022
    Applicants: DANA-FARBER CANCER INSTITUTE, INC., THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Birgit Knoechel, Jens G. Lohr, Praveen Anand, Amy Guillaumet-Adkins, Jon Aster
  • Diagnostic and treatment methods in subjects having or at risk of developing resistance to cancer therapy
    Patent number: 9763956
    Abstract: The invention relates to methods of treatment and diagnosis of subjects with cancer. In some aspects, the invention relates to methods of treatment and diagnosis of subjects with cancer, wherein the cancer is characterized by a Notch pathway activation mutation or by resistance to a Notch pathway inhibitor.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: September 19, 2017
    Assignees: The Broad Institute, Inc., The Brigham and Women's Hospital, Inc., The General Hospital Corporation, Dana-Farber Cancer Institute, Inc.
    Inventors: Bradley E. Bernstein, Jon C. Aster, James E. Bradner, Birgit Knoechel, Christopher J. Ott, David Root
  • DIAGNOSTIC AND TREATMENT METHODS IN SUBJECTS HAVING OR AT RISK OF DEVELOPING RESISTANCE TO CANCER THERAPY
    Publication number: 20150174138
    Abstract: The invention relates to methods of treatment and diagnosis of subjects with cancer. In some aspects, the invention relates to methods of treatment and diagnosis of subjects with cancer, wherein the cancer is characterized by a Notch pathway activation mutation or by resistance to a Notch pathway inhibitor.
    Type: Application
    Filed: June 19, 2013
    Publication date: June 25, 2015
    Applicants: The Broad Institute, Inc., The Brigham and Women's Hospital, Inc., The General Hospital Corporation d/b/a Massachusetts General Hospital, Dana-Farber Cancer Institute, Inc.
    Inventors: Bradley E. Bernstein, Jon C. Aster, James E. Bradner, Birgit Knoechel, Christopher J. Ott, David Root