Patents by Inventor Birgit Manz

Birgit Manz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic oxygen transport made from cross-linked modified human or porcine haemoglobin with improved properties, method for a preparation thereof from purified material and use thereof
    Patent number: 7005414
    Abstract: According to the claims, the present invention comprises the preparation of chemically modified, cross-linked hemoglobins with improved functional properties, the cross-linked hemoglobins prepared according to this method and the use of these hemoglobins as artificial oxygen carriers. The synthesis method is characterized by technical simplicity as well as by high yields. Deoxygenated hemoglobin of high purity is conjugated covalently under the protection of an antioxidant with an effector of oxygen binding, especially with pyridoxal-5-phosphate, after which the hemoglobin is polymerized with glutardialdehyde as a bifunctional cross-linking agent. At the same time, there is a large increase in the volume of the reaction mixture and a decrease in the concentration of the hemoglobin during the addition of the cross-linking agent. Subsequently, after further dilution with water, a polyethylene oxide derivative is chemically linked to the cross-linked hemoglobins.
    Type: Grant
    Filed: June 12, 2001
    Date of Patent: February 28, 2006
    Assignee: Sanguibiotech GmbH
    Inventors: Wolfgang Barnikol, Oswald Burkhard, Harald Pötzschke, Ulrike Domack, Stephanie Dinkelmann, Bernd Fiedler, Birgit Manz
  • Synthetic oxygen transport made from cross-linked modified human or porcine haemoglobin with improved properties, method for a preparation thereof from purified material and use thereof
    Publication number: 20040029780
    Abstract: According to the claims, the present invention comprises the preparation of chemically modified, cross-linked hemoglobins with improved functional properties, the cross-linked hemoglobins prepared according to this method and the use of these hemoglobins as artificial oxygen carriers. The synthesis method is characterized by technical simplicity as well as by high yields.
    Type: Application
    Filed: August 28, 2003
    Publication date: February 12, 2004
    Inventors: Wolfgang Barnikol, Oswald Burkhard, Harald Potzschke, Ulrike Domack, Stephanie Dinkelmann, Bernd Fiedler, Birgit Manz