Patents by Inventor Birgit Piater

Birgit Piater has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPY UTILIZING DNA ALKYLATING AGENTS AND ATR INHIBITORS
    Publication number: 20210369705
    Abstract: The present invention relates to synergistic combinations of DNA-alkylating ADCs and ATR inhibitors.
    Type: Application
    Filed: October 14, 2019
    Publication date: December 2, 2021
    Applicant: Merck Patent GmbH
    Inventors: Carl DEUTSCH, Birgit PIATER, Nicolas RASCHE, Heike DAHMEN, Frank ZENKE, Astrid ZIMMERMANN, Marcel RIEKER
  • Transglutamine tag for efficient site-specific bioconjugation
    Patent number: 11130818
    Abstract: The present invention provides novel peptide sequences for use in microbial transgluatminase-mediated, in particular mTG2-mediated bioconjugations, in particular for the manufacture of antibody-drug-conjugates. Further disclosed are bioconjugation methods employing mTG2 and the novel peptide sequence motifs of the invention. The present invention further provides proteins comprising the novel sequence motifs of the invention as well as polynucleotides encoding the same.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: September 28, 2021
    Assignee: MERCK PATENT GMBH
    Inventors: Birgit Piater, Ulrich Betz, Harald Kolmar, Vanessa Siegmund
  • ANTI-C-MET ANTIBODIES AND ANTIBODY DRUG CONJUGATES THEREOF FOR EFFICIENT TUMOR INHIBITION
    Publication number: 20190248907
    Abstract: The present invention provides antibodies and heterodimeric immunoglobulin molecules, which bind cMET with high affinity and can be used to target cMET expressing tumor cells. The present invention also discloses methods of generating anti-cMET antibody drug conjugates using the inventive antibodies or heterodimeric immunoglobulin molecules as disclosed herein.
    Type: Application
    Filed: September 14, 2017
    Publication date: August 15, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Achim DOERNER, Lars TOLEIKIS, Birgit PIATER, Laura RHIEL, Christine KNUEHL, Carolin SELLMANN, Simon KRAH
  • A TRANSGLUTAMINE TAG FOR EFFICIENT SITE-SPECIFIC BIOCONJUGATION
    Publication number: 20190194344
    Abstract: The present invention provides novel peptide sequences for use in microbial transgluatminase-mediated, in particular mTG2-mediated bioconjugations, in particular for the manufacture of antibody-drug-conjugates. Further disclosed are bioconjugation methods employing mTG2 and the novel peptide sequence motifs of the invention. The present invention further provides proteins comprising the novel sequence motifs of the invention as well as polynucleotides encoding the same.
    Type: Application
    Filed: August 4, 2016
    Publication date: June 27, 2019
    Applicant: Merck Patent GmbH
    Inventors: Birgit Piater, Ulrich Betz, Harald Kolmar, Vanessa Siegmund
  • APTAMER LABELLED WITH F-19 NUCLEUS FOR TARGETED MOLECULAR IMAGING BY MRI
    Publication number: 20130289259
    Abstract: Magnetic Resonance Imaging based on 19F instead of 1H opens up new diagnostic possibilities. The 19F nucleus has a high gyromagnetic ratio (40 MHz/T) and a natural isotopic abundance ratio of 100%. In the human body, 19F containing structures are exclusively present in the form of solid salts, e.g. teeth and bones. The J2 relaxation times of the endogenous 19F atoms are extremely short and the MR signal is hardly detectable. The lack of endogenous 19F-based structures with relatively high transverse relaxation times assures a very low background MR signal. Therefore, exogenous 19F-based MRI contrast agents allow for “hot spot” imaging in a way similar to other techniques such as PET. As a useful extension of its diagnostic use, MRI is also proposed for the monitoring of the delivery of bio-active agents such as therapeutic or diagnostic agents.
    Type: Application
    Filed: December 12, 2011
    Publication date: October 31, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Ralf Guenther, Bjoern Hock, Simon Goodman, Birgit Piater