Patents by Inventor Birgitta Leuthner

Birgitta Leuthner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-substituted cyclopentylamine derivatives
    Patent number: 10118919
    Abstract: Compounds of the formula I in which R, W, R1, R4, X1, X2, X3, X4 and q have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: November 6, 2018
    Assignee: Merck Patent GmbH
    Inventors: Christos Tsaklakidis, Wolfgang Staehle, Birgitta Leuthner
  • sp. phytase variants
    Patent number: 9999238
    Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: June 19, 2018
    Assignee: DANISCO US INC
    Inventors: Oliver Kensch, Klaus Schulze Pellengahr, Birgitta Leuthner, Jayarama K Shetty, Michael J. Pepsin, Soeren Dalsgaard, Mai Faurschou Isaksen
  • BUTTIAUXELLA SP. PHYTASE VARIANTS
    Publication number: 20180125094
    Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.
    Type: Application
    Filed: June 8, 2017
    Publication date: May 10, 2018
    Inventors: OLIVER KENSCH, KLAUS SCHULZE PELLENGAHR, BIRGITTA LEUTHNER, JAYARAMA K SHETTY, Michael J. PEPSIN, SOEREN DALSGAARD, MAI FAURSCHOU ISAKSEN
  • 3-SUBSTITUTED CYCLOPENTYLAMINE DERIVATIVES
    Publication number: 20180022738
    Abstract: Compounds of the formula I in which R, W, R1, R4, X1, X2, X3, X4 and q have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: September 6, 2017
    Publication date: January 25, 2018
    Applicant: Merck Patent GmbH
    Inventors: Christos TSAKLAKIDIS, Wolfgang STAEHLE, Birgitta LEUTHNER
  • Aminostatin derivatives for the treatment of arthrosis
    Patent number: 9839665
    Abstract: The present invention relates to compounds of the formula (I) and in particular medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of arthrosis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: December 12, 2017
    Assignee: Merck Patent GmbH
    Inventors: Markus Klein, Christos Tsaklakidis, Hans Guehring, Birgitta Leuthner
  • Piperazine derivatives as FASN inhibitors
    Patent number: 9809552
    Abstract: Compounds of the formula I in which R, X1, X2, X3, X4, R1, R2 and q have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: November 7, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Wolfgang Staehle, Christos Tsaklakidis, Manja Friese-Hamim, Birgitta Leuthner, Dirk Wienke
  • 3-substituted cyclopentylamine derivatives
    Patent number: 9790216
    Abstract: Compounds of the formula I in which R, W, R1, R4, X1, X2, X3, X4 and q have the meanings indicated in claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: October 17, 2017
    Assignee: Merck Patent GmbH
    Inventors: Christos Tsaklakidis, Wolfgang Staehle, Birgitta Leuthner
  • Phthalazine derivatives
    Patent number: 9751842
    Abstract: Compounds of the formula I in which R1, X and n have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: September 5, 2017
    Assignee: Marck Patent GmbH
    Inventors: Hans-Peter Buchstaller, Dieter Dorsch, Christina Esdar, Birgitta Leuthner
  • 1,3-Disubstituted cyclopentane derivatives
    Patent number: 9718785
    Abstract: Compounds of the formula I in which R, Y, R1, X1, X2, X3 and q have the meanings indicated in claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: August 1, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Christos Tsaklakidis, Wolfgang Staehle, Birgitta Leuthner, Thomas Fuchss
  • 1,3-diaminocyclopentane carboxamide derivatives
    Patent number: 9670142
    Abstract: Compounds of the formula I in which R1, R4, R6, R, X1, X2, X3, X4, q and W have the meanings indicated in claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: June 6, 2017
    Assignee: Merck Patent GmbH
    Inventors: Christos Tsaklakidis, Wolfgang Staehle, Birgitta Leuthner, Paul Czodrowski, Thomas Fuchss
  • BUTTIAUXELLA SP. PHYTASE VARIANTS
    Publication number: 20170143004
    Abstract: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.
    Type: Application
    Filed: July 25, 2016
    Publication date: May 25, 2017
    Applicant: Danisco US Inc.
    Inventors: Oliver Kensch, Klaus Schulze Pellengahr, Birgitta Leuthner, Jayarama K. Shetty, Michael Pepsin, Soren Dalsgaard, Mai Faurschou Isaksen
  • PHTHALAZINE DERIVATIVES
    Publication number: 20160318876
    Abstract: Compounds of the formula I in which R1, X and n have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: May 30, 2014
    Publication date: November 3, 2016
    Applicant: Marck Patent GmbH
    Inventors: Hans-Peter BUCHSTALLER, Dieter DORSCH, Christina ESDAR, Birgitta LEUTHNER
  • PIPERAZINE DERIVATIVES AS FASN INHIBITORS
    Publication number: 20160280655
    Abstract: Compounds of the formula I in which R, X1, X2, X3, X4, R1, R2 and q have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: February 24, 2014
    Publication date: September 29, 2016
    Applicant: MERCK PATENT GMBH
    Inventors: Wolfgang STAEHLE, Christos TSAKLAKIDIS, Manja FRIESE-HAMIM, Birgitta LEUTHNER, Dirk WIENKE
  • Hydropyrrolopyrrole derivatives for use as fatty acid synthase inhibitors
    Patent number: 9416133
    Abstract: Compounds of the formula I in which R1, R2, R, X1, X2, X3, X4, n1, n2, n3 and n4 have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: August 16, 2016
    Assignee: MERCK PATENT GMBH
    Inventors: Wolfgang Staehle, Christos Tsaklakidis, Birgitta Leuthner, Dirk Wienke, Frank Czauderna, Ansgar Wegener
  • 3-SUBSTITUTED CYCLOPENTYLAMINE DERIVATIVES
    Publication number: 20160200714
    Abstract: Compounds of the formula I in which R, W, R1, R4, X1, X2, X3, X4 and q have the meanings indicated in claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: May 12, 2014
    Publication date: July 14, 2016
    Applicant: Merck Patent GmbH
    Inventors: Christos TSAKLAKIDIS, Wolfgang STAEHLE, Birgitta LEUTHNER
  • 1,3-DISUBSTITUTED CYCLOPENTANE DERIVATIVES
    Publication number: 20160176824
    Abstract: Compounds of the formula I in which R, Y, R1, X1, X2, X3 and q have the meanings indicated in claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: July 11, 2014
    Publication date: June 23, 2016
    Applicant: MERCK PATENT GMBH
    Inventors: Christos TSAKLAKIDIS, Wolfgang STAEHLE, Birgitta LEUTHNER, Thomas FUCHSS
  • Tetrahydro-quinazolinone derivatives as TANK and PARP inhibitors
    Patent number: 9339503
    Abstract: Compounds of the formula I in which U, V and W have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: May 17, 2016
    Assignee: MERCK PATENT GMBH
    Inventors: Hans-Peter Buchstaller, Christina Esdar, Birgitta Leuthner
  • 1,3-DIAMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES
    Publication number: 20160130214
    Abstract: Compounds of the formula I in which R1, R4, R6, R, X1, X2, X3, X4, q and W have the meanings indicated in claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: May 9, 2014
    Publication date: May 12, 2016
    Applicant: Merck Patent GmbH
    Inventors: Christos TSAKLAKIDIS, Wolfgang STAEHLE, Birgitta LEUTHNER, Paul CZODROWSKI, Thomas FUCHSS
  • Mutant citrobacter freundii phytase polypeptide
    Patent number: 9273295
    Abstract: The present invention relates to enzymes and processes. In particular, there is described an isolated polypeptide comprising the amino acid sequence corresponding to Citrobacter freundii phytase or a homologue, a modified form, a functional equivalent or an effective fragment thereof. There is also described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme or a modified form as well as the use of such a phytase or modified form in food or animal feed.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: March 1, 2016
    Assignee: DUPONT NUTRITION BIOSCIENCES APS
    Inventors: Andrei Miasnikov, Vijay Kumar, Oliver Kensch, Klaus Pellangahr, Birgitta Leuthner, Ulrich Kettling, Andre Koltermann
  • HYDROPYRROLOPYRROLE DERIVATIVES FOR USE AS FATTY ACID SYNTHASE INHIBITORS
    Publication number: 20150252046
    Abstract: Compounds of the formula I in which R1, R2, R, X1, X2, X3, X4, n1, n2, n3 and n4 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: August 30, 2013
    Publication date: September 10, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Wolfgang Staehle, Christos Tsaklakidis, Birgitta Leuthner, Dirk Wienke, Frank Czauderna, Ansgar Wegener