Patents by Inventor Birgitte Fuglsang KJOLBY

Birgitte Fuglsang KJOLBY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10660597
    Abstract: The present invention relates to a method for estimating perfusion indices (PI) in a mammal (200), e.g. a human. Data (DAT, DAT?) representative of a contrast agent concentration as a function of time of an injected contrast agent is obtained from a medical imaging system (100). Perfusion indices (PI) are found by applying a parametric model (PM) for capillary transit time distributions as a function of time, and a minorize-maximization (MM) type procedure, such as an expectation-maximization (EM) type procedure, with regularization. The minorize-maximization type procedure has an exact analytical expression for the variance of an observation error of the contrast agent (C?) in a non-linear observation model for the contrast agent concentration used in the maximization step. Clinical tests performed for 7 patients show improved MTT mapping as compared to singular value decomposition (SVD), and reduced sensitivity to delay.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: May 26, 2020
    Assignee: Aarhus Universitet
    Inventors: Kim Mouridsen, Mikkel Bo Hansen, Irene Klærke Mikkelsen, Susanne Lise Bekke, Birgitte Fuglsang Kjølby
  • Publication number: 20160228085
    Abstract: The present invention relates to a method for estimating perfusion indices (PI) in a mammal (200), e.g. a human. Data (DAT, DAT?) representative of a contrast agent concentration as a function of time of an injected contrast agent is obtained from a medical imaging system (100). Perfusion indices(PI) are found by applying a parametric model (PM) for capillary transit time distributions as a function of time, and a minorize-maximization (MM) type procedure, such as an expectation-maximization (EM) type procedure, with regularization. The minorize-maximization type procedure has an exact analytical expression for the variance of an observation error of the contrast agent (C?) in a non-linear observation model for the contrast agent concentration used in the maximization step. Clinical tests performed for 7 patients show improved MTT mapping as compared to singular value decomposition (SVD), and reduced sensitivity to delay.
    Type: Application
    Filed: September 19, 2014
    Publication date: August 11, 2016
    Inventors: Kim MOURIDSEN, Mikkel Bo HANSEN, Irene Klærke MIKKELSEN, Susanne Lise BEKKE, Birgitte Fuglsang KJOLBY
  • Publication number: 20130039553
    Abstract: The present invention relates to a method for obtaining a blood flow parameter. More particularly a method is presented wherein a first concentration curve is deconvolved with a second concentration curve and wherein a characteristic frequency is determined by an analysis in the frequency domain, the characteristic frequency being a frequency above which noise dominates the result of said deconvolution. A filter having the characteristic frequency is applied on the result of the deconvolution so as to disregard high frequency components, and the filtered result of the deconvolution is processed into a blood flow parameter. In an advantageous embodiment, the characteristic frequency may be dependent on a shape and/or width of an arterial input function and/or other parameters. The invention furthermore relates to a computer program product and a system for obtaining a blood flow parameter.
    Type: Application
    Filed: March 7, 2011
    Publication date: February 14, 2013
    Applicant: AARHUS UNIVERSITET
    Inventor: Birgitte Fuglsang Kjølby