Abstract: System and method for neuromodulation therapy of neurological and neuropsychiatric disorders comprises an implantable lead and pulse generator system for providing the appropriate electrical stimulation to a cranial nerve such as the vagus nerve. The implantable pulse generator having prepackaged/predetermined programs stored in the memory of the pulse generator, and means for accessing these with an external magnet. The pulse generator adapted to selectively activate predetermined programs with the external magnet, thereby eliminating the need for an external programmer. The elimination of the external programmer resulting in significant cost reduction with essentially the same functionality.

Abstract: A method of countering terrorism or hostile activity in an airplane by using a built-in defense system within the aircraft. The defense system includes chemical sprays, laser guns, and pre-programmed sound alarm systems. The aerosol chemicals range from benign fogging agents to non-lethal incapacitating agents from the categories of inhalants, general anesthetics, and irritants. Any of the systems can be used singly or in any combination. These systems can be activated manually from the control panel in the cockpit, or via a remote wireless system by the flight crew from anywhere within the plane. Such activation being password and code protected.

Abstract: A system and method of neuromodulation adjunct (add-on) therapy for atrial fibrillation, refractory hypertension, and inappropriate sinus tachycardia comprises an implantable lead-receiver and an external stimulator. Neuromodulation is performed using pulsed electrical stimulation. The external stimulator contains a power source, controlling circuitry, a primary coil, and predetermined programs. The primary coil of the external stimulator inductively transfers electrical signals to the implanted lead-receiver, which is also in electrical contact with a vagus nerve. The external stimulator emits electrical pulses to stimulate the vagus nerve according to a predetermined program. In a second mode of operation, an operator may manually override the predetermined sequence of stimulation. The external stimulator may also be equipped with a telecommunications module to control the predetermined programs remotely.

Abstract: A system and method for remotely controlling the stimulation therapy for neurological, neuropsychiatric and urological disorders, comprises an implantable lead-receiver and an external stimulator with two-way wireless communication capability, through a server. Proximity sensing of an implanted coil and feedback regulation of stimulation pulses is provided through an implanted magnet and circuitry in the external stimulator. The external stimulator comprises predetermined (pre-packaged) programs for neuromodulation therapy. Some of these pre-packaged programs are “locked-out” to the patient, and can be activated remotely via a server by the physician. A physician can also set up a library of the therapy programs to be executed over a set period of time. The physician can also interrogate remotely, the stimulation therapy setting on a a server or a hand-held device, through a server.

Abstract: A method and system for afferent neuromodulation of the vagus nerve for providing stimulation therapy, comprises a transmitter and an implanted stimulus receiver. The circuitry of the transmitter is capable of generating modulated high frequency pulses for delivering virtually any form, any sequence, for any time interval for various therapy application. The implanted stimulus receiver, which is in electrical connection with the vagus nerve, may be a passive or an active device. In one embodiment the implanted stimulus receiver may be a “hybrid device” which is both inductively coupled, as well as, having a power source. Therapy is provided via pre-determined program or may be “custom” adjusted for the patient. In one embodiment the external transmitter comprises a wireless communication telemetry module, whereby therapy programs may be adjusted remotely by the physician via the wireless internet.

Abstract: An apparatus and method for adjunct (add-on) therapy for dementia and Alzheimer's disease comprises an implanted lead-receiver, and an external stimulator. The implanted lead receiver comprises a secondary coil and at least one electrode in contact with a cranial nerve. The external stimulator comprises circuitry, at least two pre-determined programs, power source and a primary coil. The stimulator and the lead-receiver are inductively coupled. The external stimulator emits pulsed electrical signals according to predetermined programs for afferant vagal nerve stimulation.

Abstract: A system and method of neuromodulation adjunct (add-on) therapy for Diabetes and blood glucose regulation, comprises an implantable lead-receiver and an external stimulator. Neuromodulation is performed using a pulsed electrical stimulation. The external stimulator contains a power source, controlling circuitry, a primary coil, and predetermined programs. The primary coil of the external stimulator inductively transfers electrical signals to the lead-receiver, which is also in electrical contact with a vagus nerve. The external stimulator emits electrical pulses to stimulate the vagus nerve according to a predetermined program. The patient acts as his/her own feedback loop. In a second mode of operation, an operator may manually override the predetermined sequence of stimulation, based on meal schedule. The external stimulator may also be equipped with a telecommunications module to control the predetermined programs remotely.

Abstract: A system and method of neuromodulation adjunct (add-on) therapy for obesity and compulsive eating disorders, comprises an implantable lead-receiver and an external stimulator. Neuromodulation is performed using pulsed electrical stimulation. The external stimulator contains a power source, controlling circuitry, a primary coil, and predetermined programs which control the different levels of therapy. The primary coil of the external stimulator inductively transfers electrical signals to the lead-receiver, which is also in electrical contact with the left vagus nerve. The external stimulator emits electrical pulses to stimulate the vagus nerve according to a predetermined program. In a second mode of operation, an operator may manually override the predetermined sequence of stimulation. The predetermined programs have different levels of control, which is password protected. The external stimulator may also be equipped with a telecommunications module to control the predetermined programs remotely.

Abstract: A system and method of neuromodulation adjunct (add-on) therapy for coma and traumatic brain injury, comprises an implantable lead-receiver and an external stimulator. Neuromodulation is performed using a pulsed electrical stimulation. The external stimulator contains a power source, controlling circuitry, a primary coil, and predetermined programs. The primary coil of the external stimulator inductively transfers electrical signals to the lead-receiver, which is also in electrical contact with a vagus nerve. The external stimulator emits electrical pulses to stimulate the vagus nerve according to a predetermined program. The predetermined programs have different levels of control, which is password protected. The external stimulator may also be equipped with a telecommunications module to control the predetermined programs remotely.

Abstract: An apparatus and method for neuromodulation therapy for urinary incontinence and urological disorders comprises an implantable lead-receiver, and an external stimulator having a power source, controlling circuitry, and predetermined programs. The stimulator further includes a primary coil which inductively transfers electrical signals to the lead-receiver, which is also in electric contact with the sacral nerves. The external stimulator emits electrical pulses to stimulate the sacral plexus according to a predetermined program. In a second mode of operation, an operator may manually override the predetermined sequence of stimulation.

Abstract: A method and apparatus for proximity sensing and feedback regulation between a bodily implanted secondary coil and an external primary coil applied for generating and propagating a well-defined set of excitation signals used for nerve or muscle stimulation. The complete device is a combination of external and implantable or internal components. The internal component contains a relatively small magnet composed of materials that exhibit Giant Magneto-resistor characteristics, passive circuitry and a secondary coil. The external coil contains proximity sensor circuitry that is rigidly connected in a convenient enclosure mounted supercutaneously. Feedback information of the position of the implanted coil is provided to the pulse generation circuit and the parameters are adjusted to compensate for any variation in the position of the internal coil in order to maintain the necessary signal pattern.

Abstract: System and method of neuromodulation therapy for urinary incontinence disorders comprises a lead to selectively stimulate the sacral plexus and an implantable pulse generator for providing the appropriate pulses. The implantable pulse generator having prepackaged/predetermined programs stored in the memory of the pulse generator, and means for accessing these with an external magnet. The pulse generator adapted to selectively activate predetermined programs with the external magnet, thereby eliminating the need for an external programmer. The elimination of the external programmer resulting in significant cost reduction with essentially the same functionality.

Abstract: An external stimulator adapted to be inductively coupled with an implanted lead-receiver is designed to deliver neuromodulation therapy for disorders including depression, migraine, partial complex epilepsy, generalized epilepsy, involuntary movement disorders, dementia, obsessive compulsive disorders, urinary incontinence, neurogenic/psychogenic pain and bladder control. The external stimulator containing limited number of predetermined programs packaged into the stimulator, giving the patient or caretaker a way to adjust the therapy within confined limits, or turn the device off. The pre-packaged programs contain unique combination of pulse amplitude, pulse width, frequency of stimulation, and on-off time. The programs are capable of being modified with a programming station connected to the pulse generator with a RS232-C serial connection.

Abstract: An apparatus and method for neuromodulation therapy for urinary incontinence and urological disorders comprises an implantable lead-receiver, and an external stimulator having a power source, controlling circuitry, and predetermined programs. The stimulator further includes a primary coil which inductively transfers electrical signals to the lead-receiver, which is also in electric contact with the sacral nerves. The external stimulator emits electrical pulses to stimulate the sacral plexus according to a predetermined program. In a second mode of operation, an operator may manually override the predetermined sequence of stimulation.