Patents by Inventor Birju Shah

Birju Shah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FRET-based mesoporous silica nanoparticles for real-time monitoring of drug release
    Patent number: 9408918
    Abstract: A compound comprising: (a) a drug carrier comprising coumarin-labeled-cysteine tethered mesoporous silica nanoparticles (MSNs) loaded with a pharmaceutically active agent, and (b) a fluorescein isothiocyanate-?-cyclodextrin (FITC-?-CD) covalently linked to said cysteine and blocking the release of said pharmaceutically active agent from said nanoparticles, wherein cleavage of said covalent linkage removes said cyclodextrin and releases said pharmaceutically active agent, and said coumarin and said fluorescin form a donor-acceptor pair so that said drug carrier has a first emission wavelength when the covalent linkage is intact and the cyclodextrin said present and a second emission wavelength after cleavage of said covalent linkage to remove said cyclodextrin and release said pharmaceutically active agent.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: August 9, 2016
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Ki-Bum Lee, Jinping Lai, Birju Shah
  • Cyclodextrin-modified polyamines for delivery of therapeutic molecules
    Patent number: 8697667
    Abstract: The present invention is directed to drug delivery vehicles comprising one or more cyclodextrin moieties conjugated to a dendritic polyamine for the delivery of small molecule and protein therapeutic molecules and nucleic acid therapeutic molecules, and methods of making and using the delivery vehicles.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: April 15, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Ki-Bum Lee, Birju Shah, Prasad Subramaniam, Cheoljin Kim
  • CYCLODEXTRIN-MODIFIED POLYAMINES FOR DELIVERY OF THERAPEUTIC MOLECULES
    Publication number: 20120115962
    Abstract: The present invention is directed to drug delivery vehicles comprising one or more cyclodextrin moieties conjugated to a dendritic polyamine for the delivery of small molecule and protein therapeutic molecules and nucleic acid therapeutic molecules, and methods of making and using the delivery vehicles.
    Type: Application
    Filed: October 11, 2011
    Publication date: May 10, 2012
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Ki-Bum Lee, Birju Shah, Prasad Subramaniam, Cheoljin Kim