Patents by Inventor Bishnu De

Bishnu De has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OXIDATION-RESISTANT AAT GENE THERAPY
    Publication number: 20200102575
    Abstract: A gene therapy treatment for alpha 1-antitrypsin (AAT) deficiency is provided comprising a plasmid or viral, e.g., an AAV, vector coding for an elastase- or cathepsin G-inhibiting, oxidation-resistant human AAT with a substitution at, for example, Met358 and/or Met351.
    Type: Application
    Filed: March 29, 2018
    Publication date: April 2, 2020
    Inventors: Ronald G. Crystal, Katie Stiles, Meredith Sosulski, Stephen M. Kaminsky, Dolan Sondhi, Bishnu De, Jonathan Rosenberg
  • Disrupted adenovirus-based vaccine against drugs of abuse
    Patent number: 9682133
    Abstract: The invention is directed to an adenovirus-antigen conjugate comprising (a) a disrupted adenovirus with a coat protein and (b) an antigen conjugated to the coat protein of the disrupted adenovirus, as well as a conjugate comprising (a) a disrupted adenovirus with a coat protein and (b) an antigen conjugated to the coat protein of the disrupted adenovirus. The invention also provides a method of inducing an immune response against an antigen in a human using the aforementioned conjugates. The invention further provides an adeno-associated viral vector comprising a nucleic acid sequence which encodes an antibody directed against cocaine.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: June 20, 2017
    Assignee: CORNELL UNIVERSITY
    Inventors: Ronald G. Crystal, Bishnu De, Martin Hicks, Jonathan Rosenberg, Stephen M. Kaminsky
  • RADIOLABELING OF ADENO ASSOCIATED VIRUS
    Publication number: 20170067028
    Abstract: Provided herein are systems and methods for radiolabeling of recombinant Adeno-Associated Virus (rAAV) with radioactive iodine. Also provided are methods for in vivo imaging and treatment using the radiolabeled rAAV.
    Type: Application
    Filed: May 13, 2016
    Publication date: March 9, 2017
    Inventors: Douglas J. Ballon, Ronald G. Crystal, Stephen Kaminsky, Paresh Kothari, Bishnu De, Dolan Sondhi, Shankar Vallabhajosula, John Babich
  • DISRUPTED ADENOVIRUS-BASED VACCINE AGAINST DRUGS OF ABUSE
    Publication number: 20130011432
    Abstract: The invention is directed to an adenovirus-antigen conjugate comprising (a) a disrupted adenovirus with a coat protein and (b) an antigen conjugated to the coat protein of the disrupted adenovirus, as well as a conjugate comprising (a) a disrupted adenovirus with a coat protein and (b) an antigen conjugated to the coat protein of the disrupted adenovirus. The invention also provides a method of inducing an immune response against an antigen in a human using the aforementioned conjugates. The invention further provides an adeno-associated viral vector comprising a nucleic acid sequence which encodes an antibody directed against cocaine.
    Type: Application
    Filed: March 17, 2011
    Publication date: January 10, 2013
    Applicant: CORNELL UNIVERSITY (CCTEC)
    Inventors: Ronald G. Crystal, Bishnu De, Martin Hicks, Jonathan Rosenberg, Stephen M. Kaminsky