Patents by Inventor Bita Sahaf

Bita Sahaf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD TO DETECT THE ONSET AND TO MONITOR THE RECURRENCE OF CHRONIC GRAFT VERSUS HOST DISEASE IN TRANPLANTATION PATIENTS
    Publication number: 20180052162
    Abstract: The described invention comprises a method for detecting the onset or monitoring the recurrence of chronic graft versus host disease (cGVHD) in a transplantation patient. The method comprises isolating peripheral blood mononuclear cells (PBMCs) from the transplantation patient and analyzing the isolated PBMCs to detect a biomarker specific for a donor cell. The detection of the biomarker is indicative of the onset or recurrence of cGVHD in the transplantation patient.
    Type: Application
    Filed: April 17, 2017
    Publication date: February 22, 2018
    Inventors: David B. Miklos, Bita Sahaf, Leonore A. Herzenberg
  • Method to detect the onset and to monitor the recurrence of chronic graft versus host disease in transplantation patients
    Patent number: 9658228
    Abstract: The described invention comprises a method for detecting the onset or monitoring the recurrence of chronic graft versus host disease (cGVHD) in a transplantation patient. The method comprises isolating peripheral blood mononuclear cells (PBMCs) from the transplantation patient and analyzing the isolated PBMCs to detect a biomarker specific for a donor cell. The detection of the biomarker is indicative of the onset or recurrence of cGVHD in the transplantation patient.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: May 23, 2017
    Assignee: The Board of Trustees of the Leland University Junior University
    Inventors: David B. Miklos, Bita Sahaf, Leonore A. Herzenberg
  • Method to Detect the Onset and to Monitor the Recurrence of Chronic Graft Versus Host Disease in Transplantation Patients
    Publication number: 20140212378
    Abstract: The described invention comprises a method for detecting the onset or monitoring the recurrence of chronic graft versus host disease (cGVHD) in a transplantation patient. The method comprises isolating peripheral blood mononuclear cells (PBMCs) from the transplantation patient and analyzing the isolated PBMCs to detect a biomarker specific for a donor cell. The detection of the biomarker is indicative of the onset or recurrence of cGVHD in the transplantation patient.
    Type: Application
    Filed: March 12, 2013
    Publication date: July 31, 2014
    Inventors: David B. Miklos, Bita Sahaf, Leonore A. Herzenberg
  • Methods for activating peripheral blood mononuclear cells (PBMCs) by administering human immunodeficiency virus (HIV) Tat under physiological oxygen levels
    Patent number: 8080369
    Abstract: The present invention relates to methods to activate peripheral blood mononuclear cells. The present invention further provides methods for the identification of blocking agents of Tat protein activation of PBMCs and for identifying an active portion of a Tat polypeptide for incorporation as an immunogen in a vaccine. The present invention also provides an immunogen comprising an isolated variant of wild-type HIV Tat protein that exhibits reduced HIV priming of competent cells in comparison to the wild-type HIV Tat protein. The present invention further provides a diagnostic kit for identifying blocking agents for HIV Tat protein.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: December 20, 2011
    Assignee: The Board of Trustees of the Leland Standford Junior University
    Inventors: Lenore A. Herzenberg, Bita Sahaf
  • Compositions And Methods Using Variant Tat Proteins
    Publication number: 20090074813
    Abstract: The present invention relates to methods to activate peripheral blood mononuclear cells. The present invention further provides methods for the identification of blocking agents of Tat protein activation of PBMCs and for identifying an active portion of a Tat polypeptide for incorporation as an immunogen in a vaccine. The present invention also provides an immunogen comprising an isolated variant of wild-type HIV Tat protein that exhibits reduced HIV priming of competent cells in comparison to the wild-type HIV Tat protein. The present invention further provides a diagnostic kit for identifying blocking agents for HIV Tat protein.
    Type: Application
    Filed: August 22, 2008
    Publication date: March 19, 2009
    Inventors: Bita Sahaf, Leonore A. Herzenberg