Patents by Inventor Bit Na Yang

Bit Na Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CTLA-4-targeting trans-splicing ribozyme for delivery of chimeric antigen receptor, and use thereof
    Patent number: 10557140
    Abstract: The present invention relates to a recombinant vector, characterized by including a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4)-targeting trans-splicing ribozyme expression cassette for delivery of chimeric antigen receptor, wherein the expression cassette includes: (i) a CTLA-4-targeting trans-splicing ribozyme; and (ii) a polynucleotide encoding a chimeric antigen receptor ligated to the 3? exon of the ribozyme. The present invention also relates to a transformed cell into which the recombinant vector is introduced, a ribozyme expressed from the recombinant vector, a retrovirus expressing the ribozyme, and a T cell treated with the retrovirus.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: February 11, 2020
    Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, DANKOOK UNIVERSITY
    Inventors: Seong Wook Lee, Bit Na Yang, Sung Jin Kim, Seung Ryul Han
  • CTLA-4-TARGETING TRANS-SPLICING RIBOZYME FOR DELIVERY OF CHIMERIC ANTIGEN RECEPTOR, AND USE THEREOF
    Publication number: 20190225969
    Abstract: The present invention relates to a recombinant vector, characterized by including a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4)-targeting trans-splicing ribozyme expression cassette for delivery of chimeric antigen receptor, wherein the expression cassette includes: (i) a CTLA-4-targeting trans-splicing ribozyme; and (ii) a polynucleotide encoding a chimeric antigen receptor ligated to the 3? exon of the ribozyme. The present invention also relates to a transformed cell into which the recombinant vector is introduced, a ribozyme expressed from the recombinant vector, a retrovirus expressing the ribozyme, and a T cell treated with the retrovirus.
    Type: Application
    Filed: February 2, 2016
    Publication date: July 25, 2019
    Inventors: Seong Wook Lee, Bit Na Yang, Sung Jin Kim, Seung Ryul Han