Patents by Inventor Björn Frahm
Björn Frahm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140293734Abstract: The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.Type: ApplicationFiled: May 15, 2014Publication date: October 2, 2014Inventors: Jörg KAULING, Helmut BROD, Sebastian SCHMIDT, Martin POGGEL, Björn FRAHM, Reinhold ROSE
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Publication number: 20140080213Abstract: The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.Type: ApplicationFiled: October 7, 2013Publication date: March 20, 2014Inventors: Jörg KAULING, Helmut BROD, Sebastian SCHMIDT, Martin POGGEL, Björn FRAHM, Reinhold ROSE
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Patent number: 8602636Abstract: The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.Type: GrantFiled: April 23, 2007Date of Patent: December 10, 2013Assignee: Bayer Intellectual Property GmbHInventors: Jörg Kauling, Helmut Brod, Sebastian Schmidt, Martin Poggel, Björn Frahm, Reinhold Rose
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Publication number: 20120282677Abstract: The invention relates to a photobioreactor having illumination by light sources (light guides, LEDs) moved in rotational oscillation, and optionally membrane surfaces for gas transport moved in combination in rotational oscillation. Advantages are, inter alia, light input which is spatially homogeneous on average over time and can be adapted by means of intensity and oscillation to the culture and its density, as well as low-shear power input and optionally low-shear bubble free gasification and degassing.Type: ApplicationFiled: May 2, 2012Publication date: November 8, 2012Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Helmut BROD, Bjoern FRAHM
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Publication number: 20120234394Abstract: The invention relates to a sparger for introducing a gas or gas mixture into a liquid and to a method for sparging liquids. The sparger according to the invention comprises a cavity, a gas inlet for routing a gas into the cavity and two or more faces, which are or can be pressed onto one another in a positive fashion such that a gas pressed into the cavity through the gas inlet escapes through the gaps occurring between the pressed together faces.Type: ApplicationFiled: September 4, 2010Publication date: September 20, 2012Applicant: BAYER TECHNOLOGY SERVICES GMBHInventors: Jurl Seletzky, Joerg Kauling, Björn Frahm, Helmut Brod, Marc Jenne, Franz Schmitt
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Publication number: 20120052578Abstract: A gas-introduction system useful, for example, in biotechnology for supplying cells or microorganisms with oxygen. The gas-introduction system has a bubble column and a distributor. In the vessel there is situated a liquid medium which is to be supplied with gas. A vector is used as transport medium for the gas. The gas is introduced into the bubble column and here taken up by the vector. The vector is applied to the liquid surface via the distributor in droplet form, falls downward in the medium and releases to the medium some of the gas that has been taken up. At the bottom of the vessel is situated a collecting device in which the vector droplets coalesce and pass back into the bubble column. Disclosed are a bioreactor comprising the gas-introduction system and a method for introducing gas into a liquid medium, preferably an aqueous suspension containing cells or microorganisms.Type: ApplicationFiled: January 13, 2010Publication date: March 1, 2012Applicant: BAYER TECHNOLOGY SERVICES GMBHInventors: Joerg Kauling, Björn Frahm, Andre Pütz, Markus Schindler
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Publication number: 20110256624Abstract: The invention relates to a bioreactor, to the use of the bioreactor for culturing microorganisms or cell cultures, and also to a method for culturing microorganisms or cell cultures.Type: ApplicationFiled: December 8, 2009Publication date: October 20, 2011Applicant: BAYER TECHNOLOGY SERVICES GMBHInventors: Marc Jenne, Björn Frahm, Joerg Kauling, Helmut Brod
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Publication number: 20110165677Abstract: The invention relates to a process for reducing the amount of deposits during the culture of organisms, and in particular of cell cultures, where these have a tendency towards agglomeration or adhesion to the bioreactor and to its elements, or where these are readily susceptible to agglomeration or adhesion of cell debris or of substances.Type: ApplicationFiled: September 17, 2009Publication date: July 7, 2011Applicant: Bayer Technology Services GMBHInventors: Helmut Brod, Björn Frahm, Joerg Kauling
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Publication number: 20110097800Abstract: The invention relates to a device and a method for retaining and recirculating cells in a vessel through which flow passes continuously or batchwise. In addition, the invention relates to a method of producing a device by which cells can be retained and recirculated in a vessel through which flow passes continuously or batchwise.Type: ApplicationFiled: June 10, 2009Publication date: April 28, 2011Applicant: Bayer Technology Services GmbhInventors: Joerg Kauling, Björn Frahm, Marc Jenne, Helmut Brod, Stephan Kirchner, Arndt Braun
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Publication number: 20090180933Abstract: The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.Type: ApplicationFiled: April 23, 2007Publication date: July 16, 2009Applicant: Bayer Technology Services GmbHInventors: Jörg Kauling, Helmut Brod, Sebastian Schmidt, Martin Poggel, Björn Frahm, Reinhold Rose