Abstract: A spray-dried composition comprising an enzyme which is a ?-galactosidase having transgalactosylating activity and a maltodextrin and/or sodium chloride.

Abstract: The present disclosure provides methods, compositions, apparatuses, and kits comprising ALDC enzymes having a better stability and activity, and which further can be recovered from microorganisms in improved yields.

Abstract: A drilling rig includes a drill floor with a well center opening, a derrick having a drilling machine which is suspended above the well center opening, a pipe supply area which is arranged adjacent to the well center opening on the drill floor, and a pipe handling machine. The pipe supply area has at least one pipe rack which horizontally stores pipe sections. The pipe handling machine moves at least one of the pipe sections between a horizontal storage position in the at least one pipe rack and a vertical position or a substantially vertical position above the well center opening.

Abstract: A spray-dried composition comprising an enzyme which is a ?-galactosidase having transgalactosylating activity and a maltodextrin and/or sodium chloride.

Abstract: A method for analyzing a drilling operation includes obtaining a first set of logged operational data from the drilling operation through a first time interval, obtaining a set of operational activity dividers that delimit second time intervals within the first time interval, allocating one of a plurality of pre-defined activities to each of the second time intervals, wherein a first activity is one of the plurality of pre-defined activities, calculating a first performance indicator parameter for the second time intervals which have been allocated to the first activity, generating a time-dependent profile of the first performance indicator parameter for the second time intervals, and outputting at least one calculated value of the first performance indicator parameter to an operator. The first performance indicator parameter is calculated as a function of a duration of a respective second time interval which has been allocated to the first activity.

Abstract: The present disclosure provides methods, compositions, apparatuses and kits comprising ALDC enzymes having a better stability and activity, and which further can be recovered from microorganisms in improved yields.

Abstract: A spray-dried composition comprising an enzyme which is a ?-galactosidase having transgalactosylating activity and a maltodextrin and/or sodium chloride.

Abstract: A method for scheduling a maintenance event for a machine used in drilling which includes providing a first well plan for a first well to be drilled over a first time period (tA) and a second well plan for a second well to be drilled over a second time period (tB), controlling a first computer program module for determining a projected first duty profile for the machine in the first time period and a projected second duty profile for the machine in the second time period, controlling a second computer program module for scheduling a maintenance event (tM1) for the machine based on the projected first duty profile and the projected second duty profile, and creating a new maintenance event (tM2) at a time prior to the second time period if the maintenance event (tM1) falls within the second time period.

Abstract: A simulating system comprises an input device, intended to be operated by an operator, a simulator arrangement, and a display. The simulator arrangement is configured to read a signal representing an operation of the input device, and to simulate equipment using said input signal and pre-stored equipment characteristics. The equipment may be drilling equipment for use in offshore oil/gas exploration. The system results in a visual representation of the equipment, manipulated by the input device. The simulator arrangement comprises an equipment controller, connected to an environment simulator that provides the visual representation of the equipment. The environment simulator is connected to an object database comprising equipment objects.

Abstract: The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage including a pharmacologically active peptide sequence (X) and a stabilising petide sequence (Z) covalently bound to X.

Abstract: The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage including a pharmacologically active peptide sequence (X) and a stabilising petide sequence (Z) covalently bound to X.

Abstract: The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage comprising a pharmacologically active peptide sequence (X) and a stabilising peptide sequence (Z) of 4-20 amino acid residues covalently bound to X.

Abstract: A new and distinct cultivar of osteospermum plant named Sunny Dark Amanda, particularly characterized by its intense yellow-gold ray-floret color, with the floret tips' being a slightly darker yellow, upright growth habit, elliptic ray florets in one or two complete whorls, and its nonvariegated leaves.

Abstract: A new and distinct cultivar of osteospermum plant named Sunny Victoria, particularly characterized by spoon-shaped ray florets which generally form an hourglass shape and which when mature are a medium lavender in color at the tips and transition to a very pale lavender to nearly white at the base, upright growth habit, and its nonvariegated leaves.

Abstract: Analogues of the peptide PYY (1-36) are described in which the tertiary structure of the peptide is preserved and stabilised particularly to enhance binding and activation of the Y2 receptor by the use of cross links or rigid bends in the peptide to constrain conformationally the positions of the N-terminal part of the peptide sequence and amino acid 34. The analogues are useful in the control of food intake.

Abstract: The invention relates to isopeptides capable of modulating intracellular gap junctional communication. The invention further relates to methods of using the isopeptides to maintain or enhance such communication. In one aspect, the isopeptides are antiarrhythmic isopeptides which target the same cells targeted by AAP, AAP10, HP5, and/or functional analogs thereof, i.e. the isopeptides are able to modulate the function of these cells by agonizing or antagonizing the function of AAP, AAP10, HP5, and/or functional analogs thereof.

Abstract: GLP-2 analogues are disclosed which comprise one of more substitutions as compared to [hGly2]GLP-2 and which improved biological activity in vivo and/or improved chemical stability, e.g. as assessed in in vitro stability assays. More particularly, preferred GLP-2 analogues disclosed herein comprise substitutions at one or more of positions 8, 16, 24 and/or 28 of the wild-type GLP-2 sequence, optionally in combination with further substitutions at position 2 (as mentioned in the introduction) and one or more of positions 3, 5, 7, 10 and 11, and/or a deletion of one or more of amino acids 31 to 33 and/or the addition of a N-terminal or C-terminal stabilizing peptide sequence. The analogues are particularly useful for the prophylaxis or treatment of stomach and bowel-related disorders and for ameliorating side effects of chemotherapy.

Abstract: A new and distinct cultivar of Osteospermum plant named ‘Sunny Dark Florence’, characterized by its erect, compact growth habit, with short flower stems, nonvariegated leaves, elliptic ray florets formed in one or two complete whorls, its vibrant orange ray floret color, with the under side of the ray florets having red-purple striations at the center and tips, and its dark violet-black disc florets.

Abstract: Lysine mimetic compounds having useful pharmacological activity such as antiarrhythmic activity and desirable bioavailability properties are disclosed.

Abstract: N- or C-terminally modified small peptides having antiarrhythmic properties are disclosed, and in particular small peptides that possess improved pharmacokinetic properties such as having a reduced tendency to inhibit the activity of isozyme 3A4 of cytochrome P450 oxidase. The invention further relates to uses of said compounds in the preparation of a medicament, and to pharmaceutical compositions comprising said compounds.