Patents by Inventor Bjarne Ronfeldt Nielsen

Bjarne Ronfeldt Nielsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amylase variants
    Patent number: 9856437
    Abstract: The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency, specific activity, and solubility, in particular under production conditions.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: January 2, 2018
    Assignee: NOVOZYMES A/S
    Inventors: Carsten Andersen, Torben Vedel Borchert, Bjarne Ronfeldt Nielsen
  • ALPHA-AMYLASE AND ALPHA-AMYLASE VARIANTS
    Publication number: 20160251641
    Abstract: The invention relates to a novel Termamyl-like alpha-amylase, and Termamyl-like alpha-amylases comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic pH and/or at low Ca2+ concentrations (relative to the parent).
    Type: Application
    Filed: May 18, 2016
    Publication date: September 1, 2016
    Applicant: NOVOZYMES A/S
    Inventors: Allan Svendsen, Torben Vedel Borchert, Henrik Bisgaard-Frantzen, Helle Outtrup, Bjarne Ronfeldt Nielsen, Vibeke Skovgaard Nielsen, Lisbeth Hedegaard
  • AMYLASE VARIANTS
    Publication number: 20150152361
    Abstract: The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency, specific activity, and solubility, in particular under production conditions.
    Type: Application
    Filed: February 11, 2015
    Publication date: June 4, 2015
    Inventors: Carsten Andersen, Torben Vedel Borchert, Bjarne Ronfeldt Nielsen
  • Alpha-amylase variants
    Patent number: 8883970
    Abstract: The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency, specific activity, and solubility, in particular under production conditions.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: November 11, 2014
    Assignee: Novozymes A/S
    Inventors: Carsten Andersen, Torben Vedel Borchert, Bjarne Rønfeldt Nielsen
  • Alpha-Amylase Mutants
    Publication number: 20140200172
    Abstract: The invention relates to a novel Termamyl-like alpha-amylase, and Termamyl-like alpha-amylases comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic pH and/or at low Ca2+ concentrations (relative to the parent).
    Type: Application
    Filed: November 13, 2013
    Publication date: July 17, 2014
    Applicant: NOVOZYMES A/S
    Inventors: Allan Svendsen, Torben Vedel Borchert, Henrik Bisgaard-Frantzen, Helle Outtrup, Bjarne Ronfeldt Nielsen, Vibeke Skovgaard Nielsen, Lisbeth Hedegaard
  • Stable formulations of peptides
    Patent number: 8748376
    Abstract: Stable pharmaceutical composition comprising insulinotropic peptide.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: June 10, 2014
    Assignee: Novo Nordisk A/S
    Inventors: Svend Ludvigsen, Morten Schlein, Tine Elisabeth Gottschalk Bøving, Claude Bonde, Anne-Mette Lilleøre, Dorthe Kot Engelund, Bjarne Rønfeldt Nielsen
  • Glucoamylase variants
    Patent number: 8722369
    Abstract: The invention relates to a variant of a parent fungal glucoamylase, which exhibits altered properties, in particular improved thermal stability and/or increased specific activity.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: May 13, 2014
    Assignee: Novozymes A/S
    Inventors: Bjarne Ronfeldt Nielsen, Allan Svendsen, Henrik Pedersen, Jesper Vind, Hanne Vang Hendriksen, Torben Peter Frandsen
  • AMYLASE VARIANTS
    Publication number: 20140073553
    Abstract: The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency, specific activity, and solubility, in particular under production conditions.
    Type: Application
    Filed: November 12, 2013
    Publication date: March 13, 2014
    Applicant: Novozymes A/S
    Inventors: Carsten Andersen, Torben Vedel Borchert, Bjarne Ronfeldt Nielsen
  • Amylase variants
    Patent number: 8609811
    Abstract: The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency, specific activity, and solubility, in particular under production conditions.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: December 17, 2013
    Assignee: Novozymes A/S
    Inventors: Carsten Andersen, Torben Vedel Borchert, Bjarne Ronfeldt Nielsen
  • Alpha-Amylase Mutants
    Publication number: 20120283164
    Abstract: The invention relates to a novel Termamyl-like alpha-amylase, and Termamyl-like alpha-amylases comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic pH and/or at low Ca2+ concentrations (relative to the parent).
    Type: Application
    Filed: July 24, 2012
    Publication date: November 8, 2012
    Applicant: NOVOZYMES A/S
    Inventors: Allan Svendsen, Torben Vedel Borchert, Henrik Bisgard-Frantzen, Helle Outtrup, Bjarne Ronfeldt Nielsen, Vibeke Skovgaard Neilsen, Lisbeth Hedegaard
  • Alpha-amylase mutants
    Patent number: 8263368
    Abstract: The invention relates to a novel Termamyl-like alpha-amylase, and Termamyl-like alpha-amylases comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic pH and/or at low Ca2+ concentrations (relative to the parent).
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: September 11, 2012
    Assignee: Novozymes A/S
    Inventors: Allan Svendsen, Torben Vedel Borchert, Henrik Bisgard-Frantzen, Helle Outtrup, Bjarne Ronfeldt Nielsen, Vibeke Skovgaard Nielsen, Lisbeth Hedegaard
  • Glucoamylase Variants
    Publication number: 20120208243
    Abstract: The invention relates to a variant of a parent fungal glucoamylase, which exhibits altered properties, in particular improved thermal stability and/or increased specific activity.
    Type: Application
    Filed: March 1, 2011
    Publication date: August 16, 2012
    Applicant: Novozymes A/S
    Inventors: Bjarne Ronfeldt Nielsen, Allan Svendsen, Henrik Pedersen, Jesper Vind, Hanne Vang Hendriksen, Torben Peter Frandsen
  • AMYLASE VARIANTS
    Publication number: 20110275136
    Abstract: The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency, specific activity, and solubility, in particular under production conditions.
    Type: Application
    Filed: July 20, 2011
    Publication date: November 10, 2011
    Applicant: Novozymes A/S
    Inventors: Carsten Andersen, Torben Vedel Borchert, Bjarne Rønfeldt Nielsen
  • ANTIBODY PURIFICATION PROCESS
    Publication number: 20110105725
    Abstract: The invention concerns a method for the industrial production of antibodies.
    Type: Application
    Filed: May 15, 2009
    Publication date: May 5, 2011
    Inventors: Bjarne Rønfeldt Nielsen, Hanne Christensen, Daniel E. Rasmussen, Thomas Budde Hansen, John Strikart Nielsen, Erik Halkjaer, Rikke Christina Nielsen, Christina Jespersgaard, Arne Staby
  • Glucoamylase variants
    Patent number: 7927857
    Abstract: The invention relates to a variant of a parent fungal glucoamylase, which exhibits altered properties, in particular improved thermal stability and/or increased specific activity.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: April 19, 2011
    Assignee: Novozymes A/S
    Inventors: Bjarne Ronfeldt Nielsen, Allan Svendsen, Henrik Pedersen, Jesper Vind, Hanne Vang Hendriksen, Torben Peter Frandsen
  • Stable Formulations of Peptides
    Publication number: 20100173844
    Abstract: Stable pharmaceutical composition comprising insulinotropic peptide.
    Type: Application
    Filed: December 21, 2009
    Publication date: July 8, 2010
    Applicant: Novo Nordisk A/S
    Inventors: Svend Ludvigsen, Morten Schlein, Tine Elisabeth Gottschalk Boving, Claude Bonde, Anne-Mette Lilleore, Dorthe Kot Engelund, Bjarne Ronfeldt Nielsen
  • Alpha-Amylase Mutants
    Publication number: 20090317864
    Abstract: The invention relates to a novel Termamyl-like alpha-amylase, and Termamyl-like alpha-amylases comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic pH and/or at low Ca2+ concentrations (relative to the parent).
    Type: Application
    Filed: June 29, 2009
    Publication date: December 24, 2009
    Applicant: Novozymes A/S
    Inventors: Allan Svendsen, Torben Vedel Borchert, Henrik Bisgard-Frantzen, Helle Outtrup, Bjarne Ronfeldt Nielsen, Vibeke Skovgaard Nielsen, Lisbeth Hedegaard
  • Alpha-amylase mutants
    Patent number: 7566561
    Abstract: The invention relates to a novel Termamyl-like alpha-amylase, and Termamyl-like alpha-amylases comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic pH and/or at low Ca2+ concentrations (relative to the parent).
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: July 28, 2009
    Assignee: Novozymes A/S
    Inventors: Allan Svendsen, Torben Vedel Borchert, Henrik Bisgard-Frantzen, Helle Outtrup, Bjarne Ronfeldt Nielsen, Vibeke Skovgaard Nielsen, Lisbeth Hedegaard
  • Amylase Variants
    Publication number: 20090082246
    Abstract: The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency, specific activity, and solubility, in particular under production conditions.
    Type: Application
    Filed: September 4, 2008
    Publication date: March 26, 2009
    Applicant: Novozymes A/S
    Inventors: Carsten Andersen, Torben Vedel Borchert, Bjarne Ronfeldt Nielsen
  • Amylase variants
    Patent number: 7432099
    Abstract: The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency, specific activity, and solubility, in particular under production conditions.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: October 7, 2008
    Assignee: Novozymes A/S
    Inventors: Carsten Andersen, Torben Vedel Borchert, Bjarne Rønfeldt Nielsen