Patents by Inventor Bjoern Madsen
Bjoern Madsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11779923Abstract: The present invention relates to a microfluidic device, a method for manufacturing a microfluidic device, and a method for provision of double emulsion droplets using a microfluidic device. Furthermore, the present invention relates to an assembly configured to supply pressure to the microfluidic device for provision of double emulsion droplets. Furthermore, the present invention relates to a kit comprising a plurality of microfluidic devices and a plurality of fluids configured for use with the microfluidic device for provision of double emulsion droplets. The microfluidic device comprises a transfer conduit comprising a first transfer conduit part having a first affinity for water; and a collection conduit comprising a first collection conduit part having a second affinity for water being different from the first affinity for water. A well section and a microfluidic section of the microfluidic device are fixedly connected to each other.Type: GrantFiled: December 4, 2018Date of Patent: October 10, 2023Assignee: SAMPLIX APSInventors: Thomas Kvist, Esben Bjørn Madsen, Solène Cherre, Marie Just Mikkelsen
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Publication number: 20230270140Abstract: A betalain pigment composition from red beet plants including pre-harvest foliar spraying of an ethylene-generating compound and the use of the obtained betalain pigment composition for coloring of an edible productType: ApplicationFiled: May 10, 2023Publication date: August 31, 2023Applicants: CHR. HANSEN NATURAL COLORS A/S, UNIVERSITY OF COPENHAGENInventors: Gregorio Barba ESPIN, Henrik Vlk LUETKEN, Bjarne JOERNSGAARD, Renate Petra Brigitte MUELLER, Tsaneta DZHANFEZOVA, Stephan GLIED, Bjoern MADSEN
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Patent number: 11690389Abstract: A method for obtaining a betalain pigment composition from red beet plants comprising pre-harvest foliar spraying of an ethylene-generating compound and the use of the obtained betalain pigment composition for coloring of an edible product.Type: GrantFiled: September 21, 2018Date of Patent: July 4, 2023Assignees: UNIVERSITY OF COPENHAGEN, OTERRA A/SInventors: Gregorio Barba Espin, Henrik Vik Luetken, Bjarne Joernsgaard, Renate Petra Brigitte Mueller, Tsaneta Dzhanfezova, Stephan Glied, Bjoern Madsen
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Patent number: 11572584Abstract: The present disclosure relates to methods for enrichment or isolation of a long nucleotide fragment comprising a known nucleotide sequence element, i.e. a sequence encoding a conserved active site or domain, the method being applicable i.a. to high throughput screening for DNA fragments containing a known sequence element. The methods herein comprise the steps of forming an emulsion of multiple liquid droplets from a DNA fragment containing liquid sample, specific detection of droplets containing at least one target DNA molecule, physically selecting droplets containing at least one target DNA molecule, and performing a general amplification of the DNA molecules containing at least one target DNA molecules.Type: GrantFiled: July 6, 2020Date of Patent: February 7, 2023Assignee: SAMPLIX APSInventors: Marie Just Mikkelsen, Thomas Kvist, Esben Bjørn Madsen
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Publication number: 20220275434Abstract: The present invention relates to a system for amplification of polynucleotides from a predefined number of single cells. The system comprise a device (or part) providing the predefined number of single cells, at a previously defined inlet site (or orifice) of a cartridge (microfluidic device), and the cartridge itself. The invention further relates to a method for amplification of polynucleotides from the one or more single cells using the system to provide an emulsion of aqueous droplets wherein the nucleic acid amplification occurs. Furthermore, the present invention relates to a kit comprising a plurality of microfluidic devices and a plurality of fluids configured for use with the system and the method.Type: ApplicationFiled: July 31, 2020Publication date: September 1, 2022Inventors: MARIE JUST MIKKELSEN, ESBEN BJØRN MADSEN, Peter MOURITZEN, Thorarinn BLONDAL
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Publication number: 20220105516Abstract: A microfluidic device, a method for manufacturing a microfluidic device, and a method for provision of double emulsion droplets using a microfluidic device. Furthermore, an assembly configured to supply pressure to the microfluidic device for provision of double emulsion droplets. Furthermore, a kit comprising a plurality of microfluidic devices and a plurality of fluids configured for use with the microfluidic device for provision of double emulsion droplets.Type: ApplicationFiled: January 31, 2020Publication date: April 7, 2022Inventors: Thomas Kvist, Esben Bjørn Madsen, Soléne Cherre, Marie Just Mikkeisen
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Publication number: 20210252516Abstract: The present invention relates to a microfluidic device, a method for manufacturing a microfluidic device, and a method for provision of double emulsion droplets using a microfluidic device. Furthermore, the present invention relates to an assembly configured to supply pressure to the microfluidic device for provision of double emulsion droplets. Furthermore, the present invention relates to a kit comprising a plurality of microfluidic devices and a plurality of fluids configured for use with the microfluidic device for provision of double emulsion droplets. The microfluidic device comprises a transfer conduit comprising a first transfer conduit part having a first affinity for water; and a collection conduit comprising a first collection conduit part having a second affinity for water being different from the first affinity for water. A well section and a microfluidic section of the microfluidic device are fixedly connected to each other.Type: ApplicationFiled: December 4, 2018Publication date: August 19, 2021Inventors: Thomas KVIST, Esben Bjørn MADSEN, Solène CHERRE, Marie Just MIKKELSEN
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Patent number: 10900056Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).Type: GrantFiled: July 9, 2019Date of Patent: January 26, 2021Assignees: Danmarks Tekniske Universitet, Københavns UniversitetInventors: Birger Lindberg Møller, Bjørn Madsen, Dan Stærk, Finn Thyge Okkels, Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Kim Binderup, Mads Bennedsen, Majse Nafisi, Paiman Khorsand-Jamal, Rubini Maya Kannangara, Uffe Hasbro Mortensen, Ulf Thrane, Rasmus John Normand Frandsen
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Publication number: 20200332353Abstract: The invention relates to a method for enrichment or isolation of a long nucleotide fragment comprising a known nucleotide sequence element, i.e. a sequence encoding a conserved active site or domain, the method being applicable i.a. to high throughput screening for DNA fragments containing a known sequence element.Type: ApplicationFiled: July 6, 2020Publication date: October 22, 2020Inventors: Marie Just Mikkelsen, Thomas Kvist, Esben Bjørn Madsen
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Publication number: 20200288757Abstract: A method for obtaining a betalain pigment composition from red beet plants comprising pre-harvest foliar spraying of an ethylene-generating compound and the use of the obtained betalain pigment composition for coloring of an edible product.Type: ApplicationFiled: September 21, 2018Publication date: September 17, 2020Applicants: CHR. HANSEN NATURAL COLORS A/S, UNIVERSITY OF COPENHAGENInventors: Gregorio Barba ESPIN, Henrik Vlk LUETKEN, Bjarne JOERNSGAARD, Renate Petra Brigitte MUELLER, Tsaneta DZHANFEZOVA, Stephan GLIED, Bjoern MADSEN
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Patent number: 10738354Abstract: The invention relates to a method for enrichment or isolation of a long nucleotide fragment comprising a known nucleotide sequence element, i.e. a sequence encoding a conserved active site or domain, the method being applicable i.a. to high throughput screening for DNA fragments containing a known sequence element. The methods include, inter alia, steps of providing a liquid sample of mixed DNA molecules comprising one or more specific target DNA molecules, formation of a multiple of liquid droplets, specific detection of droplets containing at least one of the target DNA molecules, physically selecting droplets containing at least one of the target DNA molecules, and general amplification of the DNA molecules in the coalesced selected droplets.Type: GrantFiled: June 24, 2016Date of Patent: August 11, 2020Assignee: Samplix ApSInventors: Marie Just Mikkelsen, Thomas Kvist, Esben Bjørn Madsen
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Patent number: 10724012Abstract: An isolated glycosyltransferase (GT) polypeptide capable of: (I): conjugating glucose to flavokermesic acid (FK); and/or (II): conjugating glucose to kermesic acid (KA) and use of this GT to e.g. make Carminic acid.Type: GrantFiled: October 15, 2018Date of Patent: July 28, 2020Assignees: Københavns Universitet, Danmarks Tekniske UniversitetInventors: Rubini Maya Kannangara, Mads Bennedsen, Bjørn Madsen, Kim Binderup, Ulf Thrane, Rasmus John Normand Frandsen, Uffe Hasbro Mortensen, Birger Lindberg Møller, Finn Thyge Okkels
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Patent number: 10660346Abstract: The present invention relates to a composition for coloring foods, beverages, animal feeds, cosmetics or drugs comprising 1) dissolved carotenoid emulsified as an oil-in-water emulsion using a suitable emulsifier and 2) crystalline carotenoid encapsulated in a suitable hydrocolloid, making it water-dispersible and thereby miscible with the oil-in-water emulsified carotenoid fraction, mixed in a ratio of between 1:100 to 100:1. The present invention further relates to a method for preparing the coloring composition, a method for preparing a food, beverage, animal feed, cosmetic or drug and a food, beverage, animal feed, cosmetic or drug comprising the coloring composition.Type: GrantFiled: June 4, 2012Date of Patent: May 26, 2020Assignee: CHR. HANSEN NATURAL COLORS A/SInventors: Jens Moeller, Bjoern Madsen, Dorthe Lauridsen
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Publication number: 20200040367Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).Type: ApplicationFiled: July 9, 2019Publication date: February 6, 2020Inventors: Birger Lindberg Møller, Bjørn Madsen, Dan Stærk, Finn Thyge Okkels, Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Kim Binderup, Mads Bennedsen, Majse Nafisi, Paiman Khorsand-Jamal, Rubini Maya Kannangara, Uffe Hasbro Mortensen, Ulf Thrane, Rasmus John Normand Frandsen
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Patent number: 10519460Abstract: A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell.Type: GrantFiled: June 10, 2016Date of Patent: December 31, 2019Assignees: DANMARKS TENISKE UNIVESITET, KØBENHAVNS UNIVERSITET, CHR. HANSEN NATURAL COLORS A/SInventors: Rasmus John Normand Frandsen, Uffe Hasbro Mortensen, Hilde Cornelijne Coumou, Rubini Maya Kannangara, Bjørn Madsen, Majse Nafisi, Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Finn Thyge Okkels, Paiman Khorsand-Jamal, Dan Stærk, Birger Lindberg Møller
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Publication number: 20190307152Abstract: A method for obtaining an anthocyanin pigment color composition from carrot plants (preferably black carrot plants) comprising pre-harvest foliar spraying of an ethylene-releasing compound and the use of the obtained anthocyanin pigment color composition for coloring of an edible product or a pharmaceutical product.Type: ApplicationFiled: September 22, 2017Publication date: October 10, 2019Applicants: UNIVERSITY OF COPENHAGEN, Chr. Hansen Natural Colors A/SInventors: Gregorio Barba ESPIN, Henrik Vlk LUETKEN, Bjarne JOERNSGAARD, Renate Petra Brigitte MUELLER, Tsaneta DZHANFEZOVA, Stephan GLIED, Bjoern MADSEN, Finn Thyge OKKELS
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Patent number: 10415066Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).Type: GrantFiled: June 10, 2016Date of Patent: September 17, 2019Assignees: Danmarks Tekniske Universitet, Københavns UniversitetInventors: Birger Lindberg Møller, Bjørn Madsen, Dan Stærk, Finn Thyge Okkels, Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Kim Binderup, Mads Bennedsen, Majse Nafisi, Paiman Khorsand-Jamal, Rubini Maya Kannangara, Uffe Hasbro Mortensen, Ulf Thrane, Rasmus John Normand Frandsen
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Publication number: 20190127767Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).Type: ApplicationFiled: June 10, 2016Publication date: May 2, 2019Inventors: Birger Lindberg Møller, Bjørn Madsen, Dan Stærk, Finn Thyge Okkels, Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Kim Binderup, Mads Bennedsen, Majse Nafisi, Paiman Khorsand-Jamal, Rubini Maya Kannangara, Uffe Hasbro Mortensen, Ulf Thrane, Rasmus John Normand Frandsen
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Publication number: 20190048328Abstract: An isolated glycosyltransferase (GT) polypeptide capable of: (I): conjugating glucose to flavokermesic acid (FK); and/or (II): conjugating glucose to kermesic acid (KA) and use of this GT to e.g. make Carminic acid.Type: ApplicationFiled: October 15, 2018Publication date: February 14, 2019Applicants: Københavns Universitet, Danmarks Tekniske UniversitetInventors: Rubini Maya Kannangara, Mads Bennedsen, Bjørn Madsen, Kim Binderup, Ulf Thrane, Rasmus John Normand Frandsen, Uffe Hasbro Mortensen, Birger Lindberg Møller, Finn Thyge Okkels
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Publication number: 20180305709Abstract: A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell.Type: ApplicationFiled: June 10, 2016Publication date: October 25, 2018Applicants: DANMARKS TEKNISKE UNIVERSITET, KØBENHAVNS UNIVERSITET, KØBENHAVNS UNIVERSITETInventors: Rasmus John Normand FRANDSEN, Uffe Hasbro MORTENSEN, Hilde Cornelijne COUMOU, Rubini Maya KANNANGARA, Bjørn MADSEN, Majse NAFISI, Johan ANDERSEN-RANBERG, Kenneth Thermann KONGSTAD, Finn Thyge OKKELS, Paiman KHORSAND-JAMAL, Dan STÆRK, Birger Lindberg MØLLER