Abstract: The present invention relates to a compound for use in a method of treating a pathological condition selected from polycystic kidney disease, polycystic liver disease, and a combination thereof. The present invention further relates to a composition for use in a method of treating a pathological condition selected from polycystic kidney disease, polycystic liver disease, and a combination thereof.

Abstract: An earth working machine (10), in particular a road milling machine, a stabilizer, or the like, having a milling drum (30) that is mounted rotatably on a machine frame (11) and is populated or populatable on its outer circumference with working tools (31); the working tools (31) to come into contact, during working operation, with the ground that is to be worked to remove it; a drive unit (20) drives the milling drum (30) by means of a drive motor (21); an input drive shaft (33) couplable to the drive motor (21) is attached to the milling drum (30); and a ballast element, constituting a kinetic mass (57), increases the kinetic energy of the milling drum (30). The kinetic mass (57) is couplable to or decouplable from the rotatable milling drum (30), or a rotational member indirectly or directly coupled to the milling drum (30), via a shiftable coupling (55).

Abstract: The invention relates to an earth working machine (10), in particular a road milling machine, a stabilizer, or the like, having a milling drum (30) that is mounted rotatably on a machine frame (11) and is populated or populatable on its outer circumference with working tools (31); the working tools (31) being provided so as to come into contact, during working operation, with the ground that is to be worked in order to remove it; a drive unit (20) being provided which drives the milling drum (30) by means of a drive motor (21); an input drive shaft (33) that is couplable to the drive motor (21) being attached to the milling drum (30); and a ballast element, constituting a kinetic mass (57), being provided in order to increase the kinetic energy of the milling drum (30).

Abstract: A cast turbine blade having a platform and hollow blade airfoil arranged thereon, wherein the blade airfoil has a pressure-side blade wall and a suction-side blade wall that extend, along a centrally arranged curved profile centerline, from a common leading edge to a common trailing edge, and having a transition, with an outer contour profile, between the blade airfoil and the platform. The blade walls each have a locally determined blade wall thickness, wherein the turbine blade has, internally, a contour profile that partially matches the outer contour profile of the transition such that the region of the transition has an essentially constant blade wall thickness. In the transition, the contour profile at a surface section of the blade airfoil facing the leading edge is such that the blade wall thickness is increased there in comparison to the blade wall thickness of the transition away from the leading edge.

Abstract: A turbine blade having an internally cooled turbine blade airfoil in which a hollow space is divided by rib elements into at least one cooling duct carrying a coolant, wherein in at least one of the rib elements a separating tear initiating device for producing a separating tear is disposed, which extends at least partially in the longitudinal direction of the at least one rib element.

Abstract: A jet burner has a hot-gas side, which faces toward a combustion chamber during operation, and a cold-gas side, which faces away from a combustion chamber, including a base plate on which there are arranged multiple jet nozzles, wherein the base plate has at least one cooling duct, wherein the at least one cooling duct issues into a burner stage which comprises a pilot burner arranged on the base plate.

Abstract: A cast turbine blade having a platform and hollow blade airfoil arranged thereon, wherein the blade airfoil has a pressure-side blade wall and a suction-side blade wall that extend, along a centrally arranged curved profile centerline, from a common leading edge to a common trailing edge, and having a transition, with an outer contour profile, between the blade airfoil and the platform. The blade walls each have a locally determined blade wall thickness, wherein the turbine blade has, internally, a contour profile that partially matches the outer contour profile of the transition such that the region of the transition has an essentially constant blade wall thickness. In the transition, the contour profile at a surface section of the blade airfoil facing the leading edge is such that the blade wall thickness is increased there in comparison to the blade wall thickness of the transition away from the leading edge.

Abstract: A process for producing a layer system is provided wherein the layer system has at least a substrate, a ceramic layer, which is applied to a surface structured in a targeted manner, in which process the intermediate layer, in particular the metallic layer, is applied in such a way that the recesses form during the coating. By introducing recesses into a surface, the stresses in the ceramic layer on the metallic substrate are reduced in such a manner that a longer lifespan for the ceramic layer is achieved.

Abstract: A hollow blade body for a hollow blade, has a blade wall which has a pressure side which has at least one first blade connection element on the inner side thereof, and a suction side which has at least one second blade connection element diametrically opposite to the first blade connection element on the inner side thereof, wherein the first blade connection element can be engaged with at least one first rib connection element which is arranged on a first longitudinal end of an insertion rib, and the second blade connection element can be engaged with at least one second rib connection element which is arranged on a second longitudinal end of the insertion rib facing away from the first longitudinal end in such a way that the insertion rib is fixed on the hollow blade body and effects a stiffening of the hollow blade.

Abstract: A turbine blade having an internally cooled turbine blade airfoil in which a hollow space is divided by rib elements into at least one cooling duct carrying a coolant, wherein in at least one of the rib elements a separating tear initiating device for producing a separating tear is disposed, which extends at least partially in the longitudinal direction of the at least one rib element.

Abstract: A jet burner has a hot-gas side, which faces toward a combustion chamber during operation, and a cold-gas side, which faces away from a combustion chamber, including a base plate on which there are arranged multiple jet nozzles, wherein the base plate has at least one cooling duct, wherein the at least one cooling duct issues into a burner stage which comprises a pilot burner arranged on the base plate.

Abstract: A method for measuring and adjusting gaps between a rotor and a stator of a machine using a sensor is provided. The measuring is conducted when the rotor is operated at a rotational speed below a nominal rotational speed of the machine and without the machine being in operation. The adjusting of the gap is carried out as a function of at least one gap dimension of the gap. The sensor is not resistant to an operating temperature of the machine occurring in a region where the sensor is located. After completion of the measuring the machine is operated with the sensor.

Abstract: A process for producing a layer system is provided wherein the layer system has at least a substrate, a ceramic layer, which is applied to a surface structured in a targeted manner, in which process the intermediate layer, in particular the metallic layer, is applied in such a way that the recesses form during the coating. By introducing recesses into a surface, the stresses in the ceramic layer on the metallic substrate are reduced in such a manner that a longer lifespan for the ceramic layer is achieved.

Abstract: To generate a combined model for isothermal and anisothermal fatigue life of a material, multiple strain-controlled fatigue tests are performed on the material. For each test, test data is generated that includes a normalized load and a number of cycles to occurrence of crack initiation in the material under a normalized load which is a function of multiple instantaneous load levels determined at different points in time during the test. Each individual instantaneous load level is determined by normalizing a measured stress at an instant with a value of a temperature dependent property of the material corresponding to a temperature of the test at that instant. The test data from the plurality of strain-controlled tests are processed to generate a combined lifetime model defining a response of the number of cycles to occurrence of crack initiation to the normalized load.

Abstract: A method for measuring and adjusting gaps between a rotor and a stator of a machine using a sensor is provided. The measuring is conducted when the rotor is operated at a rotational speed below a nominal rotational speed of the machine and without the machine being in operation. The adjusting of the gap is carried out as a function of at least one gap dimension of the gap. The sensor is not resistant to an operating temperature of the machine occurring in a region where the sensor is located. After completion of the measuring the machine is operated with the sensor.