Abstract: An extracorporeal therapy system includes: (i) a dialysis fluid circuit including dialysis fluid preparation structure to prepare a dialysis fluid for treatment, the dialysis fluid circuit including a fresh dialysis fluid pump, a used dialysis fluid pump, and at least one filter for purifying the dialysis fluid; (ii) a blood circuit including a blood filter for use during the treatment; (iii) a blood pump operable to pump blood through the blood circuit and blood filter; (iv) a source of disinfecting fluid; and (v) a control unit operable with the dialysis fluid preparation structure and the blood pump, the control unit programmed to cause the disinfecting fluid to be delivered to and located for a duration at an area of the dialysis fluid circuit having the at least one purifying filter, and wherein during the duration the disinfecting fluid is precluded from contacting at least the fresh dialysis fluid pump.

Abstract: A control system is configured to implement a method of preparing a blood treatment apparatus (1) for blood treatment. The method comprises installing, by use of a disposable arrangement, first and second flow circuits (C1, C2) separated by a semi-permeable membrane (25), the first flow circuit (C1) being connected for fluid communication with the apparatus (1) and the second flow circuit (C2) being connected to form a closed loop that includes a sterilizing filter (46) and, optionally, a container (30). The method further comprises performing backfiltration to transfer a human-compatible fluid from the first flow circuit (C1) to the second flow circuit (C2) through the semi-permeable membrane (25), and circulating (304) the human-compatible fluid in the closed loop of second flow circuit (C2), to thereby sterilize the human-compatible fluid by the sterilizing filter (46) and, optionally, collect a resulting sterile fluid in the container (30) for later use.

Abstract: A dialysis machine configured to carry out a method and a method for draining an extracorporeal fluid circuit utilizing a dialysis machine, wherein the dialysis machine is connected to a dialyzer and said extracorporeal fluid circuit, said extracorporeal fluid circuit comprising an arterial line connectable to a patient, for drawing blood from the patient and a venous line connectable to the patient for returning blood to the patient, the method comprising: after treatment termination from said extracorporeal fluid circuit draining remaining fluid from said extracorporeal fluid circuit through the dialyzer.

Abstract: A peritoneal dialysis (“PD”) system includes a housing; a PD fluid pump housed by the housing; a filter set including a filter housing and a hydrophilic filter membrane dividing an upstream chamber from a downstream chamber; a dual lumen patient line including a fresh PD fluid lumen in fluid communication with the upstream chamber and a used PD fluid lumen in fluid communication with the downstream chamber; a pressure sensor positioned and arranged to provide a pressure sensor output indicative of pressure in the downstream chamber of the filter housing; and a control unit configured to perform a pressure integrity test on the hydrophilic filter membrane by monitoring the pressure sensor output over a period of time, the pressure sensor output indicative of a negative pressure created in the downstream chamber by the PD fluid pump. A pressure drop test for evaluating the filter membrane is also disclosed.

Abstract: A peritoneal dialysis (“PD”) system includes a PD fluid pump, a disinfection loop including the PD fluid pump, the disinfection loop including PD fluid used for disinfecting the disinfection loop, and an acid solution source positioned and arranged to supply an acid solution to the disinfection loop during disinfection using the PD fluid. The disinfection loop includes an airtrap and a pressure sensor positioned and arranged to sense PD fluid pressure during disinfection, the pressure sensor outputting to a control unit, the control unit configured to open at least one gas valve located along at least one gas line leading to an upper portion of the airtrap when the PD fluid pressure reaches or exceeds a threshold PD fluid pressure due to gas formation caused by mixing the acid solution with the PD fluid.

Abstract: A peritoneal dialysis (“PD”) system includes a PD fluid pump, a dual lumen patient line including fresh and used PD fluid lumens, a filter set in fluid communication with the fresh and used PD fluid lumens, a valve provided either with a patient's transfer set or with the filter set, and a control unit configured, after a patient drain, to (i) prompt a patient or caregiver to close the valve when the valve is a manual valve, or (ii) cause the valve to close automatically when the valve is an electrically or pneumatically controlled valve. The control unit is further configured to cause the PD fluid pump, with the valve closed, to pump fresh, heated PD fluid into the fresh PD fluid lumen to displace unheated PD fluid from the fresh PD fluid lumen, through the filter set, into the used PD fluid lumen. A corresponding method is also disclosed.

Abstract: A peritoneal dialysis (“PD”) system includes a housing, a PD fluid pump housed by the housing, and a reusable patient line extending from the housing. The reusable patient line includes a distal end configured to be connected to a patient line connector provided by the housing. The PD system also includes at least one reusable PD fluid line extending from the housing, the at least one reusable PD fluid line including a distal end configured to be connected to a PD fluid line connector provided by the housing. The PD system further includes a control unit configured to cause the PD fluid pump to apply a negative pressure to at least one of the reusable patient line or the at least one reusable PD fluid line when connected, respectively, to the patient line connector or the PD fluid line connector.

Abstract: A peritoneal dialysis (“PD”) system includes a PD machine including a housing, a PD fluid pump housed by the housing, a plurality of PD fluid lines, and a plurality of PD fluid line connectors positioned and arranged at the housing to accept distal ends of the PD fluid lines to perform a disinfection sequence. The PD system also includes a disinfection unit including a disinfection unit housing, a PD fluid line connector positioned and arranged at the disinfection unit housing for receiving one of the PD fluid lines of the PD machine for the disinfection sequence, a line extending from the disinfection unit housing for connecting to one of the PD fluid line connectors of the PD machine for the disinfection sequence, and a disinfection fluid pump housed by the disinfection unit for pumping disinfection fluid during the disinfection sequence.

Abstract: A peritoneal dialysis system includes a housing; a dialysis fluid pump housed by the housing; a patient line extendable from the housing; and a hose reel located within the housing, the hose reel configured to coil the patient line when disconnected from a patient. The patient line may be a dual lumen patient line, wherein the dual lumen patient line is coiled about the hose reel during a disinfection sequence for disinfecting the dual lumen patient line and the dialysis fluid pump.

Abstract: A control system operates (201) an apparatus for extracorporeal blood processing to extract, process and return the blood of an individual while removing fluid from the blood in accordance with a set value for ultrafiltration rate, UFR. The control system further obtains (202) sensor data representing one or more physiological parameters of the individual, and intermittently performs an optimization procedure (203) to generate the set value based on the sensor data. The optimization procedure comprises: evaluating (203A) the sensor data for detection of a limiting physiological status, LPS, sequentially controlling (203B) the apparatus in accordance with a test sequence of UFRs until the LPS is detected for a current UFR, and updating (203C) the set value based on the current UFR for use in operating the apparatus subsequent to the optimization procedure. The control system may perform a series of temporally separated optimization procedures during a treatment session to adapt the UFR to the individual.

Abstract: A peritoneal dialysis (“PD”) system having an air-aided pumping sequence is disclosed herein. In an example, a PD system includes a housing, a PD fluid pump housed by the housing, an airtrap, a fluid line extending from the airtrap, a fluid line valve positioned and arranged to operate with the fluid line, a gas line extending from an upper portion of the airtrap, and a gas line valve positioned and arranged to operate with the gas line. The system also includes a control unit configured to cause the fluid line valve to close, the gas line valve to open, and the PD fluid pump to pump gas from the airtrap into the gas line after a patient drain to create a pocket of gas in the fluid line and push residual used PD fluid towards a drain line.

Abstract: A peritoneal dialysis (“PD”) system includes a housing; a PD fluid pump housed by the housing; a dual lumen patient line extending from the housing, the dual lumen patient line including a fill lumen and a return lumen; a PD fluid fill line in fluid communication with the fill lumen and an outlet of the PD fluid pump; a PD fluid return line in fluid communication with the return lumen and an inlet of the PD fluid pump; a fill pressure sensor configured to detect PD fluid pressure along the PD fluid fill line; a return pressure sensor configured to detect PD fluid pressure along the PD fluid return line; and a control unit configured to use outputs from the fill and return pressure sensors to determine if one of the fill lumen or the return lumen of the dual lumen patient line is occluded.

Abstract: A control device for a blood treatment machine performs a connection test (50) by causing the blood treatment machine to switch (51, 53) between a first and a second operating state by reversing a blood pump so as to change a flow direction of blood through both a dialyzer and access devices connected to a patient. Based on an output signal of at least one sensor in the blood treatment machine (52, 54), the control device computes (55) an efficiency change parameter that represents a change in in-vivo clearance of the blood treatment machine during the switch of the blood treatment machine between the first and second operating states. The control device evaluates (56) the efficiency change parameter to jointly detect connection errors at the dialyzer, resulting in co-current flow of treatment fluid and blood through the dialyzer, and at the access devices, resulting in access recirculation of blood.

Abstract: A peritoneal dialysis (“PD”) system includes a housing; a dialysis fluid pump housed by the housing; a dual lumen patient line extending from the housing; a filter set including a final stage filter located along a first line, and which includes a second line in parallel with the first line, the first line in fluid communication with a first lumen of the dual lumen patient line, and the second line in fluid communication with a second lumen of the dual lumen patient line; a pressure sensor located within the housing and positioned so as to sense a static or substantially static PD fluid pressure in the second lumen while fresh PD fluid is pumped through the first lumen and the final stage filter; and a control unit configured to use the sensed static or substantially static pressure in a pressure control routine for the dialysis fluid pump.

Abstract: A peritoneal dialysis (“PD”) system includes a housing; a dialysis fluid pump housed by the housing and including a reusable pump body that accepts PD fluid for pumping; a dialysis fluid inline heater housed by the housing and including a reusable heater body that accepts PD fluid for heating; at least one reusable PD fluid line extending from the housing; at least one disinfection connector supported by the housing and configured to accept one of the at least one reusable PD fluid line; and a control unit configured to run a disinfection sequence after a PD treatment, wherein each of the at least one reusable PD fluid line is connected to one of the at least one disinfection connectors, and wherein at least one of the dialysis fluid pump or the dialysis fluid inline heater is actuated by the control unit during the disinfection sequence.

Abstract: A control system is configured to implement a method of preparing a blood treatment apparatus (1) for blood treatment. The method comprises installing, by use of a disposable arrangement, first and second flow circuits (C1, C2) separated by a semi-permeable membrane (25), the first flow circuit (C1) being connected for fluid communication with the apparatus (1) and the second flow circuit (C2) being connected to form a closed loop that includes a sterilizing filter (46) and, optionally, a container (30). The method further comprises performing backfiltration to transfer a human-compatible fluid from the first flow circuit (C1) to the second flow circuit (C2) through the semi-permeable membrane (25), and circulating (304) the human-compatible fluid in the closed loop of second flow circuit (C2), to thereby sterilize the human-compatible fluid by the sterilizing filter (46) and, optionally, collect a resulting sterile fluid in the container (30) for later use.

Abstract: An extracorporeal therapy system includes: (i) a dialysis fluid circuit including dialysis fluid preparation structure to prepare a dialysis fluid for treatment, the dialysis fluid circuit including a fresh dialysis fluid pump, a used dialysis fluid pump, and at least one filter for purifying the dialysis fluid; (ii) a blood circuit including a blood filter for use during the treatment; (iii) a blood pump operable to pump blood through the blood circuit and blood filter; (iv) a source of disinfecting fluid; and (v) a control unit operable with the dialysis fluid preparation structure and the blood pump, the control unit programmed to cause the disinfecting fluid to be delivered to and located for a duration at an area of the dialysis fluid circuit having the at least one purifying filter, and wherein during the duration the disinfecting fluid is precluded from contacting at least the fresh dialysis fluid pump.

Abstract: A filter device (10) for filtration of fluids, in particular for the dialysis of blood. The filter device (10) comprises a housing (12) having a first end (14) and a second end (16) and defining a fluid chamber (18) extending between the first end (14) and the second end (16). The filter device (10) further comprises a first lid (20) provided at the first end (14) of the housing (12) and comprising a first fluid port (22), a first compartment (24), a second compartment (26) and a first internal separating wall (28) separating the first compartment (24) from the second compartment (26). The filter device (10) further comprises a second lid (30) provided at the second end (16) of the housing (12) and comprising a second fluid port (32), a third fluid port (33), a third compartment (34), a fourth compartment (36) and a second internal separating wall (38) separating the third compartment (34) from the fourth compartment (36).

Abstract: A dialysis machine configured to carry out a method and a method for draining an extracorporeal fluid circuit utilizing a dialysis machine, wherein the dialysis machine is connected to a dialyzer and said extracorporeal fluid circuit, said extracorporeal fluid circuit comprising an arterial line connectable to a patient, for drawing blood from the patient and a venous line connectable to the patient for returning blood to the patient, the method comprising: after treatment termination from said extracorporeal fluid circuit draining remaining fluid from said extracorporeal fluid circuit through the dialyzer.

Abstract: A control device for a blood treatment machine performs a connection test (50) by causing the blood treatment machine to switch (51, 53) between a first and a second operating state by reversing a blood pump so as to change a flow direction of blood through both a dialyzer and access devices connected to a patient. Based on an output signal of at least one sensor in the blood treatment machine (52, 54), the control device computes (55) an efficiency change parameter that represents a change in in-vivo clearance of the blood treatment machine during the switch of the blood treatment machine between the first and second operating states. The control device evaluates (56) the efficiency change parameter to jointly detect connection errors at the dialyzer, resulting in co-current flow of treatment fluid and blood through the dialyzer, and at the access devices, resulting in access recirculation of blood.