Abstract: There is disclosed vectors for treating lipodystrophy and vectors for use in the treatment of lipodystrophy. In particular, the disclosure relates to gene therapy vectors capable of expressing UCP1 for the treatment of lipodystrophy.

Abstract: The present invention relates to a method for controlling vehicle lane holding for a vehicle with an electric power assisted steering by means of a steering system (100) with a steering assistance actuator and one or more controllable vehicle state actuators comprising measurement of at least one vehicle position input signal with using an on-board vision system for determination of a relative vehicle lane position in the form of a lateral lane position, a heading angle and a lane curvature, transformation of the relative vehicle lane position to a target yaw and/or lateral vehicle state, measuring at least one steering input signal, determination from said one or more measured steering input signals a torque value applied by the driver via a steering wheel (120), transformation of said torque value to a relative to the afore-mentioned target yaw and/or lateral vehicle state a driver target relative yaw and/or lateral vehicle state, adding said target yaw and/or lateral vehicle state and said driver target re

Abstract: This invention relates to a new method of treating diabetes in a population of subjects that is characterised as having severe insulin-resistant diabetes. This population is typically obese, insulin resistance and hyperglycemic and has an elevated risk of diabetic kidney disease. The compound of formula I has been found to treat high body weight, insulin resistance and hyperglycemia and to have a positive effect on microvascular perfusion in glomeruli and so is particularly suited for the treatment of this patient group.

Abstract: The present disclosure relates to a hydraulic valve arrangement comprising a first pilot operated proportional directional control valve having a first valve member that is displaceable in a first and a second axial direction for controlling direction of supply and discharge of hydraulic fluid to and from a hydraulic actuator, a first proportional electro-hydraulic control valve for controlling displacement of the first valve member in the first axial direction, a second proportional electro-hydraulic control valve for controlling displacement of the first valve member in the second axial direction, and a second pilot operated proportional control valve having a second valve member configured to be controlled by the first and second proportional electro-hydraulic control valves via a shuttle valve arrangement.

Abstract: The present disclosure relates to a hydraulic valve arrangement comprising a first pilot operated proportional directional control valve having a first valve member that is displaceable in a first and a second axial direction for controlling direction of supply and discharge of hydraulic fluid to and from a hydraulic actuator, a first proportional electro-hydraulic control valve for controlling displacement of the first valve member in the first axial direction, a second proportional electro-hydraulic control valve for controlling displacement of the first valve member in the second axial direction, and a second pilot operated proportional control valve having a second valve member configured to be controlled by the first and second proportional electro-hydraulic control valves via a shuttle valve arrangement.

Abstract: The present invention relates to a method for controlling vehicle lane holding for a vehicle with an electric power assisted steering by means of a steering system (100) with a steering assistance actuator and one or more controllable vehicle state actuators comprising measurement of at least one vehicle position input signal with using an on-board vision system for determination of a relative vehicle lane position in the form of a lateral lane position, a heading angle and a lane curvature, transformation of the relative vehicle lane position to a target yaw and/or lateral vehicle state, measuring at least one steering input signal, determination from said one or more measured steering input signals a torque value applied by the driver via a steering wheel (120), transformation of said torque value to a relative to the afore-mentioned target yaw and/or lateral vehicle state a driver target relative yaw and/or lateral vehicle state, adding said target yaw and/or lateral vehicle state and said driver target re

Abstract: The present invention relates to a method for controlling vehicle lane holding for a vehicle with an electric power assisted steering by means of a steering system (100) with a steering assistance actuator and one or more controllable vehicle state actuators comprising measurement of at least one vehicle position input signal with using an on-board vision system for determination of a relative vehicle lane position in the form of a lane curvature, transformation of the relative vehicle lane position to a target yaw and/or lateral vehicle state, measuring at least one steering input signal, determination from said one or more measured steering input signals a torque value applied by the driver via a steering wheel (120), transformation of said torque value to a relative to the afore-mentioned target yaw and/or lateral vehicle state a driver target relative yaw and/or lateral vehicle state, adding said target yaw and/or lateral vehicle state and said driver target relative yaw and/or lateral vehicle state toget

Abstract: The present invention relates to an arrangement for collection and separation of a body fluid, e.g. whole blood, for purposes of analysis of a component, e.g. plasma, of a sample of the body fluid. It comprises means for receiving a body fluid, a filter arrangement (50) comprising a separation filter arrangement for separation of the component(s) to be analysed and a detection filter in communication with the separation filter arrangement. The filter arrangement comprises a pre-filter (6) having a filter volume adapted to be capable to receive a volume of body fluid exceeding a volume of a sample to be analysed, which comprises a first portion defining a sample zone volume arranged to form a sample zone and at least one second portion defining an excess removal zone volume, forming an excess fluid removal zone the volume of which exceeds said sample zone volume.

Abstract: A hydraulic system includes one or more hydraulic subsystems that have a source of additional flow for supplying an auxiliary system. The hydraulic system may include one or more actuator systems, a boost system, and a further hydraulic system, such as a steering system. The source of additional flow for supplying the auxiliary system may include: sizing the boost system for providing both full boost function and auxiliary function, sizing the steering system for providing both full steering function and auxiliary function, utilizing available flow from an unused actuator function, and/or utilizing a selector manifold for actively selecting the source of auxiliary flow based on the flow and pressure demands of the respective hydraulic systems. Such a hydraulic system enables flow to be available to an auxiliary function regardless of the flow requirements for the actuator functions and/or other vehicle functions, while also minimizing interactions and flow disruptions to the various hydraulic subsystems.

Abstract: Provided is a system and method to generate and control hydraulic fluid flow that exceeds the fluid flow capacity of an electrically driven pump to achieve high actuator retraction/extension speeds and/or electrical flow capacity of an electrical storage system to better control electrical storage. Electric machines and hydraulic pumps generally have a maximum speed beyond which they cannot be operated at. Further, electrical storage systems typically have storage capacities and rates beyond which they cannot be operated at. While an alternate approach could be to increase the hydraulic pump displacement, thus lowering the required electric machine and pump speed to generate a certain flow, it is typically desirable to reduce pump displacement in order to reduce required electric machine torque and minimize component size and losses.

Abstract: A hydraulic system includes one or more hydraulic subsystems that have a source of additional flow for supplying an auxiliary system. The hydraulic system may include one or more actuator systems, a boost system, and a further hydraulic system, such as a steering system. The source of additional flow for supplying the auxiliary system may include: sizing the boost system for providing both full boost function and auxiliary function, sizing the steering system for providing both full steering function and auxiliary function, utilizing available flow from an unused actuator function, and/or utilizing a selector manifold for actively selecting the source of auxiliary flow based on the flow and pressure demands of the respective hydraulic systems. Such a hydraulic system enables flow to be available to an auxiliary function regardless of the flow requirements for the actuator functions and/or other vehicle functions, while also minimizing interactions and flow disruptions to the various hydraulic subsystems.

Abstract: The present invention relates to an arrangement for collection and separation of a body fluid, e.g. whole blood, for purposes of analysis of a component, e.g. plasma, of a sample of the body fluid. It comprises means for receiving a body fluid, a filter arrangement (50) comprising a separation filter arrangement for separation of the component(s) to be analysed and a detection filter in communication with the separation filter arrangement. The filter arrangement comprises a pre-filter (6) having a filter volume adapted to be capable to receive a volume of body fluid exceeding a volume of a sample to be analysed, which comprises a first portion defining a sample zone volume arranged to form a sample zone and at least one second portion defining an excess removal zone volume, forming an excess fluid removal zone the volume of which exceeds said sample zone volume.

Abstract: Presented is a system and method to control hydraulic fluid flow, more specifically throttle hydraulic fluid flow, to achieve actuator deceleration rates greater than the maximum deceleration rate of an electrically driven pump. Electric machines and electric machine inverters generally have a maximum torque and current limit beyond which they cannot be operated at. To decelerate a large inertia load for example, high electric machine torque and inverter current are required to provide the braking torque, opposing the fluid flow and pressure generated by the load and hydraulic system.

Abstract: Example embodiments presented herein are directed towards a universal printing controller, and corresponding method, for universal printing control. A universal printing controller is presented herein which may provide instructions and/or control functionality to printers of various print technologies. Based on a particular print-head type, the universal controller may choose a print technology format from a variety of different print technology formats. The universal printing controller may also provide print instructions for printing an image description based on the chosen print technology format.

Abstract: Provided is a system and method to generate and control hydraulic fluid flow that exceeds the fluid flow capacity of an electrically driven pump to achieve high actuator retraction/extension speeds and/or electrical flow capacity of an electrical storage system to better control electrical storage. Electric machines and hydraulic pumps generally have a maximum speed beyond which they cannot be operated at. Further, electrical storage systems typically have storage capacities and rates beyond which they cannot be operated at. While an alternate approach could be to increase the hydraulic pump displacement, thus lowering the required electric machine and pump speed to generate a certain flow, it is typically desirable to reduce pump displacement in order to reduce required electric machine torque and minimize component size and losses.

Abstract: Presented is a system and method to control hydraulic fluid flow, more specifically throttle hydraulic fluid flow, to achieve actuator deceleration rates greater than the maximum deceleration rate of an electrically driven pump. Electric machines and electric machine inverters generally have a maximum torque and current limit beyond which they cannot be operated at. To decelerate a large inertia load for example, high electric machine torque and inverter current are required to provide the braking torque, opposing the fluid flow and pressure generated by the load and hydraulic system.

Abstract: Example embodiments presented herein are directed towards a universal printing controller, and corresponding method, for universal printing control. A universal printing controller is presented herein which may provide instructions and/or control functionality to printers of various print technologies. Based on a particular print-head type, the universal controller may choose a print technology format from a variety of different print technology formats. The universal printing controller may also provide print instructions for printing an image description based on the chosen print technology format.

Abstract: A pressure controlling valve includes a slidable spool arranged to be spring loaded towards a neutral position. A first port and a second port are connected to allow a fluid flow through the valve. A first and a second pilot port are connected to a cavity adjacent a respective first and second end surface of the spool. The pilot ports are connected to a fluid conduit on either side of a fluid device causing a pressure drop in the fluid conduit and the fluid device is connected to one of the first or second ports. The spool is displaced against the spring load in response to a pressure difference between the first and the second pilot port, whereby a control surface of the spool is arranged to restrict the fluid flow through the valve when the control surface approaches a central cavity.

Abstract: There is provided a compound of formula (I): wherein Y has the meaning given in the description. Such compounds are potentially useful in the treatment of disorders or conditions caused by, linked to, or contributed to by, excess adiposity, such as hyperinsulinemia and type 2 diabetes.

Abstract: The invention relates to a pressure controlling valve comprising a slidable spool (102) arranged to be spring loaded towards a neutral position, wherein a first port (103) and a second port (104) are connected to allow a fluid flow through the valve. A first and a second pilot port are connected to a cavity adjacent a respective first and second end surface of the spool (102). The pilot ports (107, 108) are connected to a fluid conduit on either side of a fluid device (114; 501, 502; 601) causing a pressure drop in said fluid conduit and which fluid device (114; 501, 502; 601) is connected to one of the first or second ports. The spool (102) comprises a first and a second control surface (115, 116) located in a first and a second cavity, which are connected by a third cavity.