Patents by Inventor Bjorn M. Nilsson

Bjorn M. Nilsson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL COMPOUNDS, USE AND PREPARATION THEREOF
    Publication number: 20110098310
    Abstract: The present invention relates to compounds of the general formula (I) wherein R1, R2 and R3 are as defined herein, which can act as inhibitors of protein kinases, specially the Fms-like tyrosine kinase 3 (FLT3). The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of hematological malignancies, such as AML, MLL, T-ALL, B-ALL and CMML, myeloproliferative disorders, other proliferative disorders like cancer, autoimmune disorders and skin disorders like psoriasis and atopic dermatitis.
    Type: Application
    Filed: January 28, 2009
    Publication date: April 28, 2011
    Inventors: Annika Jenmalm Jensen, Fredrik Lehmann, Bjorn M. Nilsson, Erik Nordling, Vendela Parrow
  • Benzofuran Compounds
    Publication number: 20110015185
    Abstract: The present invention relates to compounds of formula (I): wherein P, R3, W1, and W2 are as described herein, to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds for the preparation of a medicament against 5-HT6 receptor-related disorders.
    Type: Application
    Filed: September 28, 2010
    Publication date: January 20, 2011
    Applicant: BIOVITRUM AB
    Inventors: Gary Johansson, Peter Brandt, Björn M. Nilsson
  • Benzofuran compounds
    Patent number: 7820675
    Abstract: The present invention relates to compounds of formula (I): wherein P, R3, W1, and W2 are as described herein, to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds for the preparation of a medicament against 5-HT6 receptor-related disorders.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: October 26, 2010
    Assignee: Biovitrum AB
    Inventors: Gary Johansson, Peter Brandt, Björn M. Nilsson
  • 4-substituted indole and indoline compounds
    Patent number: 7812017
    Abstract: The present invention relates to novel compounds of formula (I): wherein m, n, R0, R1, R2, R3 and R4 are as described herein, to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds for the preparation of a medicament against 5-HT6 receptor-related disorders.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: October 12, 2010
    Assignee: Biovitrum AB (publ.)
    Inventors: Johan Angbrant, Rune Ringom, Kristin Hammer, Erik Ringberg, Bengt Lindqvist, Gary Johansson, Peter Brandt, Katarina Beierlein, Björn M Nilsson
  • Compounds, their use and preparation
    Patent number: 7524839
    Abstract: The invention-provides 2, 3-, 4- or 5-substituted-N1-(arylsulfonyl)indole and (heteroaryl)indole compounds of the general formula (I): in which Ar, R2, R3, R4 and R5 are as defined in the specification. The compounds bind to the 5-HT6 receptor and are useful for the treatment and prophylaxis of disorders mediated by the 5-HT6 receptor, such as obesity and CNS disorders.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: April 28, 2009
    Inventors: Patrizia Caldirola, Björn M. Nilsson, Gary Johansson
  • Pyrimidine compounds and their use
    Patent number: 7247633
    Abstract: A compound of the general formula (I): wherein R1, R2, X, Y and Z are as described in the specification.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: July 24, 2007
    Assignee: Biovitrum AB
    Inventor: Björn M. Nilsson
  • Amino-substituted 1H-pyrazin-2-ones and 1H-quinoxalin-2-ones
    Patent number: 7244722
    Abstract: Compounds of the general formula (I): wherein m, n, R1, R2, R3 and R4 are as described in the specification. Further included are pharmaceutical compositions comprising the compounds, processes for their preparation, as well as the use of the compounds for the preparation of a medicament for the treatment of 5-HT2A receptor-related disorders or medical conditions.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: July 17, 2007
    Assignee: Biovitrum AB
    Inventors: Magnus Cernerud, Helena Lundström, Björn M Nilsson, Markus Thor
  • Compounds and their use
    Patent number: 7229997
    Abstract: Compounds of the general formula (I): wherein R1, R2, R3 and R4 are as described in the specification. Further included are pharmaceutical compositions comprising the compounds, processes for their preparation, as well as the use of the compounds for the preparation of a medicament which particularly acts on the central nervous system, particularly for use as anti-obesity agents.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: June 12, 2007
    Assignee: Biovitrum AB
    Inventors: Björn M. Nilsson, Erik Ringberg
  • Compounds, their use and preparation
    Patent number: 7226925
    Abstract: The invention relates to compounds of the general Formula (I): The compounds may be prepared by per se conventional methods and can be used for treating a human or animal subject suffering from a serotonin-related disorder. The invention also relates to such use as well as to pharmaceutical compositions comprising a compound of Formula (I).
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: June 5, 2007
    Assignee: Biovitrum AB
    Inventors: Björn M. Nilsson, Erik Ringberg, Birger Sjöberg, Mattias Jönsson
  • Compounds, their use and preparation
    Patent number: 7087750
    Abstract: The invention provides 2, 3-, 4- or 5-substituted-N1-(arylsulfonyl)indole and (heteroaryl)indole compounds of the general formula (I): in which Ar, R2, R3, R4 and R5 are as defined in the specification. The compounds bind to the 5-HT6 receptor and are useful for the treatment and prophylaxis of disorders mediated by the 5-HT6 receptor, such as obesity and CNS disorders.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: August 8, 2006
    Assignee: Biovitrum AB
    Inventors: Patrizia Caldirola, Björn M. Nilsson, Gary Johansson
  • Pharmaceutical combination formulation and method of treatment with the combination
    Patent number: 6818639
    Abstract: The invention relates to method of preventing or treating a disease related to the 5-HT2C receptor and the 5-HT6 receptor, comprising administering to a human or animal subject in need thereof a 5-HT2C receptor agonist and a 5-HT6 receptor antagonist in sufficient amounts to provide a therapeutic effect. The invention also relates to a pharmaceutical composition comprising an effective amount of a combination of a 5-HT2C receptor agonist and a 5-HT6 receptor antagonist, and optionally a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: November 16, 2004
    Assignee: Biovitrum AB
    Inventors: Jossan Sukhwinder, Björn M. Nilsson, Kjell S. Sakariassen, Jan Svartengren
  • Compounds and their use
    Patent number: 6756377
    Abstract: The invention relates to compounds of the general formula (I) wherein R1, R2 and R3 are as described in the specification, which compounds are ligands to the serotonin 5-HT2c receptor.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: June 29, 2004
    Assignee: Biovitrum AB
    Inventors: Björn M. Nilsson, Martin Scobie
  • Compounds
    Publication number: 20040063693
    Abstract: Compounds of the general formula (I): 1
    Type: Application
    Filed: July 17, 2003
    Publication date: April 1, 2004
    Inventors: Magnus Cernerud, Helena Lundstrom, Bjorn M. Nilsson, Markus Thor
  • Novel compounds, their use and preparation
    Publication number: 20040029888
    Abstract: The invention relates to compounds of the general Formula (I): 1
    Type: Application
    Filed: June 18, 2003
    Publication date: February 12, 2004
    Inventors: Bjorn M. Nilsson, Erik Ringberg, Birger Sjoberg, Mattias Jonsson
  • Novel compounds and their use
    Publication number: 20040014767
    Abstract: A compound of the general formula (I): 1
    Type: Application
    Filed: July 14, 2003
    Publication date: January 22, 2004
    Applicant: Biovitrum AB, a Swedish corporation
    Inventor: Bjorn M. Nilsson
  • Novel compounds and their use
    Publication number: 20030232814
    Abstract: Compounds of the general formula (I): 1
    Type: Application
    Filed: May 16, 2003
    Publication date: December 18, 2003
    Inventors: Bjorn M. Nilsson, Erik Ringberg
  • Compounds and their use
    Patent number: 6593330
    Abstract: A compound of the general formula (I): wherein R1, R2, X, Y and Z are as described in the specification.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: July 15, 2003
    Assignee: Biovitrum
    Inventor: Björn M. Nilsson
  • Novel compounds, their use and preparation
    Publication number: 20020165251
    Abstract: The invention provides 2, 3-, 4- or 5-substituted-N1-(arylsulfonyl)indole and (heteroaryl)indole compounds of the general formula (I): 1
    Type: Application
    Filed: October 22, 2001
    Publication date: November 7, 2002
    Inventors: Patrizia Caldirola, Bjorn M. Nilsson, Gary Johansson
  • Novel compounds and their use
    Publication number: 20020147200
    Abstract: A compound of the general formula (I): 1
    Type: Application
    Filed: November 20, 2001
    Publication date: October 10, 2002
    Inventor: Bjorn M. Nilsson
  • Novel compounds and their use
    Publication number: 20020103204
    Abstract: The invention relates to compounds of the general formula (I) 1
    Type: Application
    Filed: November 19, 2001
    Publication date: August 1, 2002
    Inventors: Bjorn M. Nilsson, Martin Scobie