Patents by Inventor Bjorn Riefke
Bjorn Riefke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100129293Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: January 26, 2010Publication date: May 27, 2010Applicant: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Bjórn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 7655217Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: GrantFiled: March 22, 2006Date of Patent: February 2, 2010Assignee: Institut fur Diagnosikforschung GmbHInventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 7445767Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: GrantFiled: March 22, 2006Date of Patent: November 4, 2008Assignee: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Publication number: 20060165598Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: March 22, 2006Publication date: July 27, 2006Applicant: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Publication number: 20060165599Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: March 22, 2006Publication date: July 27, 2006Applicant: Institut fur Diagnostikforschung GmbHInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 7025949Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: GrantFiled: May 7, 2001Date of Patent: April 11, 2006Assignee: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 6926885Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: GrantFiled: June 26, 2002Date of Patent: August 9, 2005Assignees: Institut fur Diagnostikforschung GmbH, Freien Universitat BerlinInventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Publication number: 20050169844Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: March 29, 2005Publication date: August 4, 2005Applicant: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 6913743Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: GrantFiled: February 19, 2003Date of Patent: July 5, 2005Assignee: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Publication number: 20050106106Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: December 16, 2004Publication date: May 19, 2005Applicant: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Publication number: 20030170179Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: February 19, 2003Publication date: September 11, 2003Applicant: Institut fur Diagnostikforschung GMBH an der freien Universita (copy)Inventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 6534041Abstract: The invention relates to acid-labile and enzymatically divisible compounds for in-vivo and in-vitro diagnosis by means of near infrared radiation (NIR-radiation), the use of said compounds as optic diagnostic and therapeutic agents, and the diagnostic agents containing said compounds.Type: GrantFiled: May 1, 2000Date of Patent: March 18, 2003Assignee: Institute for Diagnostic Research GmbH of the Free University of BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Wolfgang Wrasidlo
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Publication number: 20030026763Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: June 26, 2002Publication date: February 6, 2003Applicant: Institut Fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christopher -Stephen Hilger
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Publication number: 20020022004Abstract: This invention relates to colloidal systems charged with polymethine dyes and having suitable photophysical and pharmacological properties, their use as a contrast medium in fluorescence and transillumination diagnostics in the near infrared spectral range, as well as methods for their production.Type: ApplicationFiled: September 25, 2001Publication date: February 21, 2002Inventors: Kai Licha, Bjorn Riefke, Werner Weitschiess, Dieter Heldmann, Violetta Sudmann
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Publication number: 20010055567Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: May 7, 2001Publication date: December 27, 2001Applicant: Institut Fur Diagnostikforschung GmbH An Der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 6329531Abstract: The invention relates to compounds of formula (I): Fm(—A1)(—Bn)(—Wo) wherein F is a colorant-signal molecule with a maximum absorption value ranging from 600-1200 nm; A is a &bgr;-amyloid plaque binding biomolecule; B is a &bgr;-amyloid plaque binding colorant; and W is a &bgr;-amyloid plaque binding hydrophilic low-molecular structural element. The invention also describes the use of these compounds in in vivo an din vitro diagnosis of neurodegenerative diseases such as Alzheimer's disease by means of near infra-red radiation (NIR radiation) as a constrasting agent in fluoresecence and transillumination diagnosis in the NIR range. Diagnostic agents containing said componenets are also disclosed.Type: GrantFiled: November 18, 1999Date of Patent: December 11, 2001Assignee: Schering AGInventors: Jonathan Turner, Thomas Dyrks, Wolfhard Semmler, Kai Licha, Bjorn Riefke
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Patent number: 6319488Abstract: This invention relates to colloidal systems charged with polymethine dyes and having suitable photophysical and pharmacological properties, their use as a contrast medium in fluorescence and transillumination diagnostics in the near infrared spectral range, as well as methods for their production.Type: GrantFiled: April 9, 1998Date of Patent: November 20, 2001Assignee: Institut für Diagnostikforschung GmbH an der Freien Universität BerlinInventors: Kai Licha, Björn Riefke, Werner Weitschiess, Dieter Heldmann, Violetta Sudmann
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Patent number: 6258340Abstract: This invention relates to a in-vivo diagnostic method based on near infrared ra ation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: GrantFiled: March 6, 2000Date of Patent: July 10, 2001Assignees: Institut fur Diagnostikforschung GmbH, der Freien Universitat BerlinInventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 6083485Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: GrantFiled: November 7, 1997Date of Patent: July 4, 2000Assignees: Institut fur Diagnostikforschung GmbH, der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger