Abstract: The present invention relates to the pharmaceutically-induced enhancement of DNA damage repair in cells and potential therapeutic applications thereof. In particular, the present invention is directed to an inhibitor of DREAM complex assembly and/or function for use in repairing DNA damage in a cell of a subject. The inhibitor of DREAM complex assembly may be an inhibitory nucleic acid inhibiting the expression of a component of the DREAM complex or an antibody to a component of the DREAM complex. Further disclosed is an inhibitor of DREAM complex assembly and/or function for use in treating and/or preventing a condition associated with DNA damage in a cell in a subject, such as age-related diseases and symptoms of ageing, a progeroid syndrome, acute radiation syndrome, chronic radiation syndrome, Xeroderma pigmentosum, Nijmegen breakage syndrome, Fanconi anemia and ataxia.

Abstract: A rubber-sprung wheel for rail vehicles includes a wheel tire which is connected to a wheel rim by a rubber insert that is formed by two flat rings that are arranged so as to be essentially vertical in relation to a wheel axle. The two flat rings are held, under considerable axial prestress, between an inner circumferential middle web of the wheel tire and two outer flanges of the wheel rim. At least one of the flanges is seated on the wheel rim with an interference fit that is designed as a conical press fit, such that a cone of the flange in a stress-free state has a lesser conicity than does a cone of the wheel rim, and in a pressed-on state rests on an entire surface against the cone of the wheel rim, at an even surface pressure across an entire width of the interference fit.

Abstract: A rubber-sprung rail vehicle wheel which is designed in particular, but not exclusively, for rail vehicles with a low design height is described. In this rail vehicle wheel, the wheel tire (2) is connected to the wheel rim (3) by way of a rubber insert that is formed by two flat rings (11, 12) that are arranged so as to be essentially vertical in relation to the wheel axle. The rings (11, 12) are held, under very considerable axial prestress, between an inner circumferential middle web (5) of the wheel tire (2) and two outer flanges (6, 8) of the wheel rim (3). At least one of the flanges (8) is seated on the wheel rim (3) with an interference fit (9) that is designed as a conical press fit.