Patents by Inventor Blaine M. Sutton

Blaine M. Sutton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing auranofin
    Patent number: 4200738
    Abstract: A new synthesis of auranofin comprising reacting 2,3,4,6-tetra-O-acetyl-.alpha.-D-glucopyranosyl bromide with a S-(triethylphosphineaurous)thiouronium salt.
    Type: Grant
    Filed: April 21, 1977
    Date of Patent: April 29, 1980
    Assignee: SmithKline Corporation
    Inventors: David T. Hill, Blaine M. Sutton, Ivan Lantos
  • Process and intermediate for preparing auranofin
    Patent number: 4133952
    Abstract: The S-gold salt of 2,3,4,6-tetra-O-acetyl-1-thio-.beta.-D-glucopyranose reacts with triethylphosphine in an organic solvent to produce auranofin.
    Type: Grant
    Filed: June 10, 1977
    Date of Patent: January 9, 1979
    Assignee: SmithKline Corporation
    Inventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
  • Method for preparing auranofin
    Patent number: 4131732
    Abstract: A new synthesis of auranofin comprising reacting 2,3,4,6-tetra-O-acetyl-.alpha.-D-glucopyranosyl bromide with triethylphosphinegold(I) chloride and sodium or potassiumsulfide. Auranofin is an antiarthritic pharmaceutical compound. Auranofin is an orally active therapeutic agent which is useful in man as an antiarthritic.
    Type: Grant
    Filed: April 21, 1977
    Date of Patent: December 26, 1978
    Assignee: SmithKline Corporation
    Inventors: David T. Hill, Blaine M. Sutton, Ivan Lantos
  • Process for preparing auranofin
    Patent number: 4125711
    Abstract: Auranofin is prepared by reacting 1-.beta.-D-thio-2,3,4,6-tetra-O-acetylglucose with a triethylphosphine gold mercaptide.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: November 14, 1978
    Assignee: Smithkline Corporation
    Inventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
  • Method for preparing auranofin
    Patent number: 4125710
    Abstract: Bis(triethylphosphine)gold salts are advantageous agents for preparing auranofin.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: November 14, 1978
    Assignee: Smithkline Corporation
    Inventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
  • Preparation of auranofin by O-acetylation
    Patent number: 4124759
    Abstract: Auranofin is prepared by direct O-acetylation of S-triethylphosphinegold 1-thio-.beta.-D-glucopyranoside.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: November 7, 1978
    Assignee: SmithKline Corporation
    Inventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
  • Process for preparing auranofin
    Patent number: 4122254
    Abstract: Auranofin and its congeners are prepared by the reaction of a S-substituted 2,3,4,6-tetra-O-acetyl-1-thio-.beta.-D-glucopyranose with a tertiary phosphine gold ester or sulfide.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: October 24, 1978
    Assignee: SmithKline Corporation
    Inventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
  • Method for preparing auranofin
    Patent number: 4115642
    Abstract: Auranofin and its congeners are prepared by reacting a bis(polyacetylsaccharide)disulfide with a tertiary phosphinegold mercaptide in a suitable organic solvent.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: September 19, 1978
    Assignee: SmithKline Corporation
    Inventors: David T. Hill, Ivan Lantos, Blaine M. Sutton
  • Anti-arthritic 1H-pyrimido-(5,4,3-kl)phenothiazine-1,3(2H)-diones and 1-thiones
    Patent number: 3962438
    Abstract: 1H-Pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-diones are prepared from the corresponding 1-thione-3-one compounds by methylation followed by acid hydrolysis. The 1,3-dione products and 1-thione-3-one intermediates are useful as anti-arthritic agents.
    Type: Grant
    Filed: January 7, 1975
    Date of Patent: June 8, 1976
    Assignee: SmithKline Corporation
    Inventors: Charles E. Berkoff, Blaine M. Sutton, Joseph Weinstock
  • Anti-arthritic compositions comprising s-heterocyclic derivatives of phosphine or phosphite gold mercaptides and methods of producing anti-arthritic activity
    Patent number: 3947565
    Abstract: S-Heterocyclic derivatives of phosphine or phosphite gold mercaptides having anti-arthritic activity are disclosed.
    Type: Grant
    Filed: January 22, 1975
    Date of Patent: March 30, 1976
    Assignee: SmithKline Corporation
    Inventors: Blaine M. Sutton, Joseph Weinstock
  • Ester derivatives of pulvinic acid
    Patent number: 3944571
    Abstract: Pharmaceutical compositions having anti-arthritic activity comprising an ester derivative of pulvinic acid and methods of producing anti-arthritic activity by administering internally said compositions. Certain of the pulvinic acid derivatives are novel compounds per se.
    Type: Grant
    Filed: May 6, 1974
    Date of Patent: March 16, 1976
    Assignee: SmithKline Corporation
    Inventors: Blaine M. Sutton, Donald T. Walz, James W. Wilson