Abstract: A method for treating a target vascular portion of a subject including: providing an angioplasty balloon system including a balloon carrying a first therapeutic agent and a second therapeutic agent on a surface of the balloon, wherein the first therapeutic agent is an anti-proliferative or anti-mitotic agent and the second therapeutic agent is a drug that aids in vascular healing on a surface of the balloon; positioning the balloon proximate the target vascular portion; expanding the balloon to engage the target vascular portion; thereby delivering at least a portion of the active agent to the target vascular portion; and withdrawing the balloon from the subject.

Abstract: Catheters for ablation and removal of occlusions from blood vessels are provided. Laser cutting systems and mechanical cutting systems are provided in catheter devices, the cutting systems operable to ablate, cut, dislodge, and otherwise remove occlusions within a blood vessel that may limit or prevent proper circulation. Catheters include expandable distal ends to facilitate, in some cases, relatively high bodily material removal rates compared to other devices.

Abstract: Methods and devices for separating an implanted object, such as a pacemaker lead, from tissue surrounding such object in a patient's vasculature system. Specifically, the tissue separating device includes a handle, an elongate sheath and a circular cutting blade that may extend from the distal end of the sheath upon actuating the handle. The elongate sheath, particularly its distal end, includes a non-uniform wall thickness having one or more thicker portions in the outer sheath, particularly the outer cam member, and/or one or more thicker portions in an inner member disposed radially inward of the blade.

Abstract: A method for treating a stenosis includes providing a laser ablation system including a laser catheter, the laser catheter including a distal end having a plurality of laser emitters; positioning the distal end of the laser catheter within the subject proximate the target vascular portion; delivering laser energy to the laser catheter and emitting the laser energy from the plurality of laser emitters to ablate the stenosis; withdrawing the laser catheter from the subject; providing a balloon system including a drug-coated balloon, the balloon carrying at least one therapeutic agent, the therapeutic agent being a restenosis inhibitor; positioning the balloon within the subject proximate the target vascular portion; expanding the balloon to engage the target vascular portion; delivering the therapeutic agent from the balloon to the target vascular portion; delivering the therapeutic agent from the balloon to the target vascular portion; and withdrawing the balloon from the subject.

Abstract: A care unit can include a base member and a plurality of petal members. Each petal member can extend from a first end, engaged with the base member, to a second end, spaced from the base member. Inward-facing surfaces of at least two petal members and the base member can collectively define a cavity for receiving at least a portion of the patient. The care unit can further include one or both of a therapy component, configured to provide a treatment to the patient, or a sensor component, configured to monitor a condition of the patient. The therapy component can be coupled to, or integrated with, one or both of the base member or a petal member and can include an optical light source, a thermal energy source, an oxygen or air source, a sound wave source, a sound wave-cancelling source, or a pulsating source, for example.

Abstract: A method for treating a target vascular portion of a subject including: providing an angioplasty balloon system including a balloon carrying a first therapeutic agent and a second therapeutic agent on a surface of the balloon, wherein the first therapeutic agent is an anti-proliferative or anti-mitotic agent and the second therapeutic agent is a drug that aids in vascular healing on a surface of the balloon; positioning the balloon proximate the target vascular portion; expanding the balloon to engage the target vascular portion; thereby delivering at least a portion of the active agent to the target vascular portion; and withdrawing the balloon from the subject.

Abstract: A method for treating a target vascular portion of a subject including: providing an angioplasty balloon system including a balloon, the balloon carrying a first polymer, a second polymer, and at least one active agent on a surface of the balloon, the at least one active agent being at least partially contained within at least one of the first polymer and the second polymer, wherein the first polymer and the second polymer having different stereoisoisomeric forms that can co-crystalize to form a stereocomplex between the first and second polymers; positioning the balloon proximate the target vascular portion; expanding the balloon to engage the target vascular portion; thereby delivering at least a portion of the active agent to the target vascular portion; and withdrawing the balloon from the subject.

Abstract: Catheters for ablation and removal of occlusions from blood vessels are provided. Laser cutting systems and mechanical cutting systems are provided in catheter devices, the cutting systems operable to ablate, cut, dislodge, and otherwise remove occlusions within a blood vessel that may limit or prevent proper circulation. Catheters include expandable distal ends to facilitate, in some cases, relatively high bodily material removal rates compared to other devices.

Abstract: Methods and devices for separating an implanted object, such as a pacemaker lead, from tissue surrounding such object in a patient's vasculature system. Specifically, the tissue separating device includes a handle, an elongate sheath and a circular cutting blade that may extend from the distal end of the sheath upon actuating the handle. The elongate sheath, particularly its distal end, includes a non-uniform wall thickness having one or more thicker portions in the outer sheath, particularly the outer cam member, and/or one or more thicker portions in an inner member disposed radially inward of the blade.

Abstract: Care units and related methods providing a comfortable environment for a patient are disclosed. A care unit can include a base member and a plurality of petal members. Each petal member can extend from a first end, engaged with the base member, to a second end, spaced from the base member. Inward-facing surfaces of at least two petal members and the base member can collectively define a cavity for receiving at least a portion of the patient. The care unit can further include one or both of a therapy component, configured to provide a treatment to the patient, or a sensor component, configured to monitor a condition of the patient. The therapy component can be coupled to, or integrated with, one or both of the base member or a petal member and can include an optical light source, a thermal energy source, an oxygen or air source, a sound wave source, a sound wave-cancelling source, or a pulsating source, for example.