Patents by Inventor Blaise N'Zemba

Blaise N'Zemba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture
    Patent number: 8138221
    Abstract: The present invention relates to pharmaceutically acceptable crystalline and amorphous salts of D-isoglutamyl-D-tryptophan as well as processes for their manufacture, pharmaceutical compositions comprising them, and their uses in the preparation of pharmaceutical compositions for the treatment of various conditions and/or diseases. In particular, the present invention relates to D-isoglutamyl-D-tryptophan potassium salt (1:1), D-isoglutamyl-D-tryptophan lithium salt (1:1), D-isoglutamyl-D-tryptophan calcium salt (2:1), D-isoglutamyl-D-tryptophan magnesium salt (2:1), and D-isoglutamyl-D-tryptophan organic ammonium salts (1:1).
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: March 20, 2012
    Inventors: Tim Fat Tam, Blaise N'Zemba, Regis Leung-Toung, Yingsheng Wang, Yanqing Zhao, Lily Yu
  • Crystalline D-isoglutamyl-D-tryptophan and the mono ammonium salt of D-isoglutamyl-D-tryptophan
    Patent number: 8119606
    Abstract: A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D-tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1:1) is a stable pharmaceutical solid.
    Type: Grant
    Filed: November 26, 2007
    Date of Patent: February 21, 2012
    Assignee: Apotex Technologies
    Inventors: Tim Fat Tam, Blaise N'Zemba, Regis Leung-Tuong, Yingsheng Wang, Yanqing Zhao, Lily Yu
  • Pharmaceutically Acceptable Salts of Thymodepressin and Processes for their Manufacture
    Publication number: 20100056803
    Abstract: The present invention relates to pharmaceutically acceptable crystalline and amorphous salts of D-isoglutamyl-D-tryptophan as well as processes for their manufacture, pharmaceutical compositions comprising them, and their uses in the preparation of pharmaceutical compositions for the treatment of various conditions and/or diseases. In particular, the present invention relates to D-isoglutamyl-D-tryptophan potassium salt (1:1), D-isoglutamyl-D-tryptophan lithium salt (1:1), D-isoglutamyl-D-tryptophan calcium salt (2:1), D-isoglutamyl-D-tryptophan magnesium salt (2:1), and D-isoglutamyl-D- tryptophan organic ammonium salts (1:1).
    Type: Application
    Filed: December 13, 2007
    Publication date: March 4, 2010
    Applicant: APOTEX TECHNOLOGIES INC.
    Inventors: Tim Fat Tam, Blaise N'Zemba, Regis Leung-Tuong, Yingsheng Wang, Yanqing Zhao, Lily Yu
  • CRYSTALLINE FORMS OF THE MONO-SODIUM SALT OF D-ISOGLUTAMYL-D-TRYPTOPHAN
    Publication number: 20100029742
    Abstract: The present invention relates to crystalline forms of the mono-sodium salt of D-isoglutamyl-D-tryptophan, pharmaceutical compositions comprising them, their use in the treatment of various diseases and conditions, and processes for their preparation. In particular, the present invention relates the crystal modification 1 (polymorphic form F), the crystal modification 2 (polymorphic form I), and the crystal modification 3 (polymorphic form X) of the mono-sodium salt of D-isoglutamyl-D-tryptophan.
    Type: Application
    Filed: February 11, 2008
    Publication date: February 4, 2010
    Applicant: Apotex Technologies Inc.
    Inventors: Tim Fat Tam, Blaise N'Zemba, Regis Leung-Tuong, Yingsheng Wang, Yanqing Zhao, Lily Yu
  • CRYSTALLINE D-ISOGLUTAMYL-D-TRYPTOPHAN AND THE MONO AMMONIUM SALT OF D-ISOGLUTAMYL-D-TRYPTOPHAN
    Publication number: 20100016243
    Abstract: A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D-tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1:1) is a stable pharmaceutical solid.
    Type: Application
    Filed: November 26, 2007
    Publication date: January 21, 2010
    Applicant: Apotex Technologies Inc.
    Inventors: Tim Fat Tam, Blaise N'Zemba, Regis Leung-Tuong, Yingsheng Wang, Yanqing Zhao, Lily Yu