Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

Abstract: A pill crusher device for crushing one or more pills is described. The device includes a male grinder component and a female grinder component that, together, form an enclosed chamber. The male grinder component is rotatable relative to the female grinder component, thereby enabling sets of serrated edges to move relative to each other and crush the one or more pills into a powder. A spring, valve, and adapter system enables the selective injection of liquid, the filtered passing of air, and the ability to repeatedly inject and suction out a liquid/powder mixture.

Abstract: The invention provides novel compounds having the general formula I: or pharmaceutically acceptable salts thereof, wherein RA, RB1, RB2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

Abstract: The invention provides novel compounds having the general formula I: wherein R1, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

Abstract: The invention provides novel compounds having the general formula I: wherein R1, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

Abstract: Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

Abstract: A computer implemented method and a mobile stamp creation and communication system (MSCCS) dynamically creates, renders, and transforms a digital stamp for a stamped communication and media interactions. The MSCCS creates digital stamps by integrating media content, data elements, and dynamic functional elements received from multiple sources. The MSCCS renders the digital stamps to a user device for user selection based on dynamic rendering criteria, generates a stamped communication with the selected digital stamps, and marks the selected digital stamps with a visual usage marker that indicates use of the selected digital stamps in the stamped communication. The MSCCS transforms the marked digital stamps into dynamic content on the user device using data elements and functional elements imbedded in the marked digital stamps and inherent elements of the user device for performing actions on the marked digital stamps and invoking media interactions for creation and rendering of enhanced digital stamps.

Abstract: Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

Abstract: The invention provides novel compounds having the general formula I: wherein R1, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

Abstract: Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

Abstract: A computer implemented method and a personal communication system (PCS) for generating and delivering a personalized communication based on a time condition. The PCS configures a preliminary time condition and determines an optimal time condition from the preliminary time condition, a sender configured time condition, and a recipient configured time condition. The PCS detects a sender's attempt to generate and send the personalized communication based on media content received from a sender device. The PCS times the composition of the personalized communication, generates a timing verification report that verifies whether the optimal time condition is met, and performs an action based on the verification. The action includes rendering a notification to the sender device for instructing the sender to continue composing the personalized communication until the optimal time condition is met, or generating and delivering the personalized communication to recipient devices when the optimal time condition is met.

Abstract: Tip-grouting tools may include at least one inlet, an outlet in communication with the at least one inlet, and a distribution material defining a tortuous path between the at least one inlet and the outlet. The distribution material may be configured to distribute at least one of pressure, mass, and flow of grouting material across the outlet.

Abstract: Tip-grouting tools may include at least one inlet, an outlet in communication with the at least one inlet, and a distribution material defining a tortuous path between the at least one inlet and the outlet. The distribution material may be configured to distribute at least one of pressure, mass, and flow of grouting material across the outlet.

Abstract: A computer implemented method and a mobile stamp creation and communication system (MSCCS) dynamically creates, renders, and transforms a digital stamp for a stamped communication and media interactions. The MSCCS creates digital stamps by integrating media content, data elements, and dynamic functional elements received from multiple sources. The MSCCS renders the digital stamps to a user device for user selection based on dynamic rendering criteria, generates a stamped communication with the selected digital stamps, and marks the selected digital stamps with a visual usage marker that indicates use of the selected digital stamps in the stamped communication. The MSCCS transforms the marked digital stamps into dynamic content on the user device using data elements and functional elements imbedded in the marked digital stamps and inherent elements of the user device for performing actions on the marked digital stamps and invoking media interactions for creation and rendering of enhanced digital stamps.

Abstract: A computer implemented method and a personal communication system (PCS) for generating and delivering a personalized communication based on a time condition are provided. The PCS configures a preliminary time condition and determines an optimal time condition from the preliminary time condition, a sender configured time condition, and a recipient configured time condition. The PCS detects a sender's attempt to generate and send the personalized communication based on media content received from a sender device. The PCS times the composition of the personalized communication, generates a timing verification report that verifies whether the optimal time condition is met, and performs an action based on the verification.