Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A positive displacement compressor includes a positive displacement compressor rotor; a shaft operative to support the positive displacement compressor rotor; a bearing operative to support the shaft; a first structure having a first squeeze film compression surface; and a second structure having a second squeeze film compression surface spaced apart radially from the first squeeze film compression surface. The first and second structures are constructed to jointly form a squeeze film damper using the first and second squeeze film compression surfaces. The squeeze film damper is operative to provide squeeze film damping of vibrations. An annular oil discharge groove is disposed adjacent to a first end of the squeeze film damper. A first o-ring gland houses a circumferential-sealing o-ring disposed proximate to the first end of the squeeze film damper. A second o-ring gland houses a second circumferential-sealing o-ring disposed proximate to a second end of the squeeze film damper.

Abstract: A positive displacement compressor includes a positive displacement compressor rotor; a shaft operative to support the positive displacement compressor rotor; a bearing operative to support the shaft; a first structure having a first squeeze film compression surface; and a second structure having a second squeeze film compression surface spaced apart radially from the first squeeze film compression surface. The first and second structures are constructed to jointly form a squeeze film damper using the first and second squeeze film compression surfaces. The squeeze film damper is operative to provide squeeze film damping of vibrations. An annular oil discharge groove is disposed adjacent to a first end of the squeeze film damper. A first o-ring gland houses a circumferential-sealing o-ring disposed proximate to the first end of the squeeze film damper. A second o-ring gland houses a second circumferential-sealing o-ring disposed proximate to a second end of the squeeze film damper.

Abstract: The present invention provides a device for storing or securing objects in a truck bed. The device comprises a collapsible compartment and two or more straps, each strap comprising a first end attached to the compartment and a second end having a fastener affixed to the second end for securing the second end to a rigid component of the truck, such as the truck frame. The storage compartment and system secures objects from sliding around the bed and protects the objects from damage during transport or inclement weather. The device may be installed without invasive modification of the truck bed, conserves cargo hauling capacity of the truck by including a compartment that is collapsible, and, optionally, provides tie downs for securing oversized objects in the truck bed.

Abstract: A burn prevention screen for use with an outdoor cooking grill. The burn prevention screen has a piece of high temperature tolerant material and a fastener for securing the high temperature tolerant material to the external surface of the grill. The high temperature tolerant material should be flexible, weather resistant, have a low thermal conductivity and be stable at temperatures in excess of 450° F. to 800° F. for extended periods of time. Examples of suitable material include felts, woven ceramic fiber, polymer sheet, composite fabric, other similar materials, or combinations of these materials. The fasteners are preferably magnets, with the preferred magnet being a rare earth magnet or other high temperature tolerant magnet that will retain its magnetic performance after repeated heating and cooling cycles.

Abstract: The present invention provides a device for storing or securing objects in a truck bed. The device comprises a collapsible compartment and two or more straps, each strap comprising a first end attached to the compartment and a second end having a fastener affixed to the second end for securing the second end to a rigid component of the truck, such as the truck frame. The storage compartment and system secures objects from sliding around the bed and protects the objects from damage during transport or inclement weather. The device may be installed without invasive modification of the truck bed, conserves cargo hauling capacity of the truck by including a compartment that is collapsible, and, optionally, provides tie downs for securing oversized objects in the truck bed.