Patents by Inventor Blake Paterson

Blake Paterson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210154260
    Abstract: Enteric compositions comprising one or more tight junction agonists and/or one or more tight junction antagonists are provided. Compositions of the invention may comprise a delayed-release coating disposed over a tight junction agonist and/or tight junction antagonist layer which may be disposed over an inert core. Delayed-release coatings may be substantially stable in gastric fluid and substantially unstable in intestinal fluid, thus providing for substantial release of the tight junction agonist and/or antagonist from the composition in the duodenum or jejunum of the small intestine.
    Type: Application
    Filed: February 1, 2021
    Publication date: May 27, 2021
    Inventors: Blake Paterson, Mark J. Ginski
  • Patent number: 10723763
    Abstract: The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: July 28, 2020
    Assignees: ALBA THERAPEUTICS CORPORATION, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Blake Paterson, Peter Ward, Alessio Fasano
  • Publication number: 20160375089
    Abstract: The present invention provides materials and methods for the treatment of celiac disease. In addition, the present invention provides materials and methods of monitoring the treatment of a subject having celiac disease.
    Type: Application
    Filed: January 26, 2016
    Publication date: December 29, 2016
    Inventors: Alessio Fasano, Blake Paterson
  • Publication number: 20160354426
    Abstract: The present invention provides materials and methods to diagnose asthma. In some embodiments, the present invention provides a method of diagnosing asthma by measuring the zonulin level of a subject. The present invention also provides methods and compositions for treating asthma that comprise one or more zonulin antagonist.
    Type: Application
    Filed: August 12, 2016
    Publication date: December 8, 2016
    Inventor: Blake Paterson
  • Publication number: 20160355551
    Abstract: The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof.
    Type: Application
    Filed: August 12, 2016
    Publication date: December 8, 2016
    Inventors: Blake Paterson, Peter Ward, Alessio Fasano
  • Publication number: 20160349257
    Abstract: The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The methods involve determining the presence, absence, or level of zonulin in a subject sample. In certain embodiments, the need for more laborious and/or invasive tests to monitor disease state is minimized or obviated.
    Type: Application
    Filed: August 12, 2016
    Publication date: December 1, 2016
    Inventors: Julio Bai, Alessio Fasano, Blake Paterson, Alicia Sambueli
  • Publication number: 20160151449
    Abstract: The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
    Type: Application
    Filed: February 3, 2016
    Publication date: June 2, 2016
    Inventors: Blake Paterson, Amir Tamiz, Niranjan Pandey
  • Publication number: 20160109444
    Abstract: The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The methods involve determining the presence, absence, or level of zonulin in a subject sample. In certain embodiments, the need for more laborious and/or invasive tests to monitor disease state is minimized or obviated.
    Type: Application
    Filed: December 18, 2015
    Publication date: April 21, 2016
    Inventors: Julio Bai, Alessio Fasano, Blake Paterson, Alicia Sambueli
  • Publication number: 20160106803
    Abstract: The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof.
    Type: Application
    Filed: December 16, 2015
    Publication date: April 21, 2016
    Inventors: Blake Paterson, Peter Ward, Alessio Fasano
  • Publication number: 20160106802
    Abstract: The present invention provides materials and methods to diagnose asthma. In some embodiments, the present invention provides a method of diagnosing asthma by measuring the zonulin level of a subject. The present invention also provides methods and compositions for treating asthma that comprise one or more zonulin antagonist.
    Type: Application
    Filed: December 16, 2015
    Publication date: April 21, 2016
    Inventor: Blake Paterson
  • Patent number: 9279807
    Abstract: The present invention provides materials and methods for the treatment of celiac disease. In addition, the present invention provides materials and methods of monitoring the treatment of a subject having celiac disease.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: March 8, 2016
    Assignees: ALBA THERAPEUTICS CORPORATION, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Alessio Fasano, Blake Paterson
  • Patent number: 9265811
    Abstract: Enteric compositions comprising one or more tight junction agonists and/or one or more tight junction antagonists are provided. Compositions of the invention may comprise a delayed-release coating disposed over a tight junction agonist and/or tight junction antagonist layer which may be disposed over an inert core. Delayed-release coatings may be substantially stable in gastric fluid and substantially unstable in intestinal fluid, thus providing for substantial release of the tight junction agonist and/or antagonist from the composition in the duodenum or jejunum of the small intestine.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: February 23, 2016
    Assignee: ALBA THERAPEUTICS CORPORATION
    Inventors: Blake Paterson, Mark J. Ginski
  • Patent number: 9241969
    Abstract: Enteric compositions comprising one or more tight junction agonists and/or one or more tight junction antagonists are provided. Compositions of the invention may comprise a delayed-release coating disposed over a tight junction agonist and/or tight junction antagonist layer which may be disposed over an inert core. Delayed-release coatings may be substantially stable in gastric fluid and substantially unstable in intestinal fluid, thus providing for substantial release of the tight junction agonist and/or antagonist from the composition in the duodenum or jejunum of the small intestine.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: January 26, 2016
    Assignee: Alba Therapeutics Corp.
    Inventors: Blake Paterson, Mark J. Ginski
  • Publication number: 20150164978
    Abstract: Enteric compositions comprising one or more tight junction agonists and/or one or more tight junction antagonists are provided. Compositions of the invention may comprise a delayed-release coating disposed over a tight junction agonist and/or tight junction antagonist layer which may be disposed over an inert core. Delayed-release coatings may be substantially stable in gastric fluid and substantially unstable in intestinal fluid, thus providing for substantial release of the tight junction agonist and/or antagonist from the composition in the duodenum or jejunum of the small intestine.
    Type: Application
    Filed: February 24, 2015
    Publication date: June 18, 2015
    Inventors: Blake Paterson, Mark J. Ginski
  • Publication number: 20140294894
    Abstract: The present invention provides materials and methods to facilitate the transcutaneous delivery of therapeutic agents. In some embodiments, agonists of tight junctions are used in compositions to facilitate the uptake of therapeutic agents from the skin. In a particular embodiment, the present invention provides immunogenic compositions comprising a tight junction agonist and an antigen. In a particular embodiment, the present invention provides vaccine compositions comprising a tight junction agonist and an antigen.
    Type: Application
    Filed: April 2, 2014
    Publication date: October 2, 2014
    Applicant: Alba Therapeutics Corporation
    Inventors: Dorothea Sesardic, Blake Paterson
  • Publication number: 20140296165
    Abstract: The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
    Type: Application
    Filed: June 16, 2014
    Publication date: October 2, 2014
    Inventors: Blake Paterson, Amir Tamiz, Niranjan Pandey
  • Patent number: 8796203
    Abstract: The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: August 5, 2014
    Assignee: Alba Therapeutics Corporation
    Inventors: Blake Paterson, Amir Tamiz, Niranjan Pandey
  • Publication number: 20140200271
    Abstract: Memantine compositions and methods of use are described herein. In some embodiments, the compositions comprise memantine and an absorption enhancer, or memantine and an elimination enhancer, or memantine and an absorption enhancer and an elimination enhancer.
    Type: Application
    Filed: July 2, 2013
    Publication date: July 17, 2014
    Applicant: Cerecor, Inc.
    Inventors: Blake Paterson, Mark Ginski, Brendan Canning
  • Patent number: 8728491
    Abstract: The present invention provides materials and methods to facilitate the transcutaneous delivery of therapeutic agents. In some embodiments, agonists of tight junctions are used in compositions to facilitate the uptake of therapeutic agents from the skin. In a particular embodiment, the present invention provides immunogenic compositions comprising a tight junction agonist and an antigen. In a particular embodiment, the present invention provides vaccine compositions comprising a tight junction agonist and an antigen.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: May 20, 2014
    Assignee: Alba Therapeutics Corporation
    Inventors: Dorothea Sesardic, Blake Paterson
  • Publication number: 20130295594
    Abstract: The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The methods involve determining the presence, absence, or level of zonulin in a subject sample. In certain embodiments, the need for more laborious and/or invasive tests to monitor disease state is minimized or obviated.
    Type: Application
    Filed: May 1, 2012
    Publication date: November 7, 2013
    Applicants: Alba Therapeutics Corporation, University of Maryland, Baltimore
    Inventors: Julio Bai, Alessio Fasano, Blake Paterson, Alicia Sambueli