Abstract: The present invention includes non-invasive methods of treating aging using low frequency structured and modulated ultrasound. The ultrasound irradiation causes mechanical stretching of cells even within the body of an organism which in turn can reverse the characteristics of senescent cells to counteract the effect of senescent cells on the function of the tissues wherein they reside. Senescence reversal by ultrasound involves at least one of: activates cell growth, reduces cell size, increases secretion of growth factors, increases mitochondrial fission and/or promotes wound healing. Ultrasound treatment improves the function of aged individuals, of specific organs, of wound healing and enables the greater expansion of normal cells in vitro. Ultrasound can be delivered in spas for the whole organism or smaller targeted ultrasound devices can be made for specific organs or cell applications.