Abstract: A medical balloon sensing assembly constituted of: a handle; a first catheter extending distally from the handle; an inflatable medical balloon, the inflatable medical balloon secured by the first catheter; at least one sensor position member; and at least one sensor secured to the at least one sensor position member, wherein the at least one sensor position member is arranged to contact an outer face of the inflatable medical balloon.

Abstract: A biomedical sensor is provided that includes a deformable body panel, a first ultrasonic transducer, a second ultrasonic transducer, and a displacement sensor. The first and second ultrasonic transducers are attached to, and the displacement sensor is in communication with, the deformable body panel. The biomedical sensor is disposable in at least one default configuration wherein the first and second ultrasonic transducers are disposed relative to one another in a known first spatial transducer configuration. The biomedical sensor is disposable in one or more deformed configurations wherein the first and second ultrasonic transducers are disposed relative to one another in a second spatial transducer configuration different than the first spatial transducer configuration. The at least one displacement sensor is configured to produce signal information indicative of a difference between the first and second spatial transducer configurations.

Abstract: Disclosed is a system to provide adaptive tuning through a control system to a finger cuff connectable to a patient's finger to be used in measuring the patient's blood pressure in the patient's artery by a blood pressure measurement system utilizing a volume clamp method. When the finger cuff is placed around the patient's finger, the bladder and the LED-PD pair aid in measuring the patient's blood pressure by the blood pressure measurement system utilizing the volume clamp method, wherein the adaptive tuning system: applies a first pressure impulse and measures a pleth versus time response; from the pressure versus time response, determines pleth servo gains that compensate for delays in a pleth response of the finger; and uses the determined pleth servo gains in the control system in measuring the patient's blood pressure by the blood pressure measurement system utilizing the volume clamp method.

Abstract: Modular microfluidic channel structures for conducting liquid from a reservoir include a sensor for monitoring a parameter (such as flow rate or pressure) relating to liquid flowing therethrough. The microfluidic channel generally comprises a thermally insulating substrate made of one or more materials such as, e.g., glass, fused silica, parylene, and/or silicone.

Abstract: Disclosed is a system to provide adaptive tuning through a control system to a finger cuff connectable to a patient's finger to be used in measuring the patient's blood pressure in the patient's artery by a blood pressure measurement system utilizing a volume clamp method. When the finger cuff is placed around the patient's finger, the bladder and the LED-PD pair aid in measuring the patient's blood pressure by the blood pressure measurement system utilizing the volume clamp method, wherein the adaptive tuning system: applies a first pressure impulse and measures a pleth versus time response; from the pressure versus time response, determines pleth servo gains that compensate for delays in a pleth response of the finger; and uses the determined pleth servo gains in the control system in measuring the patient's blood pressure by the blood pressure measurement system utilizing the volume clamp method.

Abstract: Disclosed is a system to monitor a finger cuff connectable to a patient's finger to be used in measuring the patient's blood pressure by a blood pressure measurement system utilizing the volume clamp method and to measure the plethysmogram of the finger cuff. The system comprises the finger cuff that includes an enclosing portion that encloses a patient's finger. The enclosing portion includes a bladder and a light emitting diode (LED) and photodiode (PD) pair. The system further comprises a processor to: command applying pneumatic pressure to the bladder of the finger cuff from a low pressure to a high pressure; measure the plethysmogram of the finger cuff as the pressure increases from the low pressure to the high pressure; and determine fitness of the finger cuff on the patient's finger based on the measured plethysmogram. When the finger cuff is placed around the patient's finger, the bladder and the LED-PD pair aid the processor in measuring the plethysmogram.

Abstract: Disclosed is a blood pressure measurement device for a patient at a patient measurement site, comprising: a housing; and a pressure sensing chip mounted in the housing that is attachable to the patient measurement site. The pressure sensing chip may include a pressure transducing member. The pressure sensing chip may be configured to measure the patient's blood pressure based upon: 1) pressure applied by the patient's blood against the pressure transducing member at a first side of the pressure transducing member; and 2) gravity generated pressures over a height difference between the patient's heart level and a point of blood pressure measurement applied against the pressure transducing member at a second side of the pressure transducing member.

Abstract: Disclosed is a finger cuff that may comprise an expandable coil and a bladder. The expandable coil has a finger cavity that includes an LED-PD pair and that is generally smaller than a patient's finger. The expandable coil may include a semi-rigid substrate that is expandable, such that, when the finger cavity of the expandable coil is placed around the patient's finger, the finger cavity and expandable coil expand to surround the patient's finger while the expandable coil provides an approximately constant force to the patient's finger. The bladder is mounted within the finger cavity, such that, when the patient's finger is received and surrounded in the finger cavity of the expandable coil, the patient's finger abuts against the bladder mounted within the finger cavity so that the bladder and the LED-PD pair may be used in measuring the patient's blood pressure by a blood pressure measurement system.

Abstract: Disclosed is a connector for a blood pressure measurement system that includes a pressure generating and regulating system and a finger cuff, in which the connector comprises: a first half portion pneumatically and electrically connected to the pressure generating and regulating system; and a second half portion fixedly attached to the finger cuff, wherein the first half portion and the second half portion are connectable in two or more orientations, and wherein the pressure generating and regulating system and the finger cuff are pneumatically and electrically connected when the first half portion and the second half portion are connected.

Abstract: Disclosed is a blood pressure measurement device that utilizing volume clamping and that is wearable by a patient. The blood pressure measurement device may comprise: a finger cuff attachable to the patient's finger including a light emitting diode (LED)-photodiode (PD) pair to measure a pleth signal and a bladder surrounding the finger and a blood pressure measurement controller coupled to the bladder through a finger cuff connector to provide pneumatic pressure to the bladder. The blood pressure measurement controller may be wearable by the patient. The blood pressure measurement controller may include: a pump coupled to the finger cuff connector, a valve, a pressure sensor, and control circuitry coupled to the pump, the valve, the pressure sensor, and the LED-PD pair.

Abstract: Modular microfluidic channel structures for conducting liquid from a reservoir include a sensor for monitoring a parameter (such as flow rate or pressure) relating to liquid flowing therethrough. The microfluidic channel generally comprises a thermally insulating substrate made of one or more materials such as, e.g., glass, fused silica, parylene, and/or silicone.

Abstract: A method of screening one or more cells is described; the method includes: (i) providing one or more cells to a nanoelectromechanical system (NEMS) force sensor; (ii) applying at least one reagent to the one or more cells; and (iii) observing a response of the one or more cells to the reagent with the force sensor, thereby screening the one or more cells.

Abstract: A method of screening one or more cells is described; the method includes: (i) providing one or more cells to a nanoelectromechanical system (NEMS) force sensor; (ii) applying at least one reagent to the one or more cells; and (iii) observing a response of the one or more cells to the reagent with the force sensor, thereby screening the one or more cells.

Abstract: A MEMS system, such as a biosensor, includes a micromechanical resonator and a piezoresistive sensing element which includes an organic semiconductor, such as an organic thin film transistor.