Abstract: Embodiments of the invention include a method of collecting and reporting quality of life data from a patient. A patient may participate in a collection of surveys during the course of disease treatment that are automatically tailored to the patient's disease state using multidimensional tools to generate quality of life metrics. Reports are generated from the aggregate data to aid in treatment of the patient by enhancing patient/healthcare provider communications, patient education and by giving the healthcare provider reports on quality of life metrics correlated to the prescribed treatments, comorbid diseases, disease specific and medication specific review of systems and patient compliance with the prescribed treatments. Further, data from multiple patients are aggregated for reports that can provide evaluations of the effect of prescribed treatments, reasons for patient non-compliance with prescribed treatments and the prevalence and effect of off-label use of medications.