Patents by Inventor Blas Frangione

Blas Frangione has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid beta for induction of an immune response to amyloid beta and amyloid deposits
    Publication number: 20020077288
    Abstract: The present invention relates to synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid &bgr; which can be used alone or conjugated to an immunostimulatory molecule in an immunizing composition for inducing an immune response to amyloid &bgr; peptides and amyloid deposits.
    Type: Application
    Filed: May 22, 2001
    Publication date: June 20, 2002
    Applicant: New York University
    Inventors: Blas Frangione, Thomas Wisniewski, Einar M. Sigurdsson
  • Uses for indole-3-propionic acids and salts and esters thereof
    Patent number: 6395768
    Abstract: The cytotoxic effects of amyloid beta protein on cells are prevented by contacting the cells with an effective amount of an indole-3-propionic acid or a salt or ester thereof. Furthermore, a fibrillogenic disease can be treated in a human subject by administering to the human subject an amount of-an indole-3-propionic acid or a salt or ester thereof effective to prevent or reverse fibrillogenesis. Oxidation in a biological sample can be decreased by contacting the biological sample with an effective amount of an indole-3-propionic acid or a salt or ester thereof. Additionally, diseases or other conditions where free radicals and/or oxidative stress play a role can be treated by administering an effective amount of an indole-3-propionic acid or a salt or ester thereof.
    Type: Grant
    Filed: May 30, 2000
    Date of Patent: May 28, 2002
    Assignees: South Alabama Medical Science Foundation, New York University
    Inventors: Miguel A. Pappolla, Blas Frangione, Jorge Ghiso, Burkhard Poeggeler
  • Method for delaying the onset of alheimer's disease and for treatment or delaying the onset of other amyloidosis-related diseases/disorders
    Patent number: 6274615
    Abstract: The present invention relates to a method of using melatonin to reduce, inhibit or reverse the formation of amyloid fibrils and amyloid or amyloid-like deposits. The present invention also relates to a method for delaying the onset of Alzheimer's Disease or other amyloidosis-related diseases/disorders or for treating such diseases/disorders by administering an effective amount of melatonin to a subject in need thereof.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: August 14, 2001
    Assignees: South Alabama Medical Science Foundation, New York University
    Inventors: Miguel A. Pappolla, Blas Frangione, Jorge Ghiso
  • Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
    Patent number: 5948763
    Abstract: Novel peptides capable of interacting with a hydrophobic structural determinant on a protein or peptide for amyloid or amyloid-like deposit formation inhibit and structurally block the abnormal folding of proteins and peptides into amyloid or amyloid-like deposits. Methods for preventing, treating or detecting disorders or diseases associated with amyloid-like fibril deposits, such as Alzheimer's disease and prion-related encephalopathies, are also provided.
    Type: Grant
    Filed: April 10, 1996
    Date of Patent: September 7, 1999
    Assignee: New York University
    Inventors: Claudio Soto-Jara, Marc H. Baumann, Blas Frangione