Patents by Inventor Blessing Akobundu

Blessing Akobundu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeting enhancer RNAs for the treatment of primary brain tumors
    Patent number: 12060557
    Abstract: The invention provides enhancer RNAs (eRNAs) that are expressed specifically in glioma stem cells and whose expression correlates with decreased survival of patients with glioblastomas. The eRNAs are selected, for example, from eTMEM88b, eRTP5, or eNINJ1. The invention also provides an RNA therapy that targets glioma stem cell eRNAs using synthetic oligonucleotides that knock out the eRNA expression. The invention further provides viral vectors that deliver shRNA that inhibit the expression of the eRNA.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: August 13, 2024
    Assignees: Brown University, Rhode Island Hospital
    Inventors: Nikolaos Tapinos, Blessing Akobundu
  • TARGETING ENHANCER RNAS FOR THE TREATMENT OF PRIMARY BRAIN TUMORS
    Publication number: 20230323349
    Abstract: The invention provides enhancer RNAs (eRNAs) that are expressed specifically in glioma stem cells and whose expression correlates with decreased survival of patients with glioblastomas. The eRNAs are selected, for example, from eTMEM88b, eRTP5, or eNINJ1. The invention also provides an RNA therapy that targets glioma stem cell eRNAs using synthetic oligonucleotides that knock out the eRNA expression. The invention further provides viral vectors that deliver shRNA that inhibit the expression of the eRNA.
    Type: Application
    Filed: September 1, 2021
    Publication date: October 12, 2023
    Inventors: Nikos Tapinos, Blessing Akobundu