Abstract: A surgical upper computer for a total knee arthroplasty, and a total knee arthroplasty system, and in the field of surgical equipment. The surgical upper computer includes a memory storing a first computer program which enables a processor to execute a first operating mode of the surgical upper computer, where the first operating mode includes: exhibiting, by an interactive interface, to a user, first information to be input, the first information including a magnitude range and change interval of a pushing force applied between a femur and a tibia; in response to user input, controlling a butting member and a push plate to apply different pushing forces at a preset joint flexion angle, and acquiring relationship data between the pushing force and a gap; and displaying the relationship data. Accordingly, the force and gap between soft tissues in the total knee arthroplasty can be acquired and displayed.

Abstract: An oral imaging device and an oral imaging system are provided. The oral imaging device includes a body, a support arm coupled to the body, and a camera module positioned at an intra-oral end of the support arm and configured to capture at least a first image including at least a first portion of a first dental arch. The support arm includes the intra-oral end and a first guide structure. And the support arm is stabilized by the first guide structure when the oral imaging device rests on a second dental arch.

Abstract: An oral imaging device includes an oral camera and a mouth opener. The oral camera includes a main body and a camera module. The camera module includes at least one camera. The mouth opener defines an imaging through hole penetrating through the mouth opener from a first end to a second end thereof. The second end of the mouth opener is configured to abut against an oral cavity structure of a user. The mouth opener is movable relative to the camera module to switch the oral imaging device between a first form and a second form. In the first form, the at least one camera faces the imaging through hole and does not exceed the second end of the mouth opener. In the second form, the at least one camera is exposed outside the imaging through hole and is configured to insert into an oral cavity of the user.

Abstract: The present invention relates to the technical fields of genetic engineering and bioinformatics, in particular, to a method for creating a new gene in an organism in the absence of an artificial DNA template, and a use thereof. The method comprises simultaneously generating DNA breaks at two or more different specific sites in the organism's genome, wherein the specific sites are genomic sites capable of separating different genetic elements or different protein domains, and the DNA breaks are ligated to each other through non-homologous end joining (NHEJ) or homologous repair to generate a new combination of the different gene elements or different protein domains that is different from the original genome sequence, thereby creating a new gene. The new gene of the invention can change the growth, development, resistance, yield and other traits of the organism, and has great value in application.

Abstract: One embodiment of the present invention discloses a remote-controlled toy vehicle with omnidirectional adjustable steering, comprising: a vehicle body having a remote control receiving circuit; a remote control device capable of communicating with the remote control receiving circuit; at least one steering means mounted on the vehicle body; and a plurality of wheels; wherein each steering means comprises a steering drive means, a pivot rod, a connecting rod, at least one swivelable member, and at least one wheel bracket, with the number of swivelable members. The present remote-controlled toy vehicle with omnidirectional adjustable steering can steer at various angles, enabling flexible control over its driving direction, while having a simple structure and offering convenient control and adjustment operations.

Abstract: The present disclosure relates to a fused ring compound, a conjugate thereof and the use thereof. The compound and the conjugate of the present disclosure have good activity of inhibiting tumor cells, stability, and in vivo drug efficacy in animals.

Abstract: A strong PUF circuit with good stability and anti-ML attack capacity is provided. The strong PUF circuit includes n delay modules, n?1 interconnection modules, an arbiter array and an XOR gate, wherein n is an integer greater than or equal to 1, each delay module is implemented based on a bias source structure, and the number of transmission paths of input signals can be increased by means of the characteristics of the bias source structure of the delay module to realize a diversity of transmission, thus realizing a highly complex and unpredictable challenge-response mapping relation without multiple strong PUFs. The transmission characteristics (transmission paths) of the input signals can be further obfuscated by means of the interconnection modules. Only one XOR gate is used for generating response outputs to further improve the stability.

Abstract: A semiconductor package comprises a lead frame, a first high-voltage field-effect transistor (FET), a source clip, a gate clip, a second high-voltage FET, a drain clip or a bond wire, and a molding encapsulation. A method comprises the steps of providing a lead frame; mounting a first high-voltage FET; attaching a source clip and a gate clip; mounting a second high-voltage FET; attaching a drain clip or a bond wire, forming a molding encapsulation; and applying a singulation process.

Abstract: A method for the preparation of high-purity cristobalite is provided. The method involves obtaining high-purity cristobalite by drying, calcining, and dispersing amorphous silica. In comparison with existing technologies, the beneficial effects of the present invention are as follows: 1. Amorphous silica has a large specific surface area and is rich in hydroxyl groups. Therefore, the cristobalite transformed from amorphous silica is prone to have pores. To eliminate these pores, the present invention employs a coupling agent for surface treatment followed by calcination. 2. The inventor chooses the silane coupling agent with a short chain length under the same mass, reducing the pores in cristobalite. Moreover, there is a certain reduction in calcination temperature and time. The possible reason is that the silane coupling agent decomposes at high temperatures, forming silica.

Abstract: The disclosure relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, and Y are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds of Formula (I) may modulate the activity of antigens of interest and may be useful in inducing or enhancing an immune response against diseases, disorders and conditions mediated by antigens of interest. In a particular embodiment, the compounds of Formula (I) may be useful as a component of a liposomal adjuvant formulation.

Abstract: The present invention relates to the field of biotechnology, and specifically relates to a PPO polypeptide tolerant to PPO-inhibiting herbicides and use thereof. The said polypeptide contains the motif “LLLNYI”, wherein leucine L at position 3 in the said motif is substituted with any other amino acid, or tyrosine Y at position 5 is substituted with any other amino acid. It can be used in plants, including commercial crops, to greatly improve plant resistance to PPO-inhibiting herbicides according to the herbicide resistance characteristics and herbicide selectivity, so as to control weed growth economically.

Abstract: Disclosed is a harmonic suppression circuit for tunneling magnetoresistance sensors, which restrains even-order harmonic distortion by means of a fully differential interface circuit topological structure, restrains the charge injection and clock feedthrough effect of transistors by means of a virtual geminate transistor parallel structure and reduces the on resistance by means of a complementary switch structure to effectively restrain harmonic distortion. The harmonic suppression circuit for tunneling magnetoresistance sensors has a high linearity and has a high reading accuracy when used for reading sensing data of tunneling magnetoresistance sensors.

Abstract: Provided is an antibody that recognizes a tight junction protein 18.2, a preparation method therefor, and a use thereof.

Abstract: The present invention discloses an omnidirectional adjustable steering mechanism of a remote-controlled toy vehicle, comprising: a plurality of steering means, each steering means comprising a steering drive means, a pivot rod, a connecting rod, at least one swivelable member, and at least one wheel bracket, with the number of swivelable members and the number of wheel brackets being equal; wherein in each steering means, the pivot rod is connected at a first end to a power output end of the steering drive means and hinged at a second end to a middle of the connecting rod, each swivelable member is swivelably mounted on a vehicle body of the remote-controlled toy vehicle. The omnidirectional adjustable steering mechanism can steer at various angles, enabling flexible control over the vehicle's driving direction, while having a simple structure and offering convenient control and adjustment operations.

Abstract: Provided are a bispecific antibody or an antigen-binding fragment thereof, a nucleic acid encoding the same, a cell comprising the nucleic acid, a composition comprising the bispecific antibody or antigen-binding fragment thereof, the nucleic acid and/or the cell, and related applications of the bispecific antibody or antigen-binding fragment thereof in the treatment of cancer.

Abstract: A bistable weak PUF circuit with an autonomous stability screening function is provided. The bistable weak PUF circuit includes a decoder, a timing circuit, and a PUF core circuit is provided. The PUF core circuit realizes stable bit screening by connecting two screening levels. When the two screening levels connected to the PUF core circuit are equal, the PUF core circuit generates a W-bit original PUF response in one clock cycle under the control of an m-bit word line level signal output thereto by the decoder. Then, the m-bit word line level signal received by the PUF core circuit is kept unchanged, one of the two screening levels connected to the PUF core circuit is kept unchanged, and the other is reduced by a certain amplitude, and two W-bit screened PUF responses are obtained after the screening levels are exchanged.

Abstract: Aspects relate to carrier aggregation. Selection of an uplink component carrier for carrier aggregation may be flexible in the sense that the frequency band of the uplink component carrier need not be one of the frequency bands allocated for the downlink component carriers. Thus, in some aspects, an uplink component carrier may be decoupled from (e.g., independent of) the downlink carriers. A decision of whether to implement flexible uplink component carrier selection may be based on network traffic (e.g., particular traffic use cases). As one example, the data throughput requirement for downlink traffic may be relatively high, but the component carriers selected for the downlink traffic to provide this throughput might not provide a desired level of service for the uplink traffic. Thus, one or more component carrier bands selected for the uplink traffic may be different from any of the component carrier bands selected for the downlink traffic.

Abstract: A wireless communication in a user device includes configuring a plurality of transmission chains with a plurality of carriers; and uploading data in a time-division duplexed (TDD) or frequency division duplex (FDD) transmission through the plurality of transmission chains. In some embodiments, two transmission chains and two carriers are used for carrier aggregation uplink of data. An apparatus may include a plurality of transmit chains, each of the plurality of transmit chains providing transmission of data using TDD or FDD transmissions; a plurality of antennas, each of the antennas providing transmission of data from one of the plurality of transmit chains into one of a plurality of carriers; and a time-division multiplexed (TDM) switch coupled between the plurality of transmit chains and the plurality of antennas such that each of the plurality of transmit chains transmits data on one of the plurality of carriers.

Abstract: Provided are a bispecific antibody or an antigen-binding fragment thereof, a nucleic acid encoding the same, a cell comprising the nucleic acid, a composition comprising the bispecific antibody or antigen-binding fragment thereof, the nucleic acid and/or the cell, and related applications of the bispecific antibody or antigen-binding fragment thereof in the treatment of cancer.