Patents by Inventor Bo-Fong Chen

Bo-Fong Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparation of optically pure -substituted-3-methoxypropionic acid derivatives
    Patent number: 9718765
    Abstract: A method of producing optically pure N-substituted-3-methoxy propionic acid is provided, which includes the steps of: reacting N-substituted-3-methoxy propionic acid represented by formula (III): with a chiral amine in a solvent to obtain a diastereomeric salt represented by formula (IV): subjecting the diastereomeric salt to a sequential washing process to obtain the optically pure N-substituted-3-methoxy propionic acid represented by one of formulae (Ia) and (Ib): wherein R1 is selected from the group consisting of C1-5 alkyl, C1-6 alkoxy and C6-10 aryloxy group, and R2 is selected from the group consisting of C2-5 alkyl, C6-8 cycloalkyl and C6-10 aryl.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: August 1, 2017
    Assignee: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Yen-Chi Su, Yen-Wei Li, Feng-Hsu Li, Chen-Wei Huang
  • Preparation of Duloxetine® hydrochloride using optically active methylhydroxylaminopropanol compound as an intermediate
    Patent number: 8957227
    Abstract: The present invention provides a process for preparing duloxetine hydrochloride with higher yield and lower cost.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: February 17, 2015
    Assignee: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Feng-Ju Lu, Jinun-Ban Yeh, Wei-Chyun Wong, Feng-hsu Li, Yen-Wei Li, Yeh-Chi Su
  • PREPARATION OF DULOXETINE HYDROCHLORIDE USING OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL COMPOUND AS AN INTERMEDIATE
    Publication number: 20140005414
    Abstract: The present invention provides a process for preparing duloxetine hydrochloride with higher yield and lower cost.
    Type: Application
    Filed: August 29, 2013
    Publication date: January 2, 2014
    Applicant: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Feng-Ju Lu, Jinun-Ban Yeh, Wei-Chyun Wong, Feng-hsu Li, Yen-Wei Li, Yeh-Chi Su
  • Process for preparing -methyl--hydroxyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine derivative
    Patent number: 8614336
    Abstract: The present invention provides a process for preparing a N-methyl-N-hydroxyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine compound. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and low treatment cost, which includes the preparation of the N-methyl-N-hydroxyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine compound.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: December 24, 2013
    Assignee: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Wei-Chyun Wong
  • Process for preparing ()-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine by using optically active methylhydroxylaminopropanol compound as intermediate
    Patent number: 8530674
    Abstract: The present invention provides (S)-methylhydroxylaminopropanol compound as an intermediate in preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and lower cost by using the (S)-methylhydroxylaminopropanol compound as an intermediate.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: September 10, 2013
    Assignee: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Feng-Ju Lu, Jinun-Ban Yeh, Wei-chyun Wong
  • Optically active methylhydroxylaminopropanol derivative and its use as intermediate for preparation of ()-(-)-3-methylamino-1-(-2-thienyl)propan-1-ol
    Patent number: 8420832
    Abstract: The present invention provides an (S)-methylhydroxylaminopropanol compound and the (S)-methylhydroxylaminopropanol compound of the present invention is used as an intermediate for preparation of (S)-(?)-3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing (S)-(+3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol compound is used as an intermediate.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: April 16, 2013
    Assignee: Sci Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Weichyun Wong
  • Method for preparing atomoxetine
    Patent number: 8299305
    Abstract: The present invention provides an efficient method for preparing atomoxetine in high yield. (R)-methylhydroxylaminopropanol compound of formula (II) in the present invention is used as an intermediate without the need for resolution processes.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: October 30, 2012
    Assignee: Sci Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Yan-Wei Li, Jinun-Ban Yeh, Wei-Chyun Wong
  • OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(-2-THIENYL)PROPAN-1-OL
    Publication number: 20120190869
    Abstract: The present invention provides an (S)-methylhydroxylaminopropanol compound and the (S)-methylhydroxylaminopropanol compound of the present invention is used as an intermediate for preparation of (S)-(?)-3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing (S)-(+3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol compound is used as an intermediate.
    Type: Application
    Filed: March 30, 2012
    Publication date: July 26, 2012
    Applicant: SCI PHARMTECH, INC.
    Inventors: Bo-Fong CHEN, Jinun-Ban YEH, Weichyun WONG
  • Optically active methylhydroxylaminopropanol compound and its use as intermediate for preparation of ()-(?)-3-methylamino-1-(2-thienyl)propan-1-ol
    Patent number: 8168805
    Abstract: The present invention provides an (S)-methylhydroxylaminopropanol derivative and the (S)-methylhydroxylaminopropanol derivative of the present invention is used as an intermediate for preparation of (S)-(?)-3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing (S)-(?)-3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol derivative is used as an intermediate.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: May 1, 2012
    Assignee: SCI Pharmtech, Inc
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Weichyun Wong
  • Preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl) propylamine using optically active methylhydroxylaminopropanol compound as an intermediate
    Patent number: 8148549
    Abstract: The present invention provides a (S)-methylhydroxylaminopropanol derivative as an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol derivative is used as an intermediate.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: April 3, 2012
    Assignee: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Wei-Chyun Wong
  • METHOD FOR PREPARING ATOMOXETINE
    Publication number: 20110319664
    Abstract: The present invention provides an efficient method for preparing atomoxetine in high yield. (R)-methylhydroxylaminopropanol compound of formula (II) in the present invention is used as an intermediate without the need for resolution processes.
    Type: Application
    Filed: June 29, 2010
    Publication date: December 29, 2011
    Inventors: Bo-Fong Chen, Yan-Wei Li, Jinun-Ban Yeh, Wei-Chyun Wong
  • PROCESS FOR PREPARING (S)-(+)-N-METHYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL)PROPYLAMINE BY USING OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL COMPOUND AS INTERMEDIATE
    Publication number: 20110275835
    Abstract: The present invention provides (S)-methylhydroxylaminopropanol compound as an intermediate in preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and lower cost by using the (S)-methylhydroxylaminopropanol compound as an intermediate.
    Type: Application
    Filed: May 6, 2010
    Publication date: November 10, 2011
    Inventors: Bo-Fong Chen, Feng-Ju Lu, Jinun-Ban Yeh, Wei-chyun Wong
  • Methylhydroxylaminopropanol derivative and its use as intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-OL
    Patent number: 7829731
    Abstract: The present invention provides a methylhydroxylaminopropanol derivative and the methylhydroxylaminopropanol derivative of the present invention is used as an intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (+)-(S)—N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing 3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the methylhydroxylaminopropanol derivative is used as an intermediate.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: November 9, 2010
    Assignee: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Weichyun Wong
  • PREPARATION OF (S)-(+)-N-METHYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL) PROPYLAMINE USING OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AS AN INTERMEDIATE
    Publication number: 20100234619
    Abstract: The present invention provides a (S)-methylhydroxylaminopropanol derivative as an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol derivative is used as an intermediate.
    Type: Application
    Filed: March 12, 2009
    Publication date: September 16, 2010
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Wei-Chyun Wong
  • PROCESS FOR PREPARING N-METHYL-N-HYDROXYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL)PROPYLAMINE DERIVATIVE
    Publication number: 20100234620
    Abstract: The present invention provides a process for preparing a N-methyl-N-hydroxyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine compound. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and low treatment cost, which includes the preparation of the N-methyl-N-hydroxyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine compound.
    Type: Application
    Filed: March 5, 2010
    Publication date: September 16, 2010
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Wei-Chyun Wong
  • METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF 3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL
    Publication number: 20090112000
    Abstract: The present invention provides a methylhydroxylaminopropanol derivative and the methylhydroxylaminopropanol derivative of the present invention is used as an intermediate for preparation of 3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (+)-(S)—N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing 3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the methylhydroxylaminopropanol derivative is used as an intermediate.
    Type: Application
    Filed: October 29, 2007
    Publication date: April 30, 2009
    Applicant: SCI Pharmtech, Inc.
    Inventors: Bo-Fong Chen, Jinun-Ban Yeh, Weichyun Wong
  • OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL
    Publication number: 20090112001
    Abstract: The present invention provides an (S)-methylhydroxylaminopropanol derivative and the (S)-methylhydroxylaminopropanol derivative of the present invention is used as an intermediate for preparation of (S)-(?)-3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing (S)-(?)-3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol derivative is used as an intermediate.
    Type: Application
    Filed: May 15, 2008
    Publication date: April 30, 2009
    Applicant: SCI Pharmtech, Inc.
    Inventors: Bo-Fong CHEN, Jinun-Ban YEH, Weichyun WONG