Abstract: The present invention pertains to a pharmaceutical composition for preventing or treating squamous cell carcinoma, the pharmaceutical composition containing a highly expressed lncRNAs in esophageal squamous cell carcinoma (HERES) expression inhibitor. More specifically, the present invention pertains to a pharmaceutical composition which uses a HERES expression inhibitor to reduce the expression of HERES and affect Wnt signaling pathways, and thereby prevent or treat squamous cell carcinoma. The present inventors discovered that the expression pattern of HERES is related to the onset of squamous cell carcinoma, and found that HERES can be a target for treating squamous cell carcinoma.

Abstract: The present invention relates to a squamous cell carcinoma diagnostic or prognosis prediction marker and the use thereof and, more particularly, to the use of a long non-coding RNA as a marker composition for diagnosing or predicting the prognosis of squamous cell carcinoma, a diagnostic composition, diagnostic information-providing method and the like, by means of the correlation between an expression of the long non-coding RNA and squamous cell carcinoma pathogenesis. The inventors discovered that the expression pattern of a long non-coding RNA is related to cancer pathogenesis, investigated the correlation between the expression of a specific long non-coding RNA and squamous cell carcinoma pathogenesis and thus confirmed that the long non-coding RNA can be a squamous cell carcinoma diagnostic or prognosis prediction marker.