Abstract: The invention relates to a pre-filled injection device with a non-removable cartridge wherein the drive mechanics comprises a threaded piston rod which is moved helically in a nut secured to a housing structure. During assembly of the injection device it is possible to rotate the nut member to thereby advance the piston rod into a position eliminating any air-gap otherwise occurring between the piston rod and the plunger inside the cartridge.

Abstract: A flow communication unit (240, 540, 640, 740, 840, 940, 1040, 1140, 1240) for establishing flow communication from a multi-use drug delivery device adapted for extended use, to a flow conducting device, wherein the drug delivery device comprises a reservoir comprising multiple doses of a liquid drug formulation, wherein the reservoir is adapted to pressurize the liquid drug formulation, wherein the flow conducting device (230) is adapted for conducting the drug to the subcutaneous tissue of a subject, wherein the flow communication unit is adapted for being in an unconnected and a connected configuration, whereby the flow communication unit (240, 540, 640, 740, 840, 940, 1040, 1140, 1240) is adapted to enable the extended use of the multi-use drug delivery device.

Abstract: A drug delivery device (100, 300) for delivering a medicament, wherein the device comprises an insertion controlled needle cannula (224, 424), wherein the drug delivery device comprises: a retaining structure (130, 136, 350, 430) axially locked to the housing and adapted for retaining the hub (225, 425) in the proximal position, a pulling structure (230, 320) axially locked to the shield (110, 310) and adapted for being disengaged from the hub (225, 425), in a decouple state, whereby the pulling structure is movable relative to the hub (225, 425), and wherein the pulling structure (230, 320) is further adapted for engaging the hub, in a coupled state, whereby the pulling structure is movable together with the hub, wherein the retaining structure and the pulling structure are operatively connected to the shield (110, 310) and the needle assembly (220, 420) in the active position.

Abstract: A drug delivery device (100, 300) for delivering a plurality of doses of a medicament, wherein a needle shield (110, 310) is operationally coupled to a hub driving structure (210, 430), a active needle assembly (220, 420), a pulling structure (230, 320) and a support structure (136, 336, 338, 350) such that the operation of the needle shield is adapted to drive the active needle assembly (220, 420) to the proximal position of the active needle assembly (220, 420), before the needle shield (110, 310) can reach the proximal position of the needle shield (220, 420), whereby fluid connection can be establish before the drive mechanism can be activated.

Abstract: 1. A drug delivery device for delivering a plurality of fixed doses of a medicament, wherein the drug delivery device comprises a needle magazine with a plurality of needle assemblies, a needle positioning mechanism, a drive mechanism for delivering a fixed dose of the plurality of fixed doses, in response to activation, an activation mechanism for activating the drive mechanism comprising a movable shield (110, 310), wherein the shield (110, 310) is adapted to activate the drive mechanism, in response moving the shield to the proximal position. The drug delivery device further comprises a drop lock mechanism comprising a non-blocking state and a blocking state.

Abstract: A drug delivery device (100, 300) for delivering a plurality of fixed doses, comprising a drive mechanism with a prestrained drive spring (108) for sequentially expelling the plurality of fixed doses, and an activation mechanism comprising an axially movable activation assembly (110, 310) for activating the drive mechanism to expel a fixed dose, and user operable for activation as a first user operation. The device further comprises a double dose prevention mechanism adapted to shift from a non-blocking to a blocking state after the first user operation of activating the activation mechanism, and adapted to shift from the blocking to the nonblocking state, in response to the second user operation of operating the unlocking structure.

Abstract: A drug delivery device (100, 300), comprising a rotatable drum (210, 410) with a plurality of needle assemblies, a shield (110, 410) and a needle change mechanism (134, 233, 105.2, 231, 105.2, 214, 305.1, 317). The needle change mechanism is operationally coupled to the drum (210, 410) and the shield (110, 310). The needle change mechanism is having an active state adapted to induce rotation of the drum (210, 410), in response to a movement of the shield (110, 310), the needle change mechanism further comprises a passive state wherein no rotation is induced on the drum (210, 410). The needle change mechanism is, in response to the second movement of the shield (110, 310), adapted to change from the passive state to the active state after the hollow needle (224, 424) disconnects from the cartridge, whereby it is prevented that the drum (210, 410) rotates while the hollow needle (224, 424) is connected with the cartridge.

Abstract: The invention relates to an injection device for ejecting a predetermined plurality of fixed doses. The doses are expelled by moving a needle shield (30) in the proximal direction which releases a pre-strained torsion spring (115) to eject one of the predetermined doses at the time. The injection device is further provided with a number of integrated needle assemblies (70) which one at the time are brought to an injection position. The needle change mechanism (80,90) operating the needle assemblies is controlled by rotation of the needle shield which is rotatable between a locked and an unlocked position.

Abstract: A drug delivery device (100, 200) for delivering a fixed dose, comprising a drive mecha-nism comprising a drive spring (108, 208), and an activation mechanism comprising a connector (170, 270) adapted for activating the drive mechanism, wherein the drug de-livery device further comprises a split-dose-prevention mechanism adapted for limiting the axial movement of the connector during dosing. The split dose prevention mechanism comprises: (i) a split-dose-prevention structure (184, 284.1, 284.2) provided on the drive tube (180, 280) and extending in a circumferential direction, and (ii) a retention portion (178.3, 278.2) provided on the connector. For the drive tube being arranged in the intermediate position, the split-dose-prevention structure (184, 284.1, 284.2) and the retention portion are arranged with a transverse overlap, whereby movement of the connector in the second axial direction is limited by the split-dose prevention structure.

Abstract: The present invention provides a needle unit (10) for use with a pen injection device, wherein the needle unit (10) comprises a needle shield (50) and an axially movable needle hub (25).

Abstract: The invention relates to a pre-filled injection device with a non-removable cartridge embedded in the housing structure and wherein the piston rod drive mechanism comprises a threaded piston rod which is moved helically in a nut secured to the housing structure. During assembly of the injection device it is possible to eliminate the air-gap between the plunger in the cartridge and the piston rod means by moving the nut element for the drive mechanism axially during assembly. In an alternative solution, the piston rod comprises a telescopic element which can slide axially in relation to the piston rod to obtain the zero position.

Abstract: A shield activated drug delivery device for delivering a plurality of fixed doses comprising a housing, a drive mechanism comprising a drive element (180, 280) adapted to rotate and thereby rotate and axially advance a piston rod (109, 209), wherein the drive mechanism is adapted to expel a dose of the plurality of fixed doses, in response to activation. The injection device further comprises an activation mechanism, and a locking-and-resetting mechanism for releasably locking the shield in an activation position, in response to rotating the shield, and for inducing a rotational movement of the shield, in response to the drive element releasing a releasable lock.

Abstract: The invention relates to a pre-filled injection device with a non-removable cartridge wherein the drive mechanics comprises a threaded piston rod which is moved helically in a nut secured to a housing structure.

Abstract: The present invention provides a needle unit (10) for use with a pen injection device, wherein the needle unit (10) comprises a needle shield (50) and an axially movable needle hub (25).

Abstract: The present invention provides a needle unit (10) for use with a pen injection device, wherein the needle unit (10) comprises a needle shield (50) and an axially movable needle hub (25).

Abstract: The present invention provides a needle unit (10, 310, 410, 510) having a proximal space (13, 513) adapted to accommodate a portion of a variable volume reservoir, the needle unit (10, 310, 410, 510) comprising: a needle carrier (15, 315, 415, 515), a needle tube (21, 121, 221, 321, 421, 521) being fixed to the needle carrier (15, 315, 415, 515) and comprising a distal needle end (23, 123, 223, 323, 423, 523) for providing fluid communication to an injection site, a needle shield (50, 350, 450, 550) carrying a sealed chamber (38, 138, 238, 338, 438, 538) for accommodating a distal portion of the needle tube (21, 121, 221, 321, 421, 521), the sealed chamber (38, 138, 238, 338, 438, 538) being sealed distally by a penetrable self-sealing septum (39, 139, 239, 339, 439, 539), and a flow channel (24, 124, 224, 324, 424, 524) for establishing fluid communication between the sealed chamber (38, 138, 238, 338, 438, 538) and the proximal space (13, 513), wherein the needle shield (50, 350, 450, 550) and the needle ca

Abstract: A flow communication unit (240, 540, 640, 740, 840, 940, 1040, 1140, 1240) for establishing flow communication from a multi-use drug delivery device adapted for extended use, to a flow conducting device, wherein the drug delivery device comprises a reservoir comprising multiple doses of a liquid drug formulation, wherein the reservoir is adapted to pressurize the liquid drug formulation, wherein the flow conducting device (230) is adapted for conducting the drug to the subcutaneous tissue of a subject, wherein the flow communication unit is adapted for being in an unconnected and a connected configuration, whereby the flow communication unit (240, 540, 640, 740, 840, 940, 1040, 1140, 1240) is adapted to enable the extended use of the multi-use drug delivery device.

Abstract: A cartridge system for use with a drug delivery device (100?), comprising: —a pre-filled cartridge comprising: a) a cartridge body (210) accommodating a drug, b) a piston (250) slidably disposed in the cartridge body (210) and configured for providing a proximal seal, the piston (250) comprising: b1) a piston first member (260) comprising a first material and forming a distal end, a proximal end and a sealing periphery in contact with the cartridge body (210), wherein the distal end is in contact with the drug and wherein the proximal end of the piston first member (260) includes a proximally facing opening, and b2) a piston second member (270) comprising a material of lower compressibility compared to the first material, the piston second member (270) comprising a sleeve-formed portion arranged in the proximally facing opening of the piston first member (260), wherein the piston second member (270) comprises a proximally facing opening forming a socket; and—a plug unit (280) coupleable or coupled into the so

Abstract: A drug delivery device (1) comprises a housing and an expelling assembly adapted to expel a dose of drug from a cartridge (380). The expelling assembly comprises a drive spring (135) which in an energized state is adapted to drive the expelling assembly, a rotating component (550,650) adapted to rotate relative to an axis of rotation during expelling of a dose of drug, and user actuated release means (191, 190) for releasing the drive spring to thereby expel a dose of drug. The device is provided with a brake element (575, 675) being moveable in a plane generally perpendicular to the axis of rotation, the brake element being adapted to engage the rotating component such that during rotation thereof the brake element is moved back and forth, whereby the brake element provides a braking action on the rotating component.

Abstract: A drug delivery device (1) comprises a housing and an expelling assembly adapted to expel a dose of drug from a cartridge (380). The expelling assembly comprises a drive spring (135) which in an energized state is adapted to drive the expelling assembly, a rotating component (550,650) adapted to rotate relative to an axis of rotation during expelling of a dose of drug, and user actuated release means (191, 190) for releasing the drive spring to thereby expel a dose of drug. The device is provided with a brake element (575, 675) being moveable in a plane generally perpendicular to the axis of rotation, the brake element being adapted to engage the rotating component such that during rotation thereof the brake element is moved back and forth, whereby the brake element provides a braking action on the rotating component.