Abstract: Disclosed herein is a method of eliminating pathogens with an aerosolized composition with polar or charged droplets comprising chlorine dioxide The aerosolized composition is generated from an acidic chlorine dioxide composition comprising at least one charged surfactant.

Abstract: The present invention relates to a model based positioning system that includes a positioning device having at least one transmitter configured to be in a tracking environment, e.g. inserted into a body, a receiver having a plurality of receiver elements arranged outside the tracking environment, a control unit configured to measure amplitude and/or phase information of a signal transmitted from the at least one transmitter and received at each receiving element, and a memory unit for storing a model for each receiving element. The control unit is also configured to estimate the position P of the positioning device by comparing the model for each receiving element with the measured received signal for each receiving element.

Abstract: The present invention relates to a model based positioning system that includes a positioning device having at least one transmitter configured to be in a tracking environment, e.g. inserted into a body, a receiver having a plurality of receiver elements arranged outside the tracking environment, a control unit configured to measure amplitude and/or phase information of a signal transmitted from the at least one transmitter and received at each receiving element, and a memory unit for storing a model for each receiving element. The control unit is also configured to estimate the position P of the positioning device by comparing the model for each receiving element with the measured received signal for each receiving element.

Abstract: The present invention relates to a model based positioning system that includes a positioning device having at least one transmitter configured to be in a tracking environment, e.g. inserted into a body, a receiver having a plurality of receiver elements arranged outside the tracking environment, a control unit configured to measure amplitude and/or phase information of a signal transmitted from the at least one transmitter and received at each receiving element, and a memory unit M for storing a model for each receiving element. The control unit is also configured to estimate the position P of the positioning device by comparing the model for each receiving element with the measured received signal for each receiving element.

Abstract: The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.

Abstract: A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs, and ii) administering locally into the prostate a controlled release pharmaceutical composition comprising one or more active substances in a biodegradable ceramic carrier. The biodegradable hydrating ceramic may be selected from the group consisting of non-hydrated or hydrated calcium sulphate, calcium phosphate, calcium carbonate, calcium fluoride, calcium silicate, magnesium sulphate, magnesium phosphate, magnesium carbonate, magnesium fluoride, magnesium silicate, barium sulphate, barium phosphate, barium carbonate, barium fluoride, barium silicate, or mixtures thereof. In a specific embodiment, the biodegradable hydrating ceramic is non-hydrated or hydrated calcium sulphate.

Abstract: The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.

Abstract: The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.

Abstract: The present invention relates to a positioning device 10, 20, 30, 40, 50 arranged in relation to a target area inside a body. The device comprises at least one transmitter 11, 21-22, 32, 41, 51, and each transmitter is arranged to emit an electromagnetic signal. The electromagnetic signal is adapted to propagate with a wavelength in the body so that a phase difference and/or an amplitude difference of said electromagnetic signal in at least three positions 18 is detectable by a receiver 19 for tracking variations of a position of the positioning device relative to the receiver. The wavelength is selected so that a distance from the transmitter to each of the three positions is within the same integer number of wavelengths of the electromagnetic signal. Each transmitter is connectable to an externally arranged control unit 15, where said electromagnetic signal of each transmitter is generated before transmission. Each transmitter and receiver preferably operates in a near field region.

Abstract: The present invention relates to a method and device for non-invasive analysis of the identity and concentration of drugs that are to be administered by injection or infusion.

Abstract: The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.

Abstract: The present invention relates to a radiation monitoring device 2; 20; 30; 40; 50; 60; 79, such as an implant or plaster, fixable relative to a target area 1; 73; 84 within a living body 10; 74. The radiation monitoring device is provided with at least one internal element Tx; Tx/Rx; 61, 62 for tracking variations of a position of the device relative to a radiation source 76, 82 arranged outside said target area 1, 73, 84. The radiation monitoring device is further provided with a dose measuring device to detect an administrated dose from the radiation source.

Abstract: A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs, and ii) administering locally into the prostate a controlled release pharmaceutical composition comprising one or more active substances in a biodegradable ceramic carrier. The biodegradable hydrating ceramic may be selected from the group consisting of non-hydrated or hydrated calcium sulphate, calcium phosphate, calcium carbonate, calcium fluoride, calcium silicate, magnesium sulphate, magnesium phosphate, magnesium carbonate, magnesium fluoride, magnesium silicate, barium sulphate, barium phosphate, barium carbonate, barium fluoride, barium silicate, or mixtures thereof. In a specific embodiment, the biodegradable hydrating ceramic is non-hydrated or hydrated calcium sulphate.

Abstract: The present invention relates to a model based positioning system 10; 90 that comprises a positioning device 11; 31 having at least one transmitter configured to be in a tracking environment, e.g. inserted into a body 1, a receiver 13 having a plurality of receiver elements 14 arranged outside the tracking environment, a control unit 18; 93 configured to measure amplitude and/or phase information of a signal transmitted from the at least one transmitter and received at each receiving element, and a memory unit M; 15 for storing a model for each receiving element. The control unit is also configured to estimate the position P of the positioning device by comparing the model for each receiving element with the measured received signal for each receiving element.

Abstract: The present invention relates to an antenna system (1, 101, 201, 301, 401, 501) for tracking of a position of a target area (33, 133, 233, 333, 433, 533) within a body (5, 105, 205, 305, 405, 505), comprising a first antenna device (3, 103, 203, 303, 403, 503) and a second antenna device (9, 109, 209, 309, 409, 509), at least said second antenna device (9, 109, 209, 309, 409, 509) is to be located outside said body (5, 105, 205, 305, 405, 505), wherein an interface region (13, 113, 213, 313, 413, 513) between said body (5, 105, 205, 305, 405, 505) and at least said second antenna device (9, 109, 209, 309, 409, 509) at least partially consist of a dielectric medium having a relative permittivity closer to the permittivity of material within the body (5, 105, 205, 305, 405, 505) than the permittivity of air.

Abstract: The present invention relates to an implant (115) fixable relative to a target area (117) within a living body (105), comprising a transmitter (7; 107; 207; 307) arranged to emit an electromagnetic signal, wherein said electromagnetic signal is adapted to propagate with a wavelength 2 in said living body (105) so that a phase difference of said electromagnetic signal in at least three positions, preferably four, separated by a known distance (b) is detectable by a receiver (9; 109; 209; 309) for tracking variations of a position (p) of the implant (115) relative to said receiver (9; 109; 209; 309). Further, the present invention relates to an apparatus (1; 101; 201; 301), a system and a method for tracking a position (p) of a transmitter (7; 107; 207; 307). Additionally, the invention relates to the use of such a method for treatment of a target area (117) in a living body (105) by means of a radiation therapy treatment arrangement (100).

Abstract: The present invention relates to a method and device for non-invasive analysis of the identity and concentration of drugs that are to be administered by injection or infusion.

Abstract: A pharmaceutical composition for the treatment of acute pain by sublingual administration is described. The composition comprises an essentially water-free, ordered mixture of fentanyl or a pharmaceutically acceptable salt thereof in the form of microparticles which are adhered to the surface of carrier particles which are substantially larger than the particles of fentanyl, and are essentially water-soluble. In a preferred embodiment, the composition also contains a bioadhesion and/or mucoadhesion promoting agent. The invention also relates to the preparation of the composition, and to the use of the composition for the treatment of acute pain.