Patents by Inventor Bo Liedberg
Bo Liedberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11471269Abstract: Disclosed is an optical cylinder of a corneal prosthesis comprising: a) an optical cylinder comprising a solid polymer, and b) a plurality of nanoparticles forming a substantially uniform layer on a circumference of the solid polymer surface of the optical cylinder. Also disclosed are methods of surface treatment of optical cylinders of corneal prostheses, and corneal prostheses thereof.Type: GrantFiled: July 26, 2017Date of Patent: October 18, 2022Assignees: Singapore Health Services Pte Ltd, Nanyang Technological UniversityInventors: Jodhbir Mehta, Andri Riau, Subramanian Venkatraman, Bo Liedberg, Debasish Mondal
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Publication number: 20220205015Abstract: The invention provides a method for detecting bacteria. The method utilises a peptide that forms a complex with a conjugated reporter polymer and is susceptible to cleavage by one or more proteases on the surface of a bacteria. Presence or absence of the bacteria can be determined by assessing the optical absorption and/or colour and/or photoluminescence (e.g. fluorescence) of the conjugated reporter polymer, which may undergo a conformational change after binding with the to the cleaved peptide substrate. Specifically, the peptide substrate may comprise a cleavage site for digestion by the protease, and the protease may be an omptin protease. The conjugated reporter polymer may be selected from a polythiophene, a poly(1,4-phenylene vinylene) (PPV), a poly(1,4-phenylene) (PPP), a polyfluorenes (PFO), a nitrogen-containing polymer such as polyquinoline, poly(2,5-pyridinevinylene) (PPyV), 1,3,4-oxadiazole, and poly(9-vinylcarbazole) (PVK), and a polypyrrole.Type: ApplicationFiled: April 27, 2020Publication date: June 30, 2022Inventors: Bo LIEDBERG, Palaniappan ALAGAPPAN, Sushanth GUDLUR, Gaurav SINSINBAR, Gopal AMMANATH, Milan MRKSICH, Sarah Elizabeth WOOD
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Tubular and vesicular architectures formed from polymer-lipid blends and method for forming the same
Patent number: 10710044Abstract: The invention relates to self-assembled architectures formed from polymer-lipid blends, and in particular, to tubular and vesicular self-assembled architectures formed from polymer-lipid blends. The invention further relates to a method for forming the tubular and vesicular self-assembled architectures. The invention provides a composition comprising a lipid and an amphiphilic block copolymer, wherein the amphiphilic block copolymer is capable of undergoing self-assembly to form an architecture of a first geometry, wherein the composition undergoes self-assembly to form a bilayer architecture enclosing a volume of a second geometry, wherein the second geometry is different from that of the first geometry.Type: GrantFiled: March 29, 2016Date of Patent: July 14, 2020Assignee: NANYANG TECHNOLOGICAL UNIVERSITYInventors: Madhavan Nallani, Bo Liedberg, Atul Parikh, Hans-Peter De Hoog, Amit Kumar Khan, Seng Koon Lim -
Publication number: 20190151076Abstract: Disclosed is an optical cylinder of a corneal prosthesis comprising: a) an optical cylinder comprising a solid polymer, and b) a plurality of nanoparticles forming a substantially uniform layer on a circumference of the solid polymer surface of the optical cylinder. Also disclosed are methods of surface treatment of optical cylinders of corneal prostheses, and corneal prostheses thereof.Type: ApplicationFiled: July 26, 2017Publication date: May 23, 2019Inventors: Jodhbir Mehta, Andri Riau, Subramanian Venkatraman, Bo Liedberg, Debasish Mondal
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TUBULAR AND VESICULAR ARCHITECTURES FORMED FROM POLYMER-LIPID BLENDS AND METHOD FOR FORMING THE SAME
Publication number: 20180126353Abstract: The invention relates to self-assembled architectures formed from polymer-lipid blends, and in particular, to tubular and vesicular self-assembled architectures formed from polymer-lipid blends. The invention further relates to a method for forming the tubular and vesicular self-assembled architectures. The invention provides a composition comprising a lipid and an amphiphilic block copolymer, wherein the amphiphilic block copolymer is capable of undergoing self-assembly to form an architecture of a first geometry, wherein the composition undergoes self-assembly to form a bilayer architecture enclosing a volume of a second geometry, wherein the second geometry is different from that of the first geometry.Type: ApplicationFiled: March 29, 2016Publication date: May 10, 2018Applicant: NANYANG TECHNOLOGICAL UNIVERSITYInventors: Madhavan NALLANI, Bo LIEDBERG, Atul PARIKH, Hans-Peter DE HOOG, Amit Kumar KHAN, Seng Koon LIM -
Publication number: 20120202218Abstract: A method for determining the presence of a compound in a liquid solution, by admixing the liquid solution with a plurality of nanoparticles; providing conditions effective to cause aggregation of the nanoparticles in the liquid solution in the absence of said compound in the liquid solution; and observing a detectable signal reflecting the amount of aggregation of nanoparticles in the liquid solution, wherein the presence of the compound in the liquid solution results in a detectable signal reflecting a reduced amount of aggregation of nanoparticles in the liquid solution, in comparison to the amount of aggregation of nanoparticles obtained in the liquid solution in the absence of the compound therein. A nanoparticle, a composition, a kit and a for multi-well plate for use in the method are also disclosed. In some embodiments the association is cation-, anion and/or PH induced e.g. by using helix-loop-helix polypeptides as first and second molecules attached to the nanoparticles.Type: ApplicationFiled: September 14, 2009Publication date: August 9, 2012Applicant: MODPRO ABInventors: Bo Liedberg, Daniel Aili, Lars Baltzer, Karin Enander, Johan Rydberg
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Publication number: 20100099575Abstract: Novel peptide having a sequence according to SEQ. ID. No. 1, SEQ. ID. No. 2 and/or SEQ. ID. No. 3 are disclosed and also polypeptide scaffold consisting of a four helix bundle formed of two dimerized helix-loop-helix motifs, said helix-loop-helix motifs having sequences according to SEQ. ID. No. 1, SEQ. ID. No. 2 and/or SEQ. ID. No. 3 which may comprise a fluorescent probe at the side chain of Lys15 and a ligand with affinity for a target molecule at the side chain of Lys8 or Lys34. Also disclosed are polypeptide scaffolds for use in biosensing applications with or without the polypeptide scaffold anchored to a solid surface.Type: ApplicationFiled: July 31, 2009Publication date: April 22, 2010Applicant: MODPRO ABInventors: Lars Baltzer, Gunnar Dolphin, Bo Liedberg, Ingemar Lundstrom
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Patent number: 7569661Abstract: Novel peptide having a sequence according to SEQ. ID. No. 1, SEQ. ID. No. 2 and/or SEQ. ID. No. 3 are disclosed and also polypeptide scaffold consisting of a four helix bundle formed of two dimerized helix-loop-helix motifs, said helix-loop-helix motifs having sequences according to SEQ. ID. No. 1, SEQ. ID. No. 2 and/or SEQ. ID. No. 3 which may comprise a fluorescent probe at the side chain of Lys15 and a ligand with affinity for a target molecule at the side chain of Lys8 or Lys34. Also disclosed are polypeptide scaffolds for use in biosensing applications with or without the polypeptide scaffold anchored to a solid surface.Type: GrantFiled: March 26, 2003Date of Patent: August 4, 2009Assignee: Modpro ABInventors: Lars Baltzer, Gunnar Dolphin, Bo Liedberg, Ingemar Lundström
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Publication number: 20090168068Abstract: A coated metal surface on a solid support, wherein the coating consists of a self-assembled monolayer (SAM) of oligo(ethylene glycol)-terminated amide group-containing alkyl thiols firmly attached to the metal surface via the thiol-end and low molecular weight antigens bound via an amide-group to the SAM-forming OEG molecule, wherein the alkyl portion has 1-20 methylene groups, wherein the oligo(ethylene glycol) portion has 1-15 ethylene oxy units, and wherein the antigens, such as explosives and narcotics, are optionally reversibly bound to antibodies specific for the antigens, is disclosed. The coated metal surface on a solid support may be used in a method of detecting analyte antigens as part of an analysis device, such as a Piezoelectric Crystal Microbalance device or a Surface Plasmon Resonance biosensor, for detection in an aqueous solution of an analyte antigen with higher affinity to an antibody than the antigen of the coating by monitoring the displacement of the antibody from the coating.Type: ApplicationFiled: October 23, 2008Publication date: July 2, 2009Applicant: BIOSENSOR APPLICATION SWEDEN ABInventors: Per Mansson, Bo Liedberg
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Publication number: 20060057635Abstract: A coated metal surface on a solid support, wherein the coating consists of a self-assembled monolayer (SAM) of oligo(ethylene glycol)-terminated amide group-containing alkyl thiols firmly attached to the metal surface via the thiol-end and low molecular weight antigens bound via an amide-group to the SAM-forming OEG molecule, wherein the alkyl portion has 1-20 methylene groups, wherein the oligo(ethylene glycol) portion has 1-15 ethylene oxy units, and wherein the antigens, such as explosives and narcotics, are optionally reversibly bound to antibodies specific for the antigens, is disclosed. The coated metal surface on a solid support may be used in a method of detecting analyte antigens as part of an analysis device, such as a Piezoelectric Crystal Microbalance device or a Surface Plasmon Resonance biosensor, for detection in an aqueous solution of an analyte antigen with higher affinity to an antibody than the antigen of the coating by monitoring the displacement of the antibody from the coating.Type: ApplicationFiled: June 18, 2003Publication date: March 16, 2006Inventors: Per Mansson, Bo Liedberg
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Publication number: 20050245727Abstract: Novel peptide having a sequence according to SEQ. ID. No. 1, SEQ. ID. No. 2 and/or SEQ. ID. No. 3 are disclosed and also polypeptide scaffold consisting of a four helix bundle formed of two dimerized helix-loop-helix motifs, said helix-loop-helix motifs having sequences according to SEQ. ID. No. 1, SEQ. ID. No. 2 and/or SEQ. ID. No. 3 which may comprise a fluorescent probe at the side chain of Lys15 and a ligand with affinity for a target molecule at the side chain of Lys8 or Lys34. Also disclosed are polypeptide scaffolds for use in biosensing applications with or without the polypeptide scaffold anchored to a solid surface.Type: ApplicationFiled: March 26, 2003Publication date: November 3, 2005Applicant: Lars BALTZERInventors: Lars Baltzer, Gunnar Dolphin, Bo Liedberg, Ingemar Lundstrom