Patents by Inventor Bo Luo

Bo Luo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240067672
    Abstract: Provided are a flavone derivative represented by formula I and a pharmaceutically acceptable salt, hydrate or solvate thereof. (I) In formula I, R1 is selected from the group consisting of H, C1-4 alkyl, amino and C1-4 acyl; R2 is isopentenyl or 2-hydroxy-isopentyl; R3 is selected from the group consisting of H, methyl and deuterated methyl; R4 is selected from the group consisting of C1-4 alkyl, amino, C1-4 acyl, and (II), wherein R5 represents a monosaccharide residue or an oligosaccharide residue; L is selected from the group consisting of a polypeptide, C1-C20 linear alkyl or a derivative thereof, a derivative of C1-C20 linear or branched acyl, C1-C20 glycol or a derivative thereof, and (III), wherein Y is (IV), a is an integer from 0-100, b is an integer from 1-100, c is an integer from 1-10, d is an integer from 0-100, and e is an integer from 0-100. The flavone derivative according to the present invention exhibits an potent and broad-spectrum anti-cancer activity.
    Type: Application
    Filed: June 8, 2020
    Publication date: February 29, 2024
    Inventors: Yongmei Xie, Xiangrong Song, Bo Luo
  • Patent number: 11572382
    Abstract: The invention relates to novel camptothecin derivatives and their applications, tumor cell growth inhibitors, ternary complexes, and a method for improving the solubility of the camptothecin derivatives. The camptothecin derivatives are prepared by modifying the substance shown as Formula I with glycosylated triazole at position R3. In the structure shown as Formula I, R1 represents H, C1-10 alkyl, C1-10 alkyl-D or C1-10 haloalkyl; R2 represents H, CH2N(CH3)2 or CH2N(CD3)2; and R4 represents or H, wherein X represents N, O or S; and L represents polypeptide, C1-20 linear alkyl or derivatives thereof, C1-20 linear or branched acyl derivatives, C2-100 ethylene glycol or derivatives thereof. The camptothecin derivatives have high solubility, the anticancer drugs prepared from them have the advantages of wide anticancer spectrum and high safety, and have in vivo anticancer activity higher than irinotecan hydrochloride.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: February 7, 2023
    Assignee: TARGET BIOPHARMACEUTICAL TECHNOLOGY SHENZHEN COMPANY LIMITED
    Inventors: Yongmei Xie, Xiangrong Song, Xifei Yang, Yu Zhao, Bo Luo
  • Publication number: 20210246157
    Abstract: The invention relates to novel camptothecin derivatives and their applications, tumor cell growth inhibitors, ternary complexes, and a method for improving the solubility of the camptothecin derivatives. The camptothecin derivatives are prepared by modifying the substance shown as Formula I with glycosylated triazole at position R3. In the structure shown as Formula I, R1 represents H, C1-10 alkyl, C1-10 alkyl-D or C1-10 haloalkyl; R2 represents H, CH2N(CH3)2 or CH2N(CD3)2; and R4 represents or H, wherein X represents N, O or S; and L represents polypeptide. C1-20 linear alkyl or derivatives thereof. C1-20 linear or branched acyl derivatives, C2-100 ethylene glycol or derivatives thereof. The camptothecin derivatives have high solubility, the anticancer drugs prepared from them have the advantages of wide anticancer spectrum and high safety, and have in vivo anticancer activity higher than irinotecan hydrochloride.
    Type: Application
    Filed: August 15, 2019
    Publication date: August 12, 2021
    Inventors: Yongmei XIE, Xiangrong SONG, Xifei YANG, Yu ZHAO, Bo LUO
  • Patent number: 10781565
    Abstract: The invention relates to a water intake floating row cleaning system, including first vertical guide rail assemblies, a floating row, submersible pumps, water spraying assemblies, second vertical guide rail assemblies, floating fences and pumping assemblies, wherein the water spraying assemblies are communicated with the submersible pumps, and the submersible pumps pump the water of the river channel and spray the water towards the outside through the water spraying assemblies; and the floating fences stretch across the water intakes and float along with a water level, and the pumping assemblies are used for pumping out garbage blocked by the floating fences. The invention has the effect of efficiently cleaning the floating garbage at the water intakes.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: September 22, 2020
    Assignee: Shenzhen Shenshui Water Resources Consulting Co., LTD.
    Inventors: Xuerang Deng, Laihui Luo, Lihan Yang, Bo Luo, Weibin Peng, Fengying Zhang
  • Publication number: 20190368148
    Abstract: The invention relates to a water intake floating row cleaning system, including first vertical guide rail assemblies, a floating row, submersible pumps, water spraying assemblies, second vertical guide rail assemblies, floating fences and pumping assemblies, wherein the water spraying assemblies are communicated with the submersible pumps, and the submersible pumps pump the water of the river channel and spray the water towards the outside through the water spraying assemblies; and the floating fences stretch across the water intakes and float along with a water level, and the pumping assemblies are used for pumping out garbage blocked by the floating fences. The invention has the effect of efficiently cleaning the floating garbage at the water intakes.
    Type: Application
    Filed: June 21, 2019
    Publication date: December 5, 2019
    Inventors: Xuerang Deng, Laihui Luo, Lihan Yang, Bo Luo, Weibin Peng, Fengying Zhang
  • Patent number: 10262130
    Abstract: A system and method for providing cryptographic operation service in a virtualization environment. In the system, a configuration subsystem provides an interface for an administrator and a common user to input information about a virtual cryptographic device. A key file storage subsystem stores a key file and protects it with the protection password. A virtual machine operating subsystem obtains a corresponding key file from the storage subsystem according to the input of the configuration subsystem, creates a virtual device for a guest virtual machine, and finally operates the guest virtual machine to provide cryptographic computing service for the guest virtual machine. Thus the administrator/the common user can specify a key file and input a protection password for a guest virtual machine via the corresponding interface to facilitate the creation of a virtual cryptographic device, and can manage the virtual cryptographic device in a user-friendly and centralized manner.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: April 16, 2019
    Assignee: DATA ASSURANCE & COMMUNICATION SECURITY CENTER, CHINESE ACADEMY OF SCIENCES
    Inventors: Jingqiang Lin, Kaijie Zhu, Lingchen Zhang, Bo Luo, Quanwei Cai, Congwu Li, Jiwu Jing, Wuqiong Pan
  • Publication number: 20180232519
    Abstract: A system and method for providing cryptographic operation service in a virtualization environment. In the system, a configuration subsystem provides an interface for an administrator and a common user to input information about a virtual cryptographic device. A key file storage subsystem stores a key file and protects it with the protection password. A virtual machine operating subsystem obtains a corresponding key file from the storage subsystem according to the input of the configuration subsystem, creates a virtual device for a guest virtual machine, and finally operates the guest virtual machine to provide cryptographic computing service for the guest virtual machine. Thus the administrator/the common user can specify a key file and input a protection password for a guest virtual machine via the corresponding interface to facilitate the creation of a virtual cryptographic device, and can manage the virtual cryptographic device in a user-friendly and centralized manner.
    Type: Application
    Filed: October 22, 2015
    Publication date: August 16, 2018
    Inventors: Jingqiang Lin, Kaijie Zhu, Lingchen Zhang, Bo Luo, Quanwei Cai, Congwu Li, Jiwu Jing, Wuqiong Pan
  • Patent number: 9075825
    Abstract: The present invention includes a system and methods for image searching. Embodiments of the system integrate textual features and visual features for improved search performance. The system represents text terms in the visual feature space and develops a text-guided weighting scheme for visual features. The weighting scheme infers intention from query terms and enhances the visual features that are significant in light of such intention.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: July 7, 2015
    Assignee: The University of Kansas
    Inventors: Xue-wen Chen, Bo Luo
  • Patent number: 8704329
    Abstract: SOI devices for plasma display panel driver chip, include a substrate, a buried oxide layer and an n-type SOI layer in a bottom-up order, where the SOI layer is integrated with an HV-NMOS device, an HV-PMOS device, a Field-PMOS device, an LIGBT device, a CMOS device, an NPN device, a PNP device and an HV-PNP device; the SOI layer includes an n+ doped region within the SOI layer at an interface between the n-type SOI layer and the buried oxide layer; and the n+ doped region has a higher doping concentration than the n-type SOI layer.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: April 22, 2014
    Assignee: University of Electronic Science and Technology of China
    Inventors: Ming Qiao, Bo Luo, Xi Hu, Jun Ye, Bo Zhang, Zhaoji Li
  • Publication number: 20130256800
    Abstract: SOI devices for plasma display panel driver chip, include a substrate, a buried oxide layer and an n-type SOI layer in a bottom-up order, where the SOI layer is integrated with an HV-NMOS device, an HV-PMOS device, a Field-PMOS device, an LIGBT device, a CMOS device, an NPN device, a PNP device and an HV-PNP device; the SOI layer includes an n+ doped region within the SOI layer at an interface between the n-type SOI layer and the buried oxide layer; and the n+ doped region has a higher doping concentration than the n-type SOI layer.
    Type: Application
    Filed: December 29, 2010
    Publication date: October 3, 2013
    Applicant: UNIVERSITY OF ELECTRONIC SCIENCE AND TECHNOLOGY OF CHINA
    Inventors: Ming Qiao, Bo Luo, Xi Hu, Jun Ye, Bo Zhang, Zhaoji Li
  • Publication number: 20130080426
    Abstract: The present invention includes a system and methods for image searching. Embodiments of the system integrate textual features and visual features for improved search performance. The system represents text terms in the visual feature space and develops a text-guided weighting scheme for visual features. The weighting scheme infers intention from query terms and enhances the visual features that are significant in light of such intention.
    Type: Application
    Filed: September 26, 2012
    Publication date: March 28, 2013
    Inventors: Xue-wen Chen, Bo Luo
  • Patent number: D964633
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: September 20, 2022
    Inventor: Bo Luo
  • Patent number: D983000
    Type: Grant
    Filed: May 10, 2022
    Date of Patent: April 11, 2023
    Inventor: Bo Luo