Patents by Inventor Boru Zhu

Boru Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11442035
    Abstract: A method of depositing reagent on an electrochemical test sensor adapted to determine information relating to an analyte includes providing a base and forming an electrode pattern on the base. The method further includes depositing the reagent on at least the electrode pattern using a reagent-dispensing system. The reagent-dispensing system applies mechanical force to the reagent in the reagent-dispensing system to assist in providing a wet reagent droplet on at least the electrode pattern.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: September 13, 2022
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Boru Zhu, Herbert Henley, Jr.
  • Patent number: 11180790
    Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: November 23, 2021
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
  • Patent number: 10988610
    Abstract: An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: April 27, 2021
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Paul Valint, Jr., Doug H. Williamson, Boru Zhu
  • Publication number: 20200362158
    Abstract: An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.
    Type: Application
    Filed: April 14, 2020
    Publication date: November 19, 2020
    Inventors: Paul Valint, JR., Doug H. Williamson, Boru Zhu
  • Publication number: 20200270668
    Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.
    Type: Application
    Filed: May 13, 2020
    Publication date: August 27, 2020
    Inventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
  • Patent number: 10696998
    Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: June 30, 2020
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
  • Patent number: 10655004
    Abstract: An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: May 19, 2020
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Paul Valint, Jr., Doug H. Williamson, Boru Zhu
  • Patent number: 10647846
    Abstract: An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: May 12, 2020
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Paul Valint, Doug H. Williamson, Boru Zhu
  • Publication number: 20190136038
    Abstract: An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.
    Type: Application
    Filed: January 3, 2019
    Publication date: May 9, 2019
    Inventors: Paul Valint, JR., Doug H. Williamson, Boru Zhu
  • Publication number: 20190136037
    Abstract: An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.
    Type: Application
    Filed: December 28, 2018
    Publication date: May 9, 2019
    Inventors: Paul Valint, Doug H. Williamson, Boru Zhu
  • Publication number: 20190078131
    Abstract: A reagent composition for a biosensor sensor strip is disclosed that provides for rapid rehydration after drying. The composition includes porous particles and is preferably formed as a colloidal suspension. The dried reagent composition including porous particles may provide analytically useful output from the sensor strip in a shorter time period than observed from dried reagent compositions using solid particles. The output signal from the porous particle compositions may be correlated to the analyte concentration of a sample within about two seconds. In this manner, an accurate concentration determination of an analyte concentration in a sample may be obtained in less time than from sensor strips including conventional compositions. The reagent composition including the porous particles also may allow for the redox reaction between the reagents and the analyte to reach a maximum kinetic performance in a shorter time period than observed from conventional sensor strips.
    Type: Application
    Filed: November 13, 2018
    Publication date: March 14, 2019
    Inventor: Boru Zhu
  • Patent number: 10227485
    Abstract: An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: March 12, 2019
    Assignee: Ascensia Diabetics Care Holdings AG
    Inventors: Paul Valint, Doug H. Williamson, Boru Zhu
  • Patent number: 10196512
    Abstract: An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: February 5, 2019
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Paul Valint, Jr., Doug H. Williamson, Boru Zhu
  • Patent number: 10150981
    Abstract: A reagent composition for a biosensor sensor strip is disclosed that provides for rapid rehydration after drying. The composition includes porous particles and is preferably formed as a colloidal suspension. The dried reagent composition including porous particles may provide analytically useful output from the sensor strip in a shorter time period than observed from dried reagent compositions using solid particles. The output signal from the porous particle compositions may be correlated to the analyte concentration of a sample within about two seconds. In this manner, an accurate concentration determination of an analyte concentration in a sample may be obtained in less time than from sensor strips including conventional compositions. The reagent composition including the porous particles also may allow for the redox reaction between the reagents and the analyte to reach a maximum kinetic performance in a shorter time period than observed from conventional sensor strips.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: December 11, 2018
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventor: Boru Zhu
  • Publication number: 20180242913
    Abstract: A multi-layer pad that is adapted to be used in determining an analyte concentration is disclosed. The multi-layer pad includes a first layer, a second layer, and a third layer. The first layer includes an enzyme wherein the enzyme is adapted to assist in determining the analyte concentration. The second layer is attached to a first surface of the first layer. The second layer is made of a skin-conforming material. The third layer is attached to a second surface of the first layer wherein the first layer is located between the second layer and the third layer. It is contemplated that the multi-layer pad may also be a two layer system.
    Type: Application
    Filed: April 30, 2018
    Publication date: August 30, 2018
    Inventors: Boru Zhu, Mihailo V. Rebec, Pamela J. Burson
  • Patent number: 9993202
    Abstract: A multi-layer pad that is adapted to be used in determining an analyte concentration is disclosed. The multi-layer pad includes a first layer, a second layer, and a third layer. The first layer includes an enzyme wherein the enzyme is adapted to assist in determining the analyte concentration. The second layer is attached to a first surface of the first layer. The second layer is made of a skin-conforming material. The third layer is attached to a second surface of the first layer wherein the first layer is located between the second layer and the third layer. It is contemplated that the multi-layer pad may also be a two layer system.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: June 12, 2018
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventors: Boru Zhu, Mihailo V. Rebec, Pamela J. Burson
  • Publication number: 20180059042
    Abstract: A method of depositing reagent on an electrochemical test sensor adapted to determine information relating to an analyte includes providing a base and forming an electrode pattern on the base. The method further includes depositing the reagent on at least the electrode pattern using a reagent-dispensing system. The reagent-dispensing system applies mechanical force to the reagent in the reagent-dispensing system to assist in providing a wet reagent droplet on at least the electrode pattern.
    Type: Application
    Filed: November 1, 2017
    Publication date: March 1, 2018
    Inventors: Boru Zhu, Herbert Henley, Jr.
  • Publication number: 20170349929
    Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.
    Type: Application
    Filed: August 21, 2017
    Publication date: December 7, 2017
    Inventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
  • Patent number: 9829459
    Abstract: A method of depositing reagent on an electrochemical test sensor adapted to determine information relating to an analyte includes providing a base and forming an electrode pattern on the base. The method further includes depositing the reagent on at least the electrode pattern using a reagent-dispensing system. The reagent-dispensing system applies mechanical force to the reagent in the reagent-dispensing system to assist in providing a wet reagent droplet on at least the electrode pattern.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: November 28, 2017
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Boru Zhu, Herbert Henley, Jr.
  • Publication number: 20170145203
    Abstract: An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.
    Type: Application
    Filed: December 16, 2016
    Publication date: May 25, 2017
    Inventors: Paul Valint, JR., Doug H. Williamson, Boru Zhu