Patents by Inventor Bo SALOMONSEN

Bo SALOMONSEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MICROBIAL CELL FACTORIES PRODUCING VITAMIN B COMPOUNDS
    Publication number: 20240368659
    Abstract: The present disclosure relates to a genetically modified host cell having increased production of one or more vitamin B compounds, wherein the host cell is genetically modified by mutating one or more native polynucleotide constructs for reducing formation of a CRP-cAMP complex in the host cell and/or introducing one or more genetic alterations increasing the degradation and/or non-CRP binding of cAMP in the host cell; whereby the production of the vitamin B compound in the genetically modified host cell is increased compared to a parent host cell.
    Type: Application
    Filed: July 14, 2022
    Publication date: November 7, 2024
    Inventors: Carlos Guillermo ACEVEDO-ROCHA, Daniel Boer BONIFACIO, Benjamin Joseph CADDELL, Hans Jasper GENEE, Luisa Simona GRONENBERG, Kathleen Frances SMART, Nils MYLING-PETERSEN, Bo SALOMONSEN, Gijs VERKLEIJ
  • Genetically modified bacterial cell factory for thiamine production
    Patent number: 10696992
    Abstract: The invention provides a genetically modified bacterium for production of thiamine; where the bacterium is characterized by a transgene encoding a thiamine monophosphate phosphatase (TMP phosphatase having EC 3.1.3.-) as well as transgenes encoding polypeptides that catalyze steps in the thiamine pathway. The genetically modified bacterium is characterized by enhanced synthesis and release of thiamine into the extracellular environment. The invention further provides a method for producing thiamine using the genetically modified bacterium of the invention; as well as the use of the genetically modified bacterium for extracellular thiamine production.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: June 30, 2020
    Assignee: BIOSYNTHIA APS
    Inventors: Luisa Gronenberg, Bo Salomonsen, Matteo Ferla, Hans Jasper Genee
  • A GENETICALLY MODIFIED BACTERIAL CELL FACTORY FOR THIAMINE PRODUCTION
    Publication number: 20190382815
    Abstract: The invention provides a genetically modified bacterium for production of thiamine; where the bacterium is characterized by a transgene encoding a thiamine monophosphate phosphatase (TMP phosphatase having EC 3.1.3.-) as well as transgenes encoding polypeptides that catalyze steps in the thiamine pathway. The genetically modified bacterium is characterized by enhanced synthesis and release of thiamine into the extracellular environment. The invention further provides a method for producing thiamine using the genetically modified bacterium of the invention; as well as the use of the genetically modified bacterium for extracellular thiamine production.
    Type: Application
    Filed: December 16, 2016
    Publication date: December 19, 2019
    Applicant: BIOSYNTIA APS
    Inventors: Luisa GRONENBERG, Bo SALOMONSEN, Matteo FERLA, Hans Jasper GENEE