Abstract: Provided are crystalline forms of a KRAS G12C inhibitor compound and to processes for their preparation. Furthermore, provided is pharmaceutical composition comprising said crystalline forms, and at least one pharmaceutically acceptable excipient. The pharmaceutical composition can be used as a medicament, in particular for the treatment of cancer, and KRAS G12C-mutant cancer.

Abstract: The present disclosure is directed to generative models for datasets constrained by marginal constraints. One method includes receiving a request to generate a target dataset based on a marginal constraint for a source dataset. A first object occurs at a source frequency in the source dataset. The marginal constraint indicates a target frequency for the first object. The source dataset encodes a set of co-occurrence frequencies for a plurality of object pairs. A source generative model is accessed. The source generative model includes a first module and a second module that are trained on the source dataset. The second module is updated based on the marginal constraint. An adapted generative model is generated that includes the first module and the updated second module. The target dataset is generated based on the adapted generative model. The first object occurs at the target frequency in the target dataset. The target dataset encodes the set of co-occurrence frequencies for the plurality of object pairs.

Abstract: The invention relates to a method for preparing high-stability liquid blueberry anthocyanins, belonging to the field of food processing. A method for preparing high-stability liquid blueberry anthocyanins comprises the following process steps: adding graphene oxide and chitosan to an MES buffer solution at room temperature, mixing homogeneously and adding EDC and NHS sequentially, reacting to obtain a first solution; adding dry blueberry anthocyanin powder in the first solution, adjusting pH to 4.5 to 5.0 and mixing homogeneously to obtain a second solution, and treating the second solution at 350 to 420 MPa and 2 to 4° C. to obtain the product. The method for increasing the stability of blueberry anthocyanins provided by the present invention uses dry blueberry anthocyanin powder as a raw material and adds graphene oxide combined with chitosan compound as an anthocyanin stabilizer, thereby increasing the stability of blueberry anthocyanins during processing and production.

Abstract: Provided are catechol nanoparticles, catechol protein nanoparticles, and a preparation method and use thereof. The method includes: adding a tannin compound-containing natural herb medicine into water to obtain a mixture, and subjecting the mixture to heating reflux extraction to obtain a herb medicine extract and subjecting the herb medicine extract to fractionation to obtain the catechol nanoparticles.

Abstract: The embodiments of the present disclosure disclose a self-service express cabinet and a package delivery method. The self-service express cabinet may include: a cabinet body including a sending window and a chamber, wherein the sending window may be connected with the chamber, and the sending window may be disposed on a surface of the cabinet body; a human-machine interaction device disposed on the cabinet body for information interaction with a user; an inspection device disposed in the chamber and capable of performing security inspection on a package dropped into the chamber for delivery, wherein the inspection device may have a receiving end and an output end, and at least part of the receiving end may be located within a scope of a forward projection of the sending window; and at least one storage component disposed in the chamber and corresponding to the output end.

Abstract: A Y-type molecular sieve and a preparation method therefor are provided. The grain size of the molecular sieve is 20-100 nm, preferably 40-70 nm, and more preferably 50-60 nm. The molar ratio of silica/alumina in the molecular sieve is 4.5-7, preferably 5.0-6.5, and more preferably 6.0-6.5. The proportion of 40-70 nm grains in the molecular sieve that is measured by means of a dynamic photoelectron scattering method is 80%-95%, and preferably 85%-93%. The Y-type molecular sieve has a small grain size, concentrated grain distribution, high silica-alumina ratio and good hydrothermal stability, and can meet the needs of industrial production.

Abstract: The present invention relates to a method for producing a bacterial microcompartment virus-like particle (VLP) carrying a cargo molecule, the method comprising introducing and expressing in a host cell or organism one or more polynucleotides comprising (a) a first sequence encoding bacterial microcompartment shell protomers and a second sequence encoding a cargo molecule fused to an encapsulation peptide comprising the sequence SKITGSSGNDTQGSLITYSGGARG, and forming a microcompartment that encapsulates the cargo molecule, or (b) a first sequence encoding bacterial microcompartment shell protomers and a second sequence encoding at least one of said protomers fused with a cargo molecule or a biochemical tag, and forming a microcompartment that expresses the cargo molecule or biochemical tag on an exterior surface. In one embodiment, the bacterial microcompartment protomers are CsoSIA and CsoS4A from Halothiobacillus neapolitanus, or HO-H, HO-P and HO-T1 from Haliangium ochraceum.

Abstract: Provided is a method for processing resources. The method includes: displaying, in response to a trigger operation on a target adjustment control, a task page of a target adjustment task, wherein the task page has participation prompt information and a first invitation control displayed thereon; sending, in response to a trigger operation on the first invitation control, adjustment task information to other one or more accounts; and updating, upon completion of the target adjustment task, a state of a target resource based on the target quantity required for updating the state of the target resource.

Abstract: The invention relates to a method for preparing high-stability liquid blueberry anthocyanins, belonging to the field of food processing. A method for preparing high-stability liquid blueberry anthocyanins comprises the following process steps: adding graphene oxide and chitosan to an MES buffer solution at room temperature, mixing homogeneously and adding EDC and NHS sequentially, reacting to obtain a first solution; adding dry blueberry anthocyanin powder in the first solution, adjusting pH to 4.5 to 5.0 and mixing homogeneously to obtain a second solution, and treating the second solution at 350 to 420 MPa and 2 to 4° C. to obtain the product. The method for increasing the stability of blueberry anthocyanins provided by the present invention uses dry blueberry anthocyanin powder as a raw material and adds graphene oxide combined with chitosan compound as an anthocyanin stabilizer, thereby increasing the stability of blueberry anthocyanins during processing and production.

Abstract: A shaving cutter includes a handle; a head coupled to the handle and at least one groove. The head includes an upper surface; a bottom surface opposite the upper surface and substantially parallel to the upper surface; a first sidewall coupling the upper surface to the bottom surface; and a second sidewall opposite the first sidewall and further coupling the upper surface to the bottom surface. Each groove is protruded from the upper surface, and extends from the upper surface to the second sidewall slantwise and crookedly, and protrudes out from the second sidewall, and further forms a blade on one end of the groove distal from the first sidewall. One part of each groove close to the first sidewall is a cutter back, and the other part of each groove away from the first sidewall is a cutter groove.

Abstract: A workflow UI generating method and generator.