Abstract: Described herein is N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide (Compound A) (Formula I), including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions or pharmaceutical formulations that include the compound, as well as methods of using the compound, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, diabetes, and inflammatory diseases or conditions.

Abstract: A rock true-triaxial testing system based on computerized tomography (CT) scanning aims to solve problems in the prior art, that is, the rigidity of the frame in the testing system is insufficient; high-pressure lines, wires, and signal lines are entangled when rotating; and the reaction frame and loading actuators obstruct the ray. The rock true-triaxial testing system includes a true-triaxial loading system and a high-energy accelerator-based CT scanning system, where the high-energy accelerator-based CT scanning system is located inside the true-triaxial loading system, and the high-energy accelerator-based CT scanning system is configured to image an internal structure of a cubic rock sample and continuously apply a stress to the cubic rock sample through a plurality of piston extension rods in the true-triaxial loading system. The rock true-triaxial testing system reduces radiation attenuation, and ensures imaging quality and a stable and smooth loading process.

Abstract: A magnetic particle imaging system that includes a magnetic field generating system with at least one magnet and providing a gradient magnetic field within an observation region such that the gradient magnetic field has a dynamic field-free region (FFR) for an object under observation having strongly-interacting magnetic particles distributed therein. The magnetic field generating system also includes a drive field and a slow shift field that dynamically shifts the FFR across a field of view (FOV) within the observation region, where the trajectory of the drive field accommodates for a coercivity of the strongly-interacting magnetic particles by ensuring that the particles in the FOV are saturated to a full coercivity field prior to traversing to an opposite-polarity of coercivity. The magnetic particle imaging system also includes a detection system proximate the observation region and configured to detect a signal from the strongly-interacting magnetic particles.

Abstract: A method of determining a location of a measurement device includes determining, at a server: measurement times of first positioning signal measurements, of first positioning signals from first positioning signal sources and/or a subset of positioning signal sources of second positioning signal sources. The method includes sending at least one measurement command from the server to the measurement device to cause the measurement device to obtain the first positioning signal measurements in accordance with the measurement times and/or obtain second positioning signal measurements of second positioning signals sent from the subset of positioning signal sources. The method includes: receiving, at the server from the measurement device, measurement data corresponding to the first positioning signal measurements and/or the second positioning signal measurements; and determining, at the server, the location of the measurement device based on the measurement data.

Abstract: Position, Velocity, and Time (PVT) information of a LEO satellite can be determined by leveraging a known position of a mobile device comprising a terrestrial satellite receiver of the LEO satellite and using range information (range and/or range rate) of the LEO satellite taken at the mobile device. According to some embodiments, this PVT information can be shared by the mobile device with the server and/or other mobile devices, and information from multiple mobile devices can be crowdsourced to determine robust PVT information for a LEO satellite. Once the PVT information is determined, it can be used to subsequently for positioning of the mobile device and/or other mobile devices.

Abstract: The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.

Abstract: The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.

Abstract: Techniques are provided which may be implemented using various methods and/or apparatuses in a vehicle to determine location relative to a roadside unit (RSU) or other nearby point of reference. Vehicles within a pre-designated range or within broadcast distance or otherwise geographically proximate to a roadside unit, through the use of broadcast or other messages sent by the vehicles and/or the RSU may share carrier GNSS phase measurement data, wherein the shared GNSS carrier phase measurement data may be utilized to control and coordinate vehicle movements, velocity and/or position by the RSU and/or to determine location of each vehicle relative to the RSU and/or to other vehicles or determine the absolute location of each vehicle. An RSU may coordinate vehicle access to an intersection, manage vehicle speeds and coordinate or control vehicle actions such as slowing, stopping, and changing lanes or sending a vehicle to a particular location.

Abstract: In an aspect, a user equipment (UE) receives a spoofing alert message from either a server or an internet-of-things (IOT) device that indicates whether a spoofed Global Navigation Satellite System (GNSS) condition is present. Based on determining that the spoofing alert message indicates that a spoofed GNSS condition is present, the UE determines, based on the spoofing alert message, a location of a spoofer broadcasting a spoofed GNSS signal, determines, based on the location of the spoofer and a current location of the UE, that the UE is within a receiving area of the spoofed GNSS signal, and determines a position of the UE without using the spoofed GNSS signal.

Abstract: In an aspect, a user equipment (UE) receives a spoofing alert message from either a server or an internet-of-things (IOT) device that indicates whether a spoofed Global Navigation Satellite System (GNSS) condition is present. Based on determining that the spoofing alert message indicates that a spoofed GNSS condition is present, the UE determines, based on the spoofing alert message, a location of a spoofer broadcasting a spoofed GNSS signal, determines, based on the location of the spoofer and a current location of the UE, that the UE is within a receiving area of the spoofed GNSS signal, and determines a position of the UE without using the spoofed GNSS signal.

Abstract: An etching method for selectively etching a silicon oxide film on a wafer surface that includes the silicon oxide film and a silicon nitride film includes: a surface layer removal process including: etching the silicon oxide film at a first etching rate and removing a surface modification layer covering on the silicon nitride film; and an etching process including: etching the silicon oxide film at a second etching rate. The first etching rate is smaller than the second etching rate.

Abstract: A pulsed magnetic particle imaging system includes a magnetic field generating system that includes at least one magnet, the magnetic field generating system providing a spatially structured magnetic field within an observation region of the magnetic particle imaging system such that the spatially structured magnetic field will have a field-free region (FFR) for an object under observation having a magnetic nanoparticle tracer distribution therein. The pulsed magnetic particle imaging system also includes a pulsed excitation system arranged proximate the observation region, the pulsed excitation system includes an electromagnet and a pulse sequence generator electrically connected to the electromagnet to provide an excitation waveform to the electromagnet, wherein the electromagnet when provided with the excitation waveform generates an excitation magnetic field within the observation region to induce an excitation signal therefrom by at least one of shifting a location or condition of the FFR.

Abstract: The present application describes a sensor apparatus based on chemically functionalized graphene as the sensing materials. The sensing materials is modified from graphene oxide with unique chemical process to form a group of graphene derivatives, e.g. butylamine, hexylamine, decylamine, dodecylamine, benzylamine etc., to detect volatile and non-volatile compounds, e.g. toluene, ethylacetate, ethanol, acetone, hexane etc. with high sensitivity. Pattern recognition algorithms and methods, e.g. PCA, are coupled with the sensors for detecting and quantifying specific chemical compounds. Methods of using the sensor apparatus in applications such as diagnosis of disease and food quality control are disclosed.

Abstract: Techniques are provided which may be implemented using various methods and/or apparatuses in a vehicle to determine location relative to a roadside unit (RSU) or other nearby point of reference. Vehicles within a pre-designated range or within broadcast distance or otherwise geographically proximate to a roadside unit, through the use of broadcast or other messages sent by the vehicles and/or the RSU may share carrier GNSS phase measurement data, wherein the shared GNSS carrier phase measurement data may be utilized to control and coordinate vehicle movements, velocity and/or position by the RSU and/or to determine location of each vehicle relative to the RSU and/or to other vehicles or determine the absolute location of each vehicle. An RSU may coordinate vehicle access to an intersection, manage vehicle speeds and coordinate or control vehicle actions such as slowing, stopping, and changing lanes or sending a vehicle to a particular location.

Abstract: In an aspect, a user equipment (UE) receives a spoofing alert message from either a server or an internet-of-things (IOT) device that indicates whether a spoofed Global Navigation Satellite System (GNSS) condition is present. Based on determining that the spoofing alert message indicates that a spoofed GNSS condition is present, the UE determines, based on the spoofing alert message, a location of a spoofer broadcasting a spoofed GNSS signal, determines, based on the location of the spoofer and a current location of the UE, that the UE is within a receiving area of the spoofed GNSS signal, and determines a position of the UE without using the spoofed GNSS signal.

Abstract: An Real-Time Kinematic (RTK) and/or Differential GNSS (DGNSS) system is disclosed in which correction data from a plurality of reference stations is provided to the mobile device. A selection of reference stations (from which correction data is provided to the mobile device) can be made based on factors such as the approximate location of the mobile device, geometry of the reference stations, and/or other factors. The mobile device can combine the correction data from the plurality of reference stations in different ways to determine an accurate position fix for the mobile device, without interpolating correction data from the plurality of reference stations.

Abstract: Disclosed are techniques for vehicle positioning. In an aspect, a positioning engine aggregator of a host vehicle determines a position estimate of the host vehicle based on one or more position fixes determined by one or more positioning engines of the host vehicle, receives input from a user interface (UI) of the host vehicle to correct the position estimate of the host vehicle, and updates the position estimate of the host vehicle based on the input from the UI.

Abstract: A wearable device that can receive a plurality of Global Navigation Satellite System (GNSS) timing signals using an antenna, where the antenna is located in an exterior portion of the wearable device such that the antenna receives GNSS signals at the external portion of the wearable device, without the GNSS signals first passing through an air gap within a housing of the wearable device. The wearable device is configured to determine a geographic location of the wearable device based at least in part on the GNSS signals. The wearable device is configurable to perform underwater dead-reckoning procedures, measuring energy levels during dwell periods, measuring efficiency of swim strokes, sharing wearable device information with other electronic devices, calibrating the wearable device, or a combination thereof.

Abstract: Aspects presented herein may improve the performance and accuracy of RF-based positioning. Aspects presented herein may enable a device to use RF Doppler measurements to detect and mitigate multipath effects in RF-based positioning. The RF-based positioning may include satellite navigation, terrestrial positioning system, and/or indoor positioning. In one aspect, a UE receives, via a receiver, signals from one or more entities. The UE determines whether each received signal is a multipath signal based on a Doppler shift measurement. The UE de-weights or excludes one or more signals of the received signals in estimating a position of the UE based on whether the respective received signal is determined to be a multipath signal.

Abstract: The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.