Abstract: The present disclosure is directed to a method for cultivating a Bordetella species, comprising: cultivating a Bordetella species under aerobic conditions in a liquid culture medium; and maintaining a pH of the liquid culture medium by using a strong acid, such as nitric acid, or using a first and second acid, wherein the first acid is an inorganic acid that dissociates essentially completely in water, such as nitric acid, hydrochloric acid or sulfuric acid, and wherein the second acid is an inorganic acid having an acid dissociation constant (pKa) of greater than 1, such as phosphoric acid. Methods for increasing the yield of Bordetella fimbrial agglutinogen 2 and fimbrial agglutinogen 3 (FIM2/3) in a supernatant fraction from a Bordetella culture are also provided.

Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.

Abstract: The present invention discloses a Nb and Al-containing titanium-copper alloy strip, characterized in that the weight percentage composition of the titanium-copper alloy strip comprises: 2.00-4.50 wt % Ti, 0.005-0.4 wt % Nb, and 0.01-0.5 wt % Al, balance being Cu and unavoidable impurities. Preferably, in the microstructure of the titanium-copper alloy strip, the number of Nb and Al-containing intermetallic compound particles with a particle size of 50-500 nm is not less than 1×105/mm2, and the number of Nb and Al-containing intermetallic compound particles with a particle size greater than 1 ?m is not more than 1×103/mm2. Under the condition of ensuring excellent bendability, the titanium-copper alloy strip has excellent stability, especially the stability of mechanical properties at high temperatures. The present invention also relates to a method for producing the titanium-copper alloy strip.

Abstract: The present disclosure is directed to a method for cultivating a Bordetella species, comprising: cultivating a Bordetella species under aerobic conditions in a liquid culture medium; and maintaining a pH of the liquid culture medium by using a strong acid, such as nitric acid, or using a first and second acid, wherein the first acid is an inorganic acid that dissociates essentially completely in water, such as nitric acid, hydrochloric acid or sulfuric acid, and wherein the second acid is an inorganic acid having an acid dissociation constant (pKa) of greater than 1, such as phosphoric acid. Methods for increasing the yield of Bordetella finbria agglutinogen 2 and fimbrial agglutinogen 3 (FIM2/3) in a supernatant fraction from a Bordetella culture are also provided.

Abstract: Disclosed is a beam energy dispersion adjusting mechanism for superconducting proton cyclotron. The adjusting mechanism includes a vacuum cavity, bases are symmetrically mounted on outer walls of four faces of the vacuum cavity in horizontal and vertical directions, an electric cylinder and a transmission mechanism are mounted on each of the four bases, a jaws block and a position fixing plate are correspondingly provided on an inner wall of the vacuum cavity at each face. The transmission mechanism includes an oil-free sleeve, a moving connecting rod onto which the position fixing plate is fixed, a corrugated pipe, and an electric cylinder connecting block whose both ends are screwed with the moving connecting rod and the electric cylinder, the jaws block is fixedly connected with the position fixing plate. The disclosure utilizes the electric cylinder to drive the jaws block to complete specified linear displacement, and satisfies back-end beam quality requirements.

Abstract: An electrical pulse stimulation system includes a pulse generator, a first lead electrically connected to the pulse generator, and a second lead electrically connected to the pulse generator. The pulse generator is configured to deliver a left sacral nerve electrical pulse stimulation signal to the first lead and deliver a right sacral nerve electrical pulse stimulation signal to the second lead. The pulse generator is further configured to determine and adjust a stimulation quantity proportion of the left sacral nerve electrical pulse stimulation signal and the right sacral nerve electrical pulse stimulation signal according to a sacral nerve data of a patient.

Abstract: Disclosed is a beam energy dispersion adjusting mechanism for superconducting proton cyclotron. The adjusting mechanism includes a vacuum cavity, bases are symmetrically mounted on outer walls of four faces of the vacuum cavity in horizontal and vertical directions, an electric cylinder and a transmission mechanism are mounted on each of the four bases, a jaws block and a position fixing plate are correspondingly provided on an inner wall of the vacuum cavity at each face. The transmission mechanism includes an oil-free sleeve, a moving connecting rod onto which the position fixing plate is fixed, a corrugated pipe, and an electric cylinder connecting block whose both ends are screwed with the moving connecting rod and the electric cylinder, the jaws block is fixedly connected with the position fixing plate. The disclosure utilizes the electric cylinder to drive the jaws block to complete specified linear displacement, and satisfies back-end beam quality requirements.