Patents by Inventor Bob Dale Brown

Bob Dale Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphonic acid-based cationic lipids
    Patent number: 6172049
    Abstract: The present invention provides novel phosphonic acid-based cationic lipids of the general structure: or a salt, or solvate, or enantiomers thereof wherein; (a) R1 is a lipophilic moiety; (b) R2 is a positively charged moiety; (c) R3 is a lipophilic moiety of 1 to about 24 carbon atoms, a positively charged moiety, or a negatively charged moiety; (d) n is an integer from 0 to 8; (e) X− is an anion or polyanion; (f) Y is N or 0, and (g) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid. The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
    Type: Grant
    Filed: June 7, 1999
    Date of Patent: January 9, 2001
    Assignee: Promega Biosciences, Inc.
    Inventors: Brian Patrick Dwyer, Alexandre V. Lehedev, Bob Dale Brown, David Aaron Schwartz
  • Dimeric cationic lipids
    Patent number: 6034135
    Abstract: The present invention provides novel dimeric cationic lipids. The present invention further provides compositions of these lipids with anionic or polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: March 7, 2000
    Assignee: Promega Biosciences, Inc.
    Inventors: David Aaron Schwartz, Brian Patrick Dwyer, William J. Daily, Kumar Srinivasan, Bob Dale Brown
  • Synthetic oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages
    Patent number: 6028188
    Abstract: Oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages which hybridize to RNA target sequences and methods for their preparation are provided.
    Type: Grant
    Filed: November 21, 1994
    Date of Patent: February 22, 2000
    Assignee: Genta Incorporated
    Inventors: Lyle John Arnold, Jr., Richard Isais Hogrefe, Mark Alan Reynolds, Timothy Andrew Riley, David Aaron Schwartz, Morteza Monir Vaghefi, Bob Dale Brown
  • Amide-based cationic lipids
    Patent number: 6020526
    Abstract: The present invention provides novel amide-based cationic lipids of the general structure: ##STR1## or a salt, or solvate, or enantiomers thereof wherein; (a) Y is a direct link or an alkylene of 1 to about 20 carbon atoms; (b) R.sub.1 is H or a lipophilic moiety; (c) R.sub.2, R.sub.3, and R.sub.4 are positively charged moieties, or at least one but not all of R.sub.2, R.sub.3, or R.sub.4 is a positive moiety and the remaining are independently selected from H, an alkyl moiety of 1 to about 6 carbon atoms, or a heterocyclic moiety of about 5 to about 10 carbon atoms; (d) n and p are independently selected integers from 0 to 8, such that the sum of n and o is from 1 to 16; (e) X.sup.- is an anion or polyanion and (f) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid; provided that if Y is a direct link and the sum of n and p is 1 then one of either R.sub.3 or R.sub.4 must have an alkyl moiety of at least 10 carbon atoms.
    Type: Grant
    Filed: July 22, 1996
    Date of Patent: February 1, 2000
    Assignee: Genta, Incorporated
    Inventors: David Aaron Schwartz, William J. Daily, Brian Patrick Dwyer, Kumar Srinivasan, Bob Dale Brown
  • Phosphonic acid-based cationic lipids
    Patent number: 5958901
    Abstract: The present invention provides novel phosphonic acid-based cationic lipids of the general structure: ##STR1## or a salt, or solvate, or enantiomers thereof wherein; (a) R.sub.1 is a lipophilic moiety; (b) R.sub.2 is a positively charged moiety; (c) R.sub.3 is a lipophilic moiety of 1 to about 24 carbon atoms, a positively charged moiety, or a negatively charged moiety; (d) n is an integer from 0 to 8; (e) X.sup.- is an anion or polyanion; (f) Y is N or O, and (g) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid.The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
    Type: Grant
    Filed: June 5, 1996
    Date of Patent: September 28, 1999
    Assignee: Genta Incorporated
    Inventors: Brian Patrick Dwyer, Alexandre V. Lehedev, Bob Dale Brown, David Aaron Schwartz
  • Amide-based oligomeric cationic lipids
    Patent number: 5877220
    Abstract: The present invention provides amide-based oligomeric cationic lipids. The present invention further provides compositions of these amide-based cationic lipids with anionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: March 2, 1999
    Assignee: Genta, Incorporated
    Inventors: David Aaron Schwartz, Brian Patrick Dwyer, William J. Daily, Kumar Srinivasan, Bob Dale Brown