Patents by Inventor Bob G. Sanders
Bob G. Sanders has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8664264Abstract: The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.Type: GrantFiled: February 28, 2012Date of Patent: March 4, 2014Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Weiping Yu
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Publication number: 20120251616Abstract: The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.Type: ApplicationFiled: February 28, 2012Publication date: October 4, 2012Inventors: Bob G. Sanders, Kimberly Kline, Weiping Yu
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Patent number: 8148424Abstract: The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.Type: GrantFiled: April 30, 2010Date of Patent: April 3, 2012Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Weiping Yu
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Publication number: 20100303899Abstract: The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.Type: ApplicationFiled: April 30, 2010Publication date: December 2, 2010Inventors: BOB G. SANDERS, Kimberly Kline, Weiping Yu
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Publication number: 20100292316Abstract: The instant invention concerns chroman ring derivative compounds such as vitamin E derivatives and methods for their use. In certain aspects, methods for treating subjects comprising Arg, JNK, p73, NOXA or FOXO1 positive cancers are provided. In still further aspects, methods for treating cell proliferative disease such as cancer by administration of a chroman ring compound in conjunction with a P13 or Akt kinase inhibitor are described.Type: ApplicationFiled: July 9, 2008Publication date: November 18, 2010Applicant: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline
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Patent number: 7718814Abstract: The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R1 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.Type: GrantFiled: October 30, 2007Date of Patent: May 18, 2010Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Weiping Yu
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Patent number: 7608638Abstract: The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.Type: GrantFiled: October 22, 2007Date of Patent: October 27, 2009Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Daurence Hurley, Robb Gardner, Marla Menchaca, Weiping Yu, Puthucode N. Ramanan, Shenquan Liu, Karen Israel
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Publication number: 20080161349Abstract: The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R1 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.Type: ApplicationFiled: October 30, 2007Publication date: July 3, 2008Applicant: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Weiping Yu
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Publication number: 20080119514Abstract: The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.Type: ApplicationFiled: October 22, 2007Publication date: May 22, 2008Inventors: Bob G. Sanders, Kimberly Kline, Daurence Hurley, Robb Gardner, Marla Menchaca, Weiping Yu, Puthucode N. Ramanan, Shenquan Liu, Karen Israel
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Patent number: 7312232Abstract: The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound having said structural formula.Type: GrantFiled: August 20, 2003Date of Patent: December 25, 2007Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Laurence Hurley, Robb Gardner, Marla Menchaca, Weiping Yu, Puthucode N. Ramanan, Shenquan Liu, Karen Israel
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Patent number: 7300954Abstract: The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitrites; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.Type: GrantFiled: October 28, 2003Date of Patent: November 27, 2007Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Weiping Yu
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Patent number: 7045324Abstract: The present invention provides a novel tocopherol associated protein (TAP-38) DNA/protein with a 76 nucleotide base deletion resulting in a 25 amino acid deletion, followed by 90 novel nucleotides that code for 30 novel amino acids that are not expressed by TAP-46. The present invention provides data showing that TAP-38 enhances the apoptotic inducing properties of tocopherol based compounds, and blockage of TAP reduces the effectiveness of tocopherol based compounds. Thus, the present invention claim that expression of TAP-38 by tumor cells enhances the apoptotic inducing properties of tocopherol based compounds. The present invention provides aerosol liposome/transfection/infection methods for delivery of TAP-38 and TAP-46 cDNA plasmids separately and in combination with tocopherol based apoptotic inducing agents as well as with other chemotherapeutic agents as a method for treatment and prevention of cellular proliferative diseases and disorders.Type: GrantFiled: April 21, 2003Date of Patent: May 16, 2006Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Weiping Yu, Hui Liu, Feras Hantash
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Patent number: 7011835Abstract: The present invention is drawn to a safe, cost-effective, environmentally-friendly and ecologically-sound bioengineered pest eradication product and uses thereof. Immunological and genetic engineering techniques are used to generate monoclonal antibodies as well as viruses (phage) that display scFv heavy and/or light chain Ig fragments which exhibit high-avidity specific binding to cells of the microvilli of the midgut of imported fire ant queens. The specific monoclonal antibodies and phage displayed antibody Fab fragments are conjugated to a toxin for targeted delivery and destruction of imported fire ant queens, but not native species.Type: GrantFiled: February 10, 2000Date of Patent: March 14, 2006Assignee: Research Development FoundationInventors: Kimberly Kline, Bob G. Sanders
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Publication number: 20040235938Abstract: The present invention provides an antiproliferative compound having the structural formula 1Type: ApplicationFiled: August 20, 2003Publication date: November 25, 2004Applicant: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Laurence Hurley, Robb Gardner, Marla Menchaca, Weiping Yu, Puthucode N. Ramanan, Shenquan Liu, Karen Israel
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Publication number: 20040175813Abstract: Mutated p53 proteins comprising amino acids deletion were disclosed herein. The mutant p53 exhibits high cellular retention and is capable of rendering tumor cells sensitive to apoptotic inducing agents such as &ggr;-irradiation or chemotherapeutic agents. The mutant p53 protein can be delivered separately or in combination with apoptotic inducing agents via aerosol liposome/transfection/infection methods to treat cellular proliferative diseases and disorders in humans and animals.Type: ApplicationFiled: October 29, 2003Publication date: September 9, 2004Inventors: Kimberly Kline, Bob G. Sanders, Weiping Yu
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Publication number: 20040152883Abstract: The present invention discloses cloning of tocopherol associated protein TAP-38 and deletion mutants of TAP-46. TAP-38, which shares homology with the previously identified TAP-46, enhances the apoptotic inducing properties of tocopherol based compounds, and blockage of TAP-38 or TAP-46 reduces the effectiveness of tocopherol based compounds. Thus, delivery of TAP-38 and TAP-46 cDNA by aerosol liposome/transfection/infection methods, separately or in combination with tocopherol-based apoptosis-inducing agents as well as with other chemotherapeutic agents, would be useful for treatment and prevention of cellular proliferative diseases and disorders.Type: ApplicationFiled: October 29, 2003Publication date: August 5, 2004Inventors: Bob G. Sanders, Kimberly Kline, Weiping Yu, Hui Liu, Feras M. Hantash
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Patent number: 6770672Abstract: The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.Type: GrantFiled: February 11, 2000Date of Patent: August 3, 2004Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Laurence Hurley, Robb Gardner, Marla Menchaca, Weiping Yu, Puthucode N. Ramanan, Shenquan Liu, Karen Israel
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Publication number: 20040097431Abstract: The present invention provides an antiproliferative compound having a structural formula 1Type: ApplicationFiled: October 28, 2003Publication date: May 20, 2004Applicant: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Weiping Yu
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Patent number: 6703384Abstract: The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen o r sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.Type: GrantFiled: November 5, 2001Date of Patent: March 9, 2004Assignee: Research Development FoundationInventors: Bob G. Sanders, Kimberly Kline, Weiping Yu
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Publication number: 20040034198Abstract: A p53 cDNA with a 21 nucleotide base deletion that codes for a seven amino acid deleted p53 protein was disclosed herein. The mutant p53 exhibits high cellular retention and is capable of rendering tumor cells sensitive to apoptotic inducing agents such as &ggr;-irradiation or chemotherapeutic agents. The mutant p53 protein can be delivered separately or in combination with apoptotic inducing agents via aerosol liposome/transfection/infection methods to treat cellular proliferative diseases and disorders in humans and animals.Type: ApplicationFiled: May 23, 2003Publication date: February 19, 2004Inventors: Kimberly Kline, Bob G. Sanders, Weiping Yu