Patents by Inventor Bobak Mosadegh
Bobak Mosadegh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11918319Abstract: Systems and method to measure pressure are described herein. The system can include a force sensor can that be implanted into a patient to measure, for example, cardiac pressure. The force sensor can include first and second film layers that can define a plurality of pressure cells. An external pressure can deform the pressure cells and change their resonant frequency. When exposed to an acoustic signal, the pressure cells can resonant at a pressure-dependent resonant frequency. The system can detect reflected acoustic waves generated by the resonance of the pressure cells. The system can convert the frequency readings into pressure values.Type: GrantFiled: February 1, 2019Date of Patent: March 5, 2024Assignee: CORNELL UNIVERSITYInventors: Seyedhamidreza Alaie, Amir Ali Amiri Moghadam, Subhi Al'Aref, James K. Min, Bobak Mosadegh, Simon Dunham
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Publication number: 20230363832Abstract: Disclosed are approaches that may provide image-guidance to interventionalists by providing true 3D visualization and quantitative feedback in real-time. A guidance system may allow a physician to manipulate a medical device and see a 3D rendering with quantitative feedback floating in mixed reality, next to standard monitors. Image tracking may detect and co-register the medical device's 3D position using, for example, bi-plane C-arm X-ray fluoroscopy and provide a 3D trajectory as quantitative feedback. Patterns in a fluoroscopic image may be used to accurately determine an object's z-position from a single angle projection.Type: ApplicationFiled: September 22, 2021Publication date: November 16, 2023Applicant: Cornell UniversityInventors: Bobak Mosadegh, Matin Torabinia
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Publication number: 20230347571Abstract: Implanted medical devices need a mechanism of immobilization to surrounding tissues, which minimizes tissue damage while providing reliable long-term anchoring. This disclosure relates to techniques for patterning arbitrarily shaped 3D objects and to patterned balloon devices having micro- or nano-patterning on an outer surface of an inflatable balloon. The external pattern can provide enhanced friction and anchoring in an aqueous environment. Examples of these types of patterns are hexagonal arrays inspired by tree frogs, corrugated patterns, and microneedle patterns. The patterned balloon devices can be disposed between an implant and surrounding tissues to facilitate anchoring of the implant.Type: ApplicationFiled: April 3, 2023Publication date: November 2, 2023Applicant: Cornell UniversityInventors: Seyedhamidreza Alaie, Simon Dunham, Bobak Mosadegh, James K. Min, Amir Ali Amiri Moghadam
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Patent number: 11690633Abstract: The present disclosure describes a device that can be implanted into the left atrial appendage for occlusion. The device can prevent or reduce thrombus formation in this anatomic region for patients with atrial fibrillation. This device includes a patient-specific inflatable device that represents a patient's anatomy or morphological class. The inflatable device can be designed by imaging (e.g., computed tomography, magnetic resonance imaging) the patient's anatomy. Through a catheter (or surgically), the inflatable device can be filled with an inflation fluid to occlude the appendage in a patient-specific fashion.Type: GrantFiled: April 26, 2022Date of Patent: July 4, 2023Assignee: CORNELL UNIVERSITYInventors: James K. Min, Simon Dunham, Bobak Mosadegh, Sanlin S. Robinson
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Publication number: 20230146045Abstract: Methods for fabricating flexible/stretchable circuits can include identifying one or more regions of a printed circuit board (PCB) for selectively removing insulation material. The PCB can include one or more electrically conductive structures arranged on an insulation layer. The method can include applying, within each region of the one or more regions, thermal energy via a heat source to a surface of the PCB within the region such that insulation material of the insulation layer is removed from the region while a portion of the insulation layer beneath the one or more electrically conductive structures is maintained. The flexible/stretchable circuit can be laminated on a soft actuator to form a soft robotic device.Type: ApplicationFiled: April 23, 2021Publication date: May 11, 2023Applicant: Cornell UniversityInventors: Simon Dunham, Bobak Mosadegh, Varun Kashyap, Tejas Doshi, Alexandre Caprio
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Publication number: 20220387675Abstract: Systems, methods, and devices having improved conformal properties for biomedical signal measurement are disclosed. A device can have a first polymer substrate coupled to a conductive layer forming a conductive trace electrically coupled to a conductive pad exposed via an opening. The device can have a second polymer substrate forming a first cavity between the first polymer substrate and the second polymer substrate. The device can have a first inlet portion that receives a fluid that expands the first cavity causing the device to conform to an anatomical structure. The structure can be an atrium, such as the left atrium, of the heart of a patient. The device can conform to the walls of the tissue structure, and the conductive pad exposed via the opening can detect a signal from the wall of the tissue structure. The signal can be provided to an external measurement device for processing.Type: ApplicationFiled: November 6, 2020Publication date: December 8, 2022Applicant: CORNELL UNIVERSITYInventors: Nazanin Farokhnia, Alexandre Caprio, Varun Kashyap, Subhi Al' Aref, Bobak Mosadegh, James K. Min, Simon Dunham
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Publication number: 20220288353Abstract: A catheter system is provided that reduces the risk of catheter-associated urinary tract infections by preventing bacteria near the urethral opening from being carried by the catheter during insertion, and by allowing cycling (filling and emptying) of the bladder. The system includes a main lumen, and a balloon near a distal end thereof that is inflatable, after insertion, to open an eyelet to the main lumen that allows urine to flow from the bladder into the main lumen. A catheter system with two balloons, e.g., a retention and an actuation balloon, is also provided herein. An access port at a proximal end has a resting configuration that closes the proximal end of main lumen to prevent drainage of urine through the main lumen. An access cap is provided that, when installed in the access port, opens the access port to allow urine to flow therethrough.Type: ApplicationFiled: July 31, 2020Publication date: September 15, 2022Inventors: Jeremy B. Wiygul, Simon Dunham, Bobak Mosadegh
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Publication number: 20220249101Abstract: The present disclosure describes a device that can be implanted into the left atrial appendage for occlusion. The device can prevent or reduce thrombus formation in this anatomic region for patients with atrial fibrillation. This device includes a patient-specific inflatable device that represents a patient's anatomy or morphological class. The inflatable device can be designed by imaging (e.g., computed tomography, magnetic resonance imaging) the patient's anatomy. Through a catheter (or surgically), the inflatable device can be filled with an inflation fluid to occlude the appendage in a patient-specific fashion.Type: ApplicationFiled: April 26, 2022Publication date: August 11, 2022Applicant: CORNELL UNIVERSITYInventors: James K. MIN, Simon DUNHAM, Bobak MOSADEGH, Sanlin S. ROBINSON
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Publication number: 20210162099Abstract: The present disclosure describes a system and a method for producing patient-specific small diameter vascular grafts (SDVG) for coronary artery bypass graft (CABG) surgery. In some embodiments, the method for producing SDVGs includes non-invasive quantification of patient-specific coronary and vascular physiology by applying computational fluid dynamics (CFD), rapid prototyping, and in vitro techniques to medical images and coupling the quantified patient-specific coronary and vascular physiology from the CFD to computational fluid-structure interactions and SDVG structural factors to design a patient-specific SDVG.Type: ApplicationFiled: February 8, 2021Publication date: June 3, 2021Inventors: James K. Min, Bobak Mosadegh, Simon Dunham, Kranthi Kumar Kolli
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Publication number: 20210142886Abstract: The present disclosure describes a system that can enable the prediction of coronary flow without invasive medical procedure. The system can generate physical models that can provide an accurate assessment of coronary mechanics and enable realistic simulation of coronary procedures. The models can enable the hemodynamic measurement of flow through the model and the study of flow dynamics through the model and the biomechanics of the model.Type: ApplicationFiled: April 11, 2019Publication date: May 13, 2021Inventors: James K. Min, Simon Dunham, Bobak Mosadegh, Kranthi Kumar Kolli
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Publication number: 20210068951Abstract: The present disclosure describes a replacement valve that can remove or lacerate the anterior mitral leaflet (or other portion of the heart) to reduce the obstruction of the left ventricular outflow tract (LVOT). The replacement valve can include integrated cutting features to lacerate a leaflet of a heart valve. For example, the cutting features can include blades or electrosurgical features that can cut the leaflets to reduce obstruction of the LVOT. As the cutting features are integrated components of the replacement valve, the laceration of the leaflet can follow implantation of the replacement valve and enables for clinical decisions to be made based on the degree of obstruction to the LVOT following the implantation procedure.Type: ApplicationFiled: March 21, 2019Publication date: March 11, 2021Inventors: Simon Dunham, Bobak Mosadegh, James K. Min, Tracey Lustig
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Patent number: 10912865Abstract: The present disclosure describes a system and a method for producing patient-specific small diameter vascular grafts (SDVG) for coronary artery bypass graft (CABG) surgery. In some embodiments, the method for producing SDVGs includes non-invasive quantification of patient-specific coronary and vascular physiology by applying computational fluid dynamics (CFD), rapid prototyping, and in vitro techniques to medical images and coupling the quantified patient-specific coronary and vascular physiology from the CFD to computational fluid-structure interactions and SDVG structural factors to design a patient-specific SDVG.Type: GrantFiled: July 22, 2017Date of Patent: February 9, 2021Assignee: CORNELL UNIVERSITYInventors: James K. Min, Bobak Mosadegh, Simon Dunham, Kranthi Kumar Kolli
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Publication number: 20200405397Abstract: The systems and method described herein can generate guidance images that can indicate the real-time position of a medical device within an anatomical target. For example, the images can be high-resolution, 3D holographic renderings of a catheter (an example medical device) within a patient's heart (an example anatomical target). The guidance system can generate images that include computer generated (CG) images or models of the medical device and target anatomy. The guidance system can generate the CG images of the target anatomy from pre-operative images of a first modality, such as CT images or MR images. The guidance system can determine real-time placement position of the medical device from an intra-operative image of a second modality, such as fluoroscopic images.Type: ApplicationFiled: February 26, 2019Publication date: December 31, 2020Applicant: Cornell UniversityInventors: Jun Liu, Bobak Mosadegh, Gurpreet Singh, Simon Dunham, James K. Min, Subhi Al'Aref
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Publication number: 20200376740Abstract: Implanted medical devices need a mechanism of immobilization to surrounding tissues, which minimizes tissue damage while providing reliable long-term anchoring. This disclosure relates to techniques for patterning arbitrarily shaped 3D objects and to patterned balloon devices having micro- or nano-patterning on an outer surface of an inflatable balloon. The external pattern can provide enhanced friction and anchoring in an aqueous environment. Examples of these types of patterns are hexagonal arrays inspired by tree frogs, corrugated patterns, and microneedle patterns. The patterned balloon devices can be disposed between an implant and surrounding tissues to facilitate anchoring of the implant.Type: ApplicationFiled: October 3, 2018Publication date: December 3, 2020Inventors: Seyedhamidreza Alaie, Simon Dunham, Bobak Mosadegh, James K. Min, Amir Ali Amiri Moghadam
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Patent number: 10843336Abstract: Reconfigurable soft robotic actuators with hard components are described. Magnetic attraction is used to couple flexible molded bodies capable of actuation upon pressurization with other flexible molded bodies and/or with hard components (e.g., frames and connectors) to form a seal for fluidic communication and cooperative actuation. Pneumatic de-coupling chambers built into the hard components to de-couple the hard components from the magnetically-coupled soft molded bodies are described. The use of magnetic self-alignment coupling and pneumatic de-coupling allows for the remote assembly and disassembly of complex structures involving hard and soft components. The magnetic coupling allows for rapid, reversible reconfiguration of hybrid soft-hard robots for repair, testing new designs, and carrying out new tasks.Type: GrantFiled: May 8, 2018Date of Patent: November 24, 2020Assignee: President and Fellows of Harvard CollegeInventors: Sen Wai Kwok, Stephen A. Morin, Bobak Mosadegh, Ju-Hee So, Robert F. Shepherd, George M. Whitesides
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Publication number: 20200359897Abstract: Systems and method to measure pressure are described herein. The system can include a force sensor can that be implanted into a patient to measure, for example, cardiac pressure. The force sensor can include first and second film layers that can define a plurality of pressure cells. An external pressure can deform the pressure cells and change their resonant frequency. When exposed to an acoustic signal, the pressure cells can resonant at a pressure-dependent resonant frequency. The system can detect reflected acoustic waves generated by the resonance of the pressure cells. The system can convert the frequency readings into pressure values.Type: ApplicationFiled: February 1, 2019Publication date: November 19, 2020Inventors: Seyedhamidreza Alaie, Amir Ali Amiri Moghadam, Subhi Al'Aref, James K. Min, Bobak Mosadegh, Simon Dunham
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Publication number: 20200340974Abstract: A method of and system for detecting a gas or vapor includes providing a sensor comprising an electrode pair in electrical contact with a layer of porous material, the porous material layer having water adsorbed on its surface; contacting the sensor with a gas or vapor sample to be analysed; applying a voltage across the electrode pair of the sensor; and measuring a response, the response correlating to the presence of a target gas or vapor.Type: ApplicationFiled: July 10, 2020Publication date: October 29, 2020Inventors: Firat Güder, Bobak Mosadegh, Alar Ainla, George M. Whitesides
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Patent number: 10712337Abstract: A method of and system for detecting a gas or vapor includes providing a sensor comprising an electrode pair in electrical contact with a layer of porous material, the porous material layer having water adsorbed on its surface; contacting the sensor with a gas or vapor sample to be analysed; applying a voltage across the electrode pair of the sensor; and measuring a response, the response correlating to the presence of a target gas or vapor.Type: GrantFiled: October 22, 2015Date of Patent: July 14, 2020Assignee: President and Fellows of Harvard CollegeInventors: Firat Güder, Bobak Mosadegh, Alar Ainla, George M. Whitesides
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Patent number: 10704537Abstract: A soft robot device includes at least a first thermoplastic layer and a second thermoplastic layer, wherein at least one layer is comprised of an extensible thermoplastic material; at least one layer is an inextensible layer; and at least one layer comprises a pneumatic network, wherein the pneumatic network is configured to be in fluidic contact with a pressurizing source, wherein the first and second thermoplastic layers are thermally bonded to each other.Type: GrantFiled: May 29, 2018Date of Patent: July 7, 2020Assignee: President and Fellows of Harvard CollegeInventors: Jason Ming Ting, Alok Suryavamsee Tayi, Bobak Mosadegh, George M. Whitesides
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Patent number: 10689044Abstract: A pneumatically powered, fully untethered mobile soft robot is described. Composites consisting of silicone elastomer, polyaramid fabric, and hollow glass microspheres were used to fabricate a sufficiently large soft robot to carry the miniature air compressors, battery, valves, and controller needed for autonomous operation. Fabrication techniques were developed to mold a 0.65 meter long soft body with modified Pneumatic network actuators capable of operating at the elevated pressures (up to 138 kPa) required to actuate the legs of the robot and hold payloads of up to 8 kg. The soft robot is safe to handle, and its silicone body is innately resilient to a variety of adverse environmental conditions including snow, puddles of water, direct (albeit limited) exposure to flames, and the crushing force of being run over by an automobile.Type: GrantFiled: June 30, 2015Date of Patent: June 23, 2020Assignee: President and Fellows of Harvard CollegeInventors: Michael T. Tolley, Robert F. Shepherd, Bobak Mosadegh, Robert J. Wood, George M. Whitesides